Hearing loss in chronic myeloid leukemia

Abstract

A 12-year-old girl presented with abdominal pain, fever, and hearing impairment of 6 months duration. She had massive hepatosplenomegaly and anemia. On the basis of her peripheral blood and bone marrow findings, she was diagnosed as chronic myeloid leukemia (CML) in chronic phase. Her hearing was assessed by brainstem evoked responses (BERA), which showed objective improvement in hearing with hydroxyurea. The rare occurrence of deafness in CML is reviewed and possible pathogenesis is discussed.

Sudden sensorineural hearing loss as the first manifestation of chronic myeloid leukaemia: case report

“…This has been achieved in some hyperviscosity syndrome patients, suggesting that this type of deafness is reversible. 1,13 Unfortunately, we did not observe an improvement in our patient's hearing. In this case, hearing loss was probably caused by hyperleukocytosis with leukostasis and occlusion of the labyrinthine and other small arteries of the vertebrobasilar area.…”

“…It is clinically characterised by myeloid hyperplasia, leukocytosis with basophilia, and splenomegaly. 1 Common symptoms are bone pain, weight loss, excess sweating, fatigue, and early satiety and abdominal discomfort related to splenomegaly. Less common features relate to granulocyte or platelet dysfunction associated with infection, thrombosis or bleeding.…”

Chronic Myeloid Leukemia Presenting with Visual and Auditory Impairment in an Adolescent: An Insight to Management Strategies

“…Complications of HL due to CML such as leukostasis due to occlusion of small arterioles of vital organs are very rare during childhood. Our knowledge on treatment and outcome of organ dysfunction due to HL in CML is based on a few case reports unlike that of adults [3]. Neurological involvement including deafness, blindness and tinnitus was reported as 15.5% in a series of 33 adults with CML.…”

“…Headache, convulsions, stroke, papiledema, hearing loss, tinnitus and vertigo constitute the neurological aspect of clinical picture of CML [3,4].…”

Intratympanic steroid injection for sudden sensorineural hearing loss in a patient on hemodialysis

“…Thus, possibility of spontaneous recovery after an acute insult is resolved—cannot be ruled out . Elderly, children, diabetics, and those with sickle cell anemia, leukemia and other malignancies, and genetically predisposed—seem to be particularly vulnerable to SNHL …”