Heart failure in a semi-urban setting in Cameroon: clinical characteristics, etiologies, treatment and outcome

Nkoké, Clovis; Jingi, Ahmadou Musa; Aminde, Léopold Ndemnge; Teuwafeu, Denis; Nkouonlack, Cyrille; Noubiap, Jean Jacques; Dzudié, Anastase

doi:10.21037/jxym.2019.02.01

Cited by 6 publications

(13 citation statements)

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“…The mean LVEF was 48 ± 20.39% (95% CI: 44.89-50.75) which was higher than that reported in other previously conducted studies. 8,11,13,15,22 This might be due to the presence of a high percentage of patients with preserved LVEF (63.3%) in this study. Like the Ugandan study, 19 dyspnea on exertion (90.3%) was the most frequent clinical finding.…”

Section: Discussionmentioning

confidence: 77%

“…This finding was confirmed by other studies where ischemia, CRHD, and corpulmonale were the leading causes for AHF related hospital admission. 13,14,17,21 Despite the majority, 31.4% of patients were admitted with an unknown precipitating factor, CAP (48.2%) was the main precipitant factors among new-onset AHF patients, while non-compliance to the medication (42.6%) was the leading one among ADCHF patients. In line with a previous study conducted in Ethiopia, it was revealed that pneumonia (47.5%) and drug discontinuation (22.5%) were the top precipitating factors.…”

Section: Discussionmentioning

confidence: 99%

“…12 Despite the recent advances in therapy for HF, several scientific literatures described that majority of hospitalized acute heart failure (HAHF) patients experience a high inhospital mortality rate with an estimated range of 6.3-24.4%. [7][8][9][10][13][14][15][16][17][18][19] A prospective cohort study in Brazil reported that the in-hospital mortality of HF patients was 21.6%. 20 A retrospective observational study in Cameroon reported that intra-hospital mortality was 18.45%.…”

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confidence: 99%

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Clinical Characteristics and In-Hospital Outcome of Acute Heart Failure Patients Admitted to the Medical Ward of University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia

Tigabe¹,

Fentahun²,

Getawa³

et al. 2021

VHRM

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Background: Despite the growing burden of heart failure in developing countries, data describing the clinical characteristics and in-hospital outcomes of acute heart failures are limited. Therefore, this study aimed at describing the clinical characteristics and in-hospital outcomes of acute heart failure patients admitted to the medical ward of University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia. Methods: A prospective observational hospital-based cross-sectional study was conducted on 226 patients with acute heart failure at the University of Gondar Comprehensive Specialized Hospital from November 2019 to October 2020. Data were collected by using a pretested data abstraction format and analyzed with Statistical Package for Social Sciences version 21. Bivariable and multivariable binary logistic regression model were fitted to identify factors associated with in-hospital outcome and reported with 95% confidence interval (CI). P-value <0.05 was considered as statistically significant. Results: The mean (± standard deviation) age of the study participant was 51.17±19.03 years and 59.3% were females. Majority, 60.6% of patients were admitted with new onset heart failure. Dyspnea (88.05%) and peripheral edema (80.5%) were the most frequent clinical findings. The in-hospital mortality was 10.6% (95% CI: 7.1-14.7). Atrial fibrillation (AOR=9.46; 95% CI: 1.49-60.29), concurrent ischemic heart disease (AOR=8.23; 95% CI: 1.15-58.89), being admitted with reduced left ventricular ejection fraction (AOR=5.36; 95% CI: 2.81-35.52), presence of orthopnea (AOR=6.63; 95% CI: 2.94-46.76), and using intranasal oxygen therapy (AOR=9.41; 95% CI: 1.35-65.82) were significantly associated with in-hospital mortality in patients with acute heart failure. Conclusion:The in-hospital mortality of acute heart failure patients was relatively higher in the study area. Therefore, specific preventative and therapeutic strategies focusing on heart failure patients with reduced left ventricular ejection fraction, atrial fibrillation, ischemic heart disease, orthopnea, and intranasal oxygen therapy are required to reduce the mortality rate.

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Section: Discussionmentioning

confidence: 77%

Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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Clinical Characteristics and In-Hospital Outcome of Acute Heart Failure Patients Admitted to the Medical Ward of University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia

Tigabe¹,

Fentahun²,

Getawa³

et al. 2021

VHRM

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“…A recent nationwide survey in the Cameroonian adult population reported a prevalence of hypertension of 29.2% [25]. Hypertension was the single most common etiological risk factor reported in studies on heart failure and stroke in Cameroon [14, 26]. This high prevalence of hypertension is associated with low awareness and poor control [25, 27].…”

