Late-onset, progressive sensorineural hearing loss in the paediatric population: a systematic review

Corazzi, Virginia; Fordington, Surina; Brown, Tamsin Holland; Donnelly, Neil; Bewick, Jessica; Ehsani, Diana; Pelucchi, Stefano; Bianchini, Chiara; Ciorba, Andrea; Borsetto, Daniele

doi:10.1007/s00405-024-08527-x

Eur Arch Otorhinolaryngol

2024

DOI: 10.1007/s00405-024-08527-x

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Late-onset, progressive sensorineural hearing loss in the paediatric population: a systematic review

Virginia Corazzi,

Surina Fordington,

Tamsin Holland Brown

et al.

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2024

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Cited by 2 publications

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Bioinformatics Approach Unravels Potential Crosstalk Between Cytomegalovirus and Epilepsy

Rashdi,

Al-Mahrami

2024

Preprint

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Background Cytomegalovirus is a double-stranded DNA virus that is known to be associated with congenital disorders. Epilepsy is a neurological disorder that happens due to the activation of the inception of neurotransmitters. It is suggested that cytomegalovirus can affect epilepsy since it can reach the brain. This study aims to investigate the molecular crosstalk between epilepsy and Cytomegalovirus infection using a bioinformatics approach.Methods We used gene expression datasets related to each condition retrieved from the public database. Differentially expressed gene analysis has been done on each dataset group separately. The common genes that are significantly expressed in both conditions have been processed into protein-to-protein network analysis and gene enrichment analysis.Results Results showed that 192 common genes were identified across the two conditions. The three genes CCL2, CD44, and CCL3 have been defined as hub genes in protein-to-protein interaction networks with the highest centralities measures. This suggests the essential roles of these molecules in biological systems. Additionally, these genes are involved in inflammatory processing and immune response.Conclusion We suggest that inflammatory chemokine molecules have potential molecular crosstalk between Cytomegalovirus and Epilepsy. Therefore, more investigations are required to demonstrate the role of each suggested molecule in the association.

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Bioinformatics Approach Unravels Potential Crosstalk Between Cytomegalovirus and Epilepsy

Rashdi,

Al-Mahrami

2024

Preprint

View full text Add to dashboard Cite

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Bioinformatics Approach is Unraveling Potential Crosstalk between Cytomegalovirus and Epilepsy

Rashdi,

Al-Mahrami

2024

Preprint

View full text Add to dashboard Cite

Background: Cytomegalovirus (CMV) is a double-stranded DNA virus that is known to be associated with congenital disorders. Epilepsy is a neurological disorder that occurs due to the inception of neurotransmitters. It is suggested that cytomegalovirus can affect epilepsy since it can reach the brain. This study aimed to investigate the molecular crosstalk between epilepsy and Cytomegalovirus infection using a bioinformatics approach. Methods: We used gene expression datasets related to each condition retrieved from a public database. Differentially expressed gene analysis was performed for each dataset group separately. The common genes that were significantly expressed under both conditions were subjected to protein-to-protein network analysis and gene enrichment analysis. Results: A total of 192 common genes were identified across the two conditions. The three genes CCL2, CD44, and CCL3 were defined as hub genes in protein-to-protein interaction networks with the highest centrality. This finding suggested the essential roles of these molecules in biological systems. Additionally, these genes are involved in inflammatory processing and the immune response. Conclusion: We suggested that inflammatory chemokine molecules may participate in molecular crosstalk between CMV and epilepsy. Therefore, additionalinvestigations are required to demonstrate the role of each suggested molecule in this association.

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Late-onset, progressive sensorineural hearing loss in the paediatric population: a systematic review

Cited by 2 publications

References 55 publications

Bioinformatics Approach Unravels Potential Crosstalk Between Cytomegalovirus and Epilepsy

Bioinformatics Approach Unravels Potential Crosstalk Between Cytomegalovirus and Epilepsy

Bioinformatics Approach is Unraveling Potential Crosstalk between Cytomegalovirus and Epilepsy

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