Heart Failure in Women

Bozkurt, Biykem; Khalaf, Shaden

doi:10.14797/mdcj-13-4-216

Cited by 93 publications

(52 citation statements)

References 83 publications

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“…These patients have a twofold higher risk of cardiovascular events than those without HF [ 30 , 31 ]. It is estimated the incidence of HF reaches 46% in 2030, which influences approximately 8 million individuals [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

Circulating Levels of IL-13, TGF-β1, and Periostin as Potential Biomarker for Coronary Artery Disease with Acute Heart Failure

Qiu

Fengyi

Zhang

2021

Evidence-Based Complementary and Alternative Medicine

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Objective. Coronary artery disease (CAD) and associated comorbidities such as heart failure (HF) remain the leading cause of morbidity and mortality worldwide, attributed to, at least partially, the lack of biomarkers for efficient disease diagnosis. The study intended to explore potential biomarkers for predicting the presence of HF in CAD patients. Methods. According to the presence of HF, 83 CAD patients with HF were assigned to the AHF group and 52 CAD patients without HF to the CAD group. Additionally, healthy controls (n = 52) were those who had received physical examinations at the same period. The serum levels of IL-13, TGF-β1, and periostin were detected by the enzyme-linked immunosorbent assay (ELISA). Left ventricular ejection fraction (LVEF), left ventricular end-diastolic dimension (LVEDD), left ventricle-end diastolic volume (LVEDV), and left ventricular mass index (LVMI) were detected 3 times by color Doppler ultrasound. The predictive values of IL-13, TGF-β1, and periostin methods were compared by receiver-operating characteristic (ROC) analysis and the area under the curve (AUC). Results. Increased levels of IL-13, TGF-β1, and periostin were noted in the AHF group than in the control and CAD groups ( p < 0.001 ); the CAD group showed higher levels of IL-13, TGF-β1, and periostin than the control group ( p < 0.001 ). Based on the NYHA classification, there were 33 cases with grade II, 28 cases with grade III, and 22 cases with grade IV among 83 CAD patients with HF. It was found that the serum levels of IL-13, TGF-β1, and periostin were higher in the AHF-IV group than in the AHF-III and AHF-II groups ( p < 0.001 ); these levels were also higher in the AHF-III group than in the AHF-II group ( p < 0.001 ). The periostin level was positively correlated with the levels of IL-13 (r = 0.458) and TGF-β1 (r = 0.569) in CAD patients with AHF. Besides, the serum levels of periostin (r = -0.425), IL-13 (r = -0.341), and TGF-β1 (r = -0.435) were negatively correlated with the LVEF of CAD patients with AHF, respectively. When IL-13, TGF-β1, and periostin levels were used to predict the presence of AHF in CAD patients in combination, the sensitivity and specificity were 75.9% and 90.38%, respectively, with the AUC of 0.906 (95% CI: 0.912–0.996). Conclusion. These data reveal that IL-13, TGF-β1, and periostin levels might be associated with the occurrence of AHF in CAD patients and their combination shows the predictive value for the presence of AHF in CAD patients.

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Section: Discussionmentioning

confidence: 99%

Circulating Levels of IL-13, TGF-β1, and Periostin as Potential Biomarker for Coronary Artery Disease with Acute Heart Failure

Qiu

Fengyi

Zhang

2021

Evidence-Based Complementary and Alternative Medicine

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“…Consequently, heart failure concerns older women compared to men, potentially carrying higher disease severity risks and a much longer length of stay than men. This finding is aligned with previous epidemiological research, which stated that heart failure's occurrence increased with advancing age and affected older women greater than men [60].…”

Section: Discussionsupporting

confidence: 92%

Association Rules Mining for Hospital Readmission: A Case Study

et al. 2021

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As an indicator of healthcare quality and performance, hospital readmission incurs major costs for healthcare systems worldwide. Understanding the relationships between readmission factors, such as input features and readmission length, is challenging following intricate hospital readmission procedures. This study discovered the significant correlation between potential readmission factors (threshold of various settings for readmission length) and basic demographic variables. Association rule mining (ARM), particularly the Apriori algorithm, was utilised to extract the hidden input variable patterns and relationships among admitted patients by generating supervised learning rules. The mined rules were categorised into two outcomes to comprehend readmission data; (i) the rules associated with various readmission length and (ii) several expert-validated variables related to basic demographics (gender, race, and age group). The extracted rules proved useful to facilitate decision-making and resource preparation to minimise patient readmission.

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“…When presenting with end-stage HF, women are more likely to describe severe symptomatology, but their prognosis is as poor as in male patients. 4 Even though, the incidence of HF in female patients does not differ from the one in the male population, female patients remain strongly underrepresented in the HF clinical trials. 12 , 13 There is an ongoing debate concerning gender differences in surgical end-stage HF therapy.…”

Section: Discussionmentioning

confidence: 99%

“…However, randomized control trials investigating left ventricular device (LVAD) therapy present only 20% to 25% of subjects as women, with this underrepresentation being explained by the limited thoracic space in female patients not being able to sufficiently house the relatively large earlier generation LVAD’s. 2 – 5 Moreover, it has been described that the pathophysiology and subsequent epidemiology of HF in female patients differs to that of male patients. 6 – 9 Nevertheless, a lack of large gender-specific clinical trials analyzing the durable mechanical circulatory support (MCS) therapy exists.…”

Section: Introductionmentioning

confidence: 99%

Impact of gender in patients with continuous-flow left ventricular assist device therapy in end-stage heart failure

Szczechowicz¹,

Oßwald

Rad

et al. 2021

Int J Artif Organs

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Background: There is an ongoing debate about the influence of the female gender on postoperative outcomes after durable left ventricular assist device (LVAD) implantation. Despite the differences in pathophysiology of heart failure in females, therapy concepts are the same as in the male population. The aim of this study was to investigate the role of the female gender in surgical heart failure therapy. Materials and methods: Between August 2010 and January 2020, 207 patients were treated with durable LVAD at out institution. We matched 111 patients in two groups to compare the outcomes in male and female patients and to stratify the risk factors of mortality. Results: The groups were matched 2:1 and were comparable after matching. We found no difference in in-hospital and follow-up mortality between male and female patients. Postoperative adverse events and complications were found to be unvaried across male and female patients. Female patients had higher rates of postoperative LVAD-thrombosis compared to their male counterparts (13.5% vs 0, p = 0.001) and the rates of renal replacement therapy lasting over 90 days were also higher in the female group (33.8% vs 56.8%, p = 0.021). Furthermore, the female gender was not an independent predictor neither of in-hospital nor follow-up mortality. Conclusions: Durable continuous flow left ventricular assist devices as a bridge to transplantation or recovery in female patients are associated with a higher risk of acute kidney injury requiring RRT and are at a higher risk of LVAD-thrombosis. Nevertheless, survival rates between genders are similar.

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Heart Failure in Women

Cited by 93 publications

References 83 publications

Circulating Levels of IL-13, TGF-β1, and Periostin as Potential Biomarker for Coronary Artery Disease with Acute Heart Failure

Circulating Levels of IL-13, TGF-β1, and Periostin as Potential Biomarker for Coronary Artery Disease with Acute Heart Failure

Association Rules Mining for Hospital Readmission: A Case Study

Impact of gender in patients with continuous-flow left ventricular assist device therapy in end-stage heart failure

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