Section: Discussionmentioning

confidence: 99%

Epidemiology of cardiovascular diseases related admissions in a referral hospital in the South West region of Cameroon: A cross-sectional study in sub-Saharan Africa

et al. 2019

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BackgroundSub-Saharan Africa (SSA) is experiencing an epidemic of cardiovascular diseases (CVD) as a result of a rapid epidemiological transition. Little is known about the admission for CVD and outcome in rural and semi-urban settings in Cameroon in this era of epidemiological transition. The aim of this study was to determine the frequency and the pattern of CVD admissions in the South West region of Cameroon.MethodsThis retrospective descriptive study included all adult patients admitted for CVD in the medical unit of the Buea Regional Hospital between Jan 2016 and December 2017.ResultsOut of the 3140 patients admitted, 499(15.9%) had CVD. There were 304(60.9%) females. The mean age was 58.7±16.2 years. There was no age difference between men and women (59.7 years vs 58.1years, p = 0.29). The most commonly affected age group was those aged 50–59 years (22%). Heart failure (38.5%), stroke (33.3%) and uncontrolled hypertension (22.4%) were the most prevalent CVDs. The length of hospital stay ranged from 1 to 37 days with a median length of hospital stay of 7 days. In-hospital case fatality was 78(15.8%). Mortality was higher in women compared to men (9% vs 7%, p = 0.43). The case fatality for stroke was higher compared to case fatality for heart failure (21.7% vs 16.7%, p = 0.23).ConclusionCVDs are a common cause of hospital admission in this semi-urban setting, dominated by heart failure. Women were disproportionately affected and it was associated with high mortality. Prevention, early detection and management of risk factors for cardiovascular disease are imperative given the growing burden of CVD in SSA to reduce CVD morbidity and mortality.

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“…The etiology of heart failure is hypertensive heart disease (47.7%), and to treat this, discharged patients receive loop diuretics (97.9%), ACEI (70.9%), betablockers (36.9%), and aldosterone antagonist (50.6%) [9]. Thiazide diuretics are reported to exhibit better effectiveness than ACEI in cases of acute myocardial infarction (HR=0.84; 95% CI 0.75-0.95), hospitalization due to heart failure (0.83; 0.74-0.95), and stroke (0.83; 0.74-0.95) [10].…”

Section: Introductionmentioning

confidence: 99%

Cost-Effectiveness Analysis of Antihypertensive Drug Use in Hypertension-Diabetes Mellitus and Hypertension-Heart Failure Inpatients at a Government Hospital in Yogyakarta, Indonesia

Baroroh¹,

Sari²,

Laili³

et al. 2021

Proceedings of the First International Conference on Health, Social Sciences and Technology (ICoHSST 2020)

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Hypertension and diabetes mellitus are the leading risk factors for cardiovascular diseases, which are increasing rapidly throughout the world. Hypertension is a non-communicable disease that remains a health problem in Indonesia, with a prevalence of up to 34.11% in 2018. This research was intended to identify cost-effective antihypertensive medication for inpatients with hypertension-diabetes mellitus and hypertensionheart failure. The research method used a retrospective cohort design and measured blood pressure (BP) 72 hours after treatment as the outcome of the observation. Based on a payer perspective, the medical expense was calculated from direct medical costs written in billing invoices. The research subjects were inpatients with hypertension-diabetes mellitus and hypertension-heart failure at a government hospital in Yogyakarta, Indonesia. In the cost-effectiveness analysis, Incremental Cost-Effectiveness Ratio (ICER) was calculated by dividing the difference in cost by the difference in the outcome of hypertension treatment.In the antihypertensive medication of hypertension-diabetes mellitus inpatients, angiotensin-receptor blockers/ calciumchannel blockers (ACB-CCB) were found to be more cost-effective than CCB with incremental costs of IDR 191,405/488,864 for every mmHg decrease of systolic/diastolic BP. Meanwhile, in the antihypertensive treatment of hypertension-heart failure inpatients, the combination of angiotensin-converting-enzyme inhibitors (ACEI) and diuretics was more cost-effective than ACEI-CCB (ICERs= IDR 8,303,483/-39,856,718 per mmHg) and ARB (ICERs= IDR 3,627,694/-2,380,075 per mmHg).In conclusion, ARB-CCB is a cost-effective medication for hypertension-diabetes mellitus inpatients, while ACEI-Diuretics offers a cost-effective hypertensive treatment for hypertension-heart failure inpatients.

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Heart failure in a semi-urban setting in Cameroon: clinical characteristics, etiologies, treatment and outcome

Cited by 6 publications

References 0 publications

Clinical Characteristics and In-Hospital Outcome of Acute Heart Failure Patients Admitted to the Medical Ward of University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia

Clinical Characteristics and In-Hospital Outcome of Acute Heart Failure Patients Admitted to the Medical Ward of University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia

Epidemiology of cardiovascular diseases related admissions in a referral hospital in the South West region of Cameroon: A cross-sectional study in sub-Saharan Africa

Cost-Effectiveness Analysis of Antihypertensive Drug Use in Hypertension-Diabetes Mellitus and Hypertension-Heart Failure Inpatients at a Government Hospital in Yogyakarta, Indonesia

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