Hearing Sensitivity in Older Adults: Associations with Cardiovascular Risk Factors in the Health, Aging and Body Composition Study

Helzner, Elizabeth; Patel, Ami; Pratt, Sheila; Sutton-Tyrrell, Kim; Cauley, Jane A.; Talbott, Evelyn O.; Kenyon, E.; Harris, Tamara B.; Satterfield, Suzanne; Ding, Jingzhong; Newman, Anne B.

doi:10.1111/j.1532-5415.2011.03444.x

Cited by 114 publications

(115 citation statements)

References 41 publications

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“…Inconsistent vascular findings may be due to evidence that associations between metrics of vascular health and hearing appear to be most consistent for low frequency hearing thresholds (Gates et al 1993;Pirodda et al 1999;Rosenhall and Sundh 2006;Helzner et al 2011). These low frequency findings are supported by evidence for pronounced capillary atrophy at the apex of the cochlea compared to the base (Mom et al 2005).…”

Section: Introductionsupporting

confidence: 60%

White Matter Hyperintensities Predict Low Frequency Hearing in Older Adults

Eckert

Kuchinsky

Vaden

et al. 2013

JARO

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Vascular disease has been proposed as a contributing factor for presbyacusis (age-related hearing loss). While this hypothesis is supported by pathological evidence of vascular decline in post-mortem human and animal studies, evidence in human subjects has been mixed with associations typically reported between a measure of vascular health and low frequency hearing in older women. Given the difficulty of characterizing the in vivo health of the cochlear artery in humans, an estimate of cerebral small vessel disease was used to test the prediction that age-related change in low frequency hearing and not high frequency hearing is related to a global decline in vascular health. We examined the extent to which these associations were specific to women and influenced by a history of high blood pressure in 72 older adults (mean age 67.12 years, SD08.79). Probability estimates of periventricular white matter hyperintensities (WMH) from T1-and fluid attenuated T2-weighted magnetic resonance images were significantly associated with a low frequency hearing metric across the sample, which were independent of age, but driven by women and people with a history of high blood pressure. These results support the premise that vascular declines are one mechanism underlying age-related changes in low frequency hearing.

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Section: Introductionsupporting

confidence: 60%

White Matter Hyperintensities Predict Low Frequency Hearing in Older Adults

Eckert

Kuchinsky

Vaden

et al. 2013

JARO

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“…If primary auditory and somatosensory cortices are part of a functional network (van de Ven et al 2009), then perhaps anatomical changes in one region could impact another region in the network (Oh et al 2011). In addition, extratemporal and temporal lobe findings may reflect comorbid factors such as vascular disease that have widespread aging effects on the peripheral auditory system (Gates et al 1993;Thomopoulos et al 1997;Torre et al 2005;Liew et al 2007;Helzner et al 2011;although see Parving et al 1993;Karamitsos et al 1996) and the brain (Eckert 2011). Influences of vessel disease on hearing in females (Gates et al 1993;Helzner et al 2011) could also explain the association between gray matter in the left Te1.2 region and low frequency hearing loss.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, extratemporal and temporal lobe findings may reflect comorbid factors such as vascular disease that have widespread aging effects on the peripheral auditory system (Gates et al 1993;Thomopoulos et al 1997;Torre et al 2005;Liew et al 2007;Helzner et al 2011;although see Parving et al 1993;Karamitsos et al 1996) and the brain (Eckert 2011). Influences of vessel disease on hearing in females (Gates et al 1993;Helzner et al 2011) could also explain the association between gray matter in the left Te1.2 region and low frequency hearing loss. Regardless of direct or indirect hearing loss effects on cortical morphology, extratemporal and temporal changes that occur with age are likely to further limit the efficacy of hearing loss interventions focused solely on improving audibility.…”

Section: Discussionmentioning

confidence: 99%

Auditory Cortex Signs of Age-Related Hearing Loss

Eckert

Cute

Vaden

et al. 2012

JARO

181

152

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Age-related hearing loss, or presbyacusis, is a major public health problem that causes communication difficulties and is associated with diminished quality of life. Limited satisfaction with hearing aids, particularly in noisy listening conditions, suggests that central nervous system declines occur with presbyacusis and may limit the efficacy of interventions focused solely on improving audibility. This study of 49 older adults (M069.58, SD08.22 years; 29 female) was designed to examine the extent to which low and/or high frequency hearing loss was related to auditory cortex morphology. Low and high frequency hearing constructs were obtained from a factor analysis of audiograms from these older adults and 1,704 audiograms from an independent sample of older adults. Significant region of interest and voxel-wise gray matter volume associations were observed for the high frequency hearing construct. These effects occurred most robustly in a primary auditory cortex region (Te1.0) where there was also elevated cerebrospinal fluid with high frequency hearing loss, suggesting that auditory cortex atrophies with high frequency hearing loss. These results indicate that Te1.0 is particularly affected by high frequency hearing loss and may be a target for evaluating the efficacy of interventions for hearing loss.

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“…59,63,64 In addition, in a related topic not without controversy, there are mixed results regarding the impact of cardiovascular disease on hearing loss. [65][66][67][68][69] Since ASA is recommended for cardiovascular prophylaxis, 70,71 if there is a true association between cardiovascular disease and hearing loss, then ASA might be indirectly protective of hearing in some patients through preventive effects.…”

Section: Potential Protective Effects Of Asa On Hearingmentioning

confidence: 99%

Ubiquitous Aspirin: A Systematic Review of Its Impact on Sensorineural Hearing Loss

Kyle¹,

Wang²,

Shin³

2014

Otolaryngol.--head neck surg.

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Objective-This systematic review evaluates the impact of aspirin on audiometric outcomes with respect to: (1) doses exceeding 325 mg daily, (2) doses of 325 mg daily or less, (3) studies applicable to the general populace, and (4) studies applicable to those with inflammatory conditions. It also assesses the impact of aspirin on (a) self-reported hearing loss, (b) noiseinduced audiometric changes, and (c) the adverse otological effects of aminoglycoside therapy.Data Sources-Computerized searches of MEDLINE, PubMed, Cochrane, and EMBASE databases were performed, updated through January 2014, and supplemented by manual searches and inquiries to topic experts.Review Methods-A systematic review was performed according to an a priori protocol. Data extraction was performed by 2 independent parties and focused on relevant audiological measurements, potential confounders, and study design elements associated with risk of bias, including utilization of randomization, prospective/retrospective data collection, and incorporation of blinding. Results-The Author ContributionsMeghann Elizabeth Kyle, acquisition of data, analysis and interpretation of data, drafting and editing manuscript, final approval; James C. Wang, acquisition of data, analysis and interpretation of data, contributing to manuscript, final approval; Jennifer J. Shin, analysis and interpretation of data, acquisition of data, drafting and editing manuscript, final approval. DisclosuresCompeting interests: Jennifer J. Shin receives royalties from book publications: Evidence-based Otolaryngology (Springer International, 2008, Otolaryngology Prep and Practice (Plural Publishing, 2013). Sponsorships: None. Funding source: None. Supplemental MaterialAdditional supporting information may be found at http://otojournal.org/supplemental. Author Manuscript shift); the effect was dose dependent and reversible in the short term. There were no audiometric data that confirm that long-term doses of 81 mg or 325 mg daily have no hearing consequences. Paradoxically, aspirin (in doses shown to be detrimental in isolation) had a protective effect when co-administered with intravenous gentamicin. HHS Public AccessConclusions-With the large-scale population utilization of aspirin for cardiovascular prophylaxis, the potential risks to hearing health should be considered for future longitudinal study, particularly given that short-term effects may be reversible.

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Hearing Sensitivity in Older Adults: Associations with Cardiovascular Risk Factors in the Health, Aging and Body Composition Study

Cited by 114 publications

References 41 publications

White Matter Hyperintensities Predict Low Frequency Hearing in Older Adults

White Matter Hyperintensities Predict Low Frequency Hearing in Older Adults

Auditory Cortex Signs of Age-Related Hearing Loss

Ubiquitous Aspirin: A Systematic Review of Its Impact on Sensorineural Hearing Loss

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