Heart Failure and Diabetes Mellitus: Defining the Problem and Exploring the Interrelationship

Zadourian, Adena; Taub, Pam R.

doi:10.1016/j.amjcard.2019.10.024

Cited by 30 publications

(12 citation statements)

References 69 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The most common comorbid conditions were hypertension, dyslipidemia, obesity, ischemic heart disease, chronic renal failure, anemia, and obstructive sleep apnea. All these risk factors and associated pathologies were more prevalent in diabetic patients, have been described by other authors, and are associated with the natural evolution of diabetes [2,6,7].…”

Section: Discussionsupporting

confidence: 61%

“…These are two entities with an increase in worldwide prevalence and chronic phenotype. It has been described that approximately 6% of newly diagnosed diabetic patients will develop heart failure during their life [7]. Diabetic patients may develop a so-called diabetic cardiomyopathy [8], and there is also evidence regarding abnormal left ventricular remodeling in these patients after the occurrence of acute myocardial infarction [9].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Clinical Characteristics, Management, and In-Hospital Mortality in Patients with Heart Failure with Reduced Ejection Fraction According to Sex and the Presence of Type 2 Diabetes Mellitus

Méndez‐Bailón

Lorenzo-Villalba

Jiménez‐García

et al. 2022

JCM

View full text Add to dashboard Cite

Background: Type 2 diabetes mellitus (T2DM) is a risk factor for the development of heart failure with reduced ejection fraction (HFrEF). Aims: (1) To describe and compare the clinical characteristics and the use of diagnostic and therapeutic procedures among subjects hospitalized with HFrEF according to the presence of type 2 diabetes mellitus (T2DM) and sex; (2) to assess the effect of T2DM and sex on hospital outcomes among the patients hospitalized with HFrEF using propensity score matching (PSM); and (3) to identify which clinical variables were associated to in-hospital mortality (IHM) among the patients hospitalized with HFrEF and T2DM according to their sex. Methods: A retrospective cohort study from 2016 to 2019 using the Spanish National Hospital Discharge Database was conducted. The diagnosis and procedures were codified with the International Classification of Disease 10th version (ICD10). Subjects aged ≥ 40 with a primary diagnosis of HFrEF were included. We included those patients with a diagnosis of T2DM in any diagnosis position. The descriptive statistics used were total and relative frequencies (percentages), means with standard deviations, and medians with an interquartile range. To control the effect of confounding variables when T2DM patients and non-T2DM patients were compared, we matched the cohorts using PSM. Multivariable logistic regression models were used to identify which study variables independently affected the IHM among men and women with HF and T2DM. Also, this multivariable method was applied for sensitivity analyses to confirm the results of the PSM. Results: A total of 28,894 patients were included. T2DM was present in 39.59%. Women with T2DM more frequently had atrial fibrillation, valvular heart disease, anemia, dementia, depression, and hyponatremia than men with T2DM. However, men had more coronary heart disease, chronic renal disease, COPD, and obstructive sleep apnea. All the procedures were significantly more commonly used among men than women. Blood transfusion was the only procedure more frequently identified among women with T2DM. For the sensitivity analysis in patients with T2DM hospitalized with HFrEF, we confirmed the results of the PSM, finding that women had a 14% higher risk of dying in the hospital than men (OR 1.14; 95% CI 1.01–1.35). Obesity seemed to have a protective effect (OR 0.85; 95% CI 0.73–0.98) on the in-hospital morality. Conclusions: Subjects with diabetes are admitted for HFrEF and have a greater number of comorbidities than non-diabetics. Diabetic women have a higher mortality rate than men with diabetes and all the procedures evaluated were significantly more often used among men than women.

show abstract

Section: Discussionsupporting

confidence: 61%

Section: Introductionmentioning

confidence: 99%

Clinical Characteristics, Management, and In-Hospital Mortality in Patients with Heart Failure with Reduced Ejection Fraction According to Sex and the Presence of Type 2 Diabetes Mellitus

Méndez‐Bailón

Lorenzo-Villalba

Jiménez‐García

et al. 2022

JCM

View full text Add to dashboard Cite

show abstract

“…In the general population, diabetes and hypertension have been associated with the risk of both HFrEF and HFpEF and have been linked to pathophysiologic changes associated with HFrEF and HFpEF. 8 , 39 , 40 The lack of statistically significant findings with respect to HFrEF likely is due to the relative rarity of HFrEF after BC in this cohort.…”

Section: Discussionmentioning

confidence: 86%

Lifestyle and Cardiovascular Risk Factors Associated With Heart Failure Subtypes in Postmenopausal Breast Cancer Survivors

Reding

Cheng

Vasbinder

et al. 2022

JACC: CardioOncology

View full text Add to dashboard Cite

“…The mechanisms following the diminished systolic and diastolic functions of the heart also increase the risk of having heart failures in diabetic patients [60,61]. The chances of heart failure in a diabetic are very much that is 16-31% as compared to the general population that accounts for only 4-6% [62].…”

Section: Cardiomyopathymentioning

confidence: 99%

Diabetes and cardiovascular disease: inter-relation of risk factors and treatment

et al. 2020

View full text Add to dashboard Cite

Background The diabetes mellitus prevalence is still advancing and increasingly becoming one of the globally most severe and expensive chronic illnesses. The strong correlation between diabetes as well as the most prominent reason for diabetes and death in diabetic patients is cardiovascular disorders. Health conditions like dyslipidemia, hypertension, obesity, and other factors of risk like the risk of cardiovascular are frequent in diabetic persons and raise the likelihood of heart attacks. Main text In particular, several researchers have found diabetes mellitus-related biochemical pathways that raise the likelihood of cardiovascular disorder in people with diabetes individually. This review describes diabetes-cardiovascular disorder relationships, explores potential therapeutic mechanisms, addresses existing treatment, care, and describes the directions for the future for study. Conclusion Thus, in individuals with diabetes, it is important to concentrate on cardiovascular threat variables to reduce the illness’s lasting cardiovascular complications. Further work to enhance knowledge of the disease state and its impact on cardiovascular function is required to boost medical treatment and cardiovascular disorders result in people with diabetes.

show abstract

Heart Failure and Diabetes Mellitus: Defining the Problem and Exploring the Interrelationship

Cited by 30 publications

References 69 publications

Clinical Characteristics, Management, and In-Hospital Mortality in Patients with Heart Failure with Reduced Ejection Fraction According to Sex and the Presence of Type 2 Diabetes Mellitus

Clinical Characteristics, Management, and In-Hospital Mortality in Patients with Heart Failure with Reduced Ejection Fraction According to Sex and the Presence of Type 2 Diabetes Mellitus

Lifestyle and Cardiovascular Risk Factors Associated With Heart Failure Subtypes in Postmenopausal Breast Cancer Survivors

Diabetes and cardiovascular disease: inter-relation of risk factors and treatment

Contact Info

Product

Resources

About