Sudden sensorineural hearing loss as the first manifestation of chronic myeloid leukaemia: case report

Diao, Mei; Fan, Tian; Sun, Jiayu

doi:10.1017/s0022215114002102

Cited by 8 publications

(11 citation statements)

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“…17–19 In our case, the patient had an extremely high WBC count of 780.72 × 10 9 /L and splenomegaly Schuffner 5. These data suggest that, among the multifactorial pathogenesis of CML, 5 , 6 , 8 , 10 , 17 , 22 the most notable in our case was hyperleukocytosis.…”

Section: Discussionsupporting

confidence: 53%

“…Some reported cases of SNHL in CML have shown hearing improvement after the patients received a combination of leukapheresis and chemotherapy. 8 , 18 , 22 , 23 This improvement indicates a reversible hearing loss and an association with hyperviscosity syndrome. 18 , 23 …”

Section: Discussionmentioning

confidence: 94%

“…Leukemia patients with otologics manifestations are seen in 15–40% of cases. 3 , 5 , 8 Unilateral or bilateral sensorineural hearing loss (SNHL), tinnitus, dizziness, and facial nerve paresis are among the symptoms. 3 , 18 Hearing loss has been linked to acute leukemias; however, it is uncommon in patients with CML, 3 , 5 , 6 , 17 , 18 , 20 especially in childhood; 15 it may develop later in the disease course than in acute leukemia.…”

Section: Introductionmentioning

confidence: 99%

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Sensorineural Hearing Loss in Juvenile CML: A Rare Case Report in Surabaya, Indