Hearing outcomes in children with Congenital Cytomegalovirus: A multi-center, single-enterprise experience

Tapasak, Brandon; Cronkite, Alex; Mai, Alexandra; Morlet, Thierry; Parkes, W.; Maul, Timothy M.; Pritchett, Cedric V.

doi:10.1016/j.ijporl.2022.111376

Cited by 3 publications

(3 citation statements)

References 38 publications

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“…Worldwide literature reports cases of stabilization of local retinal conditions or resolution of choroidal and retinal inflammation after antiviral treatment with gancyclovir or valgancyclovir in infants with cCMV [ 31 , 117 , 118 , 119 , 120 , 121 , 122 , 123 , 124 ]. However, authors of available studies on cCMV treatment often focus on complications other than ophthalmologic ones, primarily hearing disorders and the effectiveness of antiviral treatment in treating them [ 125 , 126 , 127 , 128 , 129 , 130 , 131 ]. Consequently, further studies involving a larger number of patients and employing detailed, targeted ophthalmologic diagnostics are necessary to determine the efficacy of antiviral therapy in the treatment of cCMV.…”

Section: Discussionmentioning

confidence: 99%

Ophthalmic Complications, Diagnosis, and Treatment of Congenital Human Cytomegalovirus Infection

Modrzejewska,

Połubiński,

Zdanowska

2024

JCM

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Background: Human cytomegalovirus (hCMV) is the most common etiological agent of congenital infections seen in newborns. Among the most commonly observed complications in children with congenital human cytomegalovirus infection are those affecting the visual system. Ocular complications of congenital CMV (cCMV) are a topic rarely addressed in the literature, which prompted the authors to update the available knowledge with the latest data. Methodology: English-language literature published between April 2000 and November 2023 (PubMed, NIH, Google Scholar) was analyzed for ocular complications of cCMV. The data obtained were categorized according to the ocular area involved and the incidence. A compilation of criteria for the symptomatic form of cCMV was also created. Results: The cCMV complications described in the literature affect all parts of the visual system: the anterior segment, the posterior segment, the posterior visual pathways, and the visual cortex. The most commonly described ocular complication of cCMV is choroidal and retinal scarring. Conclusions: Ophthalmic complications of cCMV can cause severe visual disturbances. Ophthalmic diagnosis in newborns should include hCMV PCR testing, which has the highest sensitivity and specificity. In the symptomatic form of cCMV, treatment should be instituted according to recommendations. A consensus should be established for screening of primary hCMV infection in pregnant women, the way in which to define the symptomatic form of cCMV, and the appropriateness and standards of treatment for primary hCMV infection in pregnant women.

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Section: Discussionmentioning

confidence: 99%

Ophthalmic Complications, Diagnosis, and Treatment of Congenital Human Cytomegalovirus Infection

Modrzejewska,

Połubiński,

Zdanowska

2024

JCM

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“…The recent neonatal guidelines recommending cCMV infection screening at birth contributed to observing shifts in the prevalence of cCMV; both centers have reached a stabilization in the annual number of cases. It is necessary to underline that in the absence of targeted or universal cCMV screening, most children are identified due to symptoms suggestive of cCMV infection [24]; in this regard, a recent position statement on the early-identification of hearing loss in cCMV infection through the NHS program has been published [25]. In recent years, the importance of newborn hearing screening in diagnosing congenital hearing loss has been demonstrated.…”

Section: Discussionmentioning

confidence: 99%

“…Currently, as there is no virological marker to predict who will develop sequelae [6], a better understanding of the natural history of the virus would be determinant in order to identify children at higher risk of developing hearing loss and to program tailored follow-up [38] through specific indicators [24]. Research has shown that the virus evolves on much shorter timescales and within individual infected subjects [39].…”

Section: Discussionmentioning

confidence: 99%

The Audiological Follow-Up of Children with Symptomatic Congenital Cytomegalovirus Infection: An Experience in Two Italian Centers

et al. 2023

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Background: Congenital cytomegalovirus (cCMV) infection is the leading cause of non-hereditary sensorineural hearing loss in children. While about 10% of children reportedly display symptoms at birth, 85–90% of cCMV infection cases are asymptomatic. However, 10–15% of these asymptomatic infants may later develop hearing, visual, or neurodevelopmental impairments. This study aimed to evaluate the impact of cCMV infection on newborns’ hearing function with a particular emphasis on progressive and late-onset cases. Methods: This study is a retrospective chart analysis with longitudinal character and was conducted in two Italian centers: Center 1 (from 1 November 2007 to 31 December 2021) and Center 2 (from 1 January 2012 to 31 December 2021). Data collected included newborn hearing screening results, characterization of hearing loss (unilateral/bilateral, degree of impairment), and audiological follow-up. Results: The cohort consisted of 103 children (42% males, 58% females). In total, 28 children presented with hearing impairment; 71.4% (20 out of 28) of the cases of hearing loss were severe/profound, with 35.7% of the cases due to unilateral hearing loss. Out of twenty-eight, six experienced progression of hearing loss and four had late-onset hearing loss. Conclusions: In the absence of universal cCMV screening, hearing screening at birth for cCMV remains a critical factor for early diagnosis. A significant percentage of children affected by cCMV with normal audiological evaluations at birth is easily lost to follow-up. Close collaboration between neonatologists, pediatricians, and audiological services is fundamental to ensure timely diagnosis and treatment of cCMV-related hearing loss.

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Late-onset, progressive sensorineural hearing loss in the paediatric population: a systematic review

Corazzi,

Fordington,

Brown

et al. 2024

Eur Arch Otorhinolaryngol

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Hearing outcomes in children with Congenital Cytomegalovirus: A multi-center, single-enterprise experience

Cited by 3 publications

References 38 publications

Ophthalmic Complications, Diagnosis, and Treatment of Congenital Human Cytomegalovirus Infection

Ophthalmic Complications, Diagnosis, and Treatment of Congenital Human Cytomegalovirus Infection

The Audiological Follow-Up of Children with Symptomatic Congenital Cytomegalovirus Infection: An Experience in Two Italian Centers

Late-onset, progressive sensorineural hearing loss in the paediatric population: a systematic review

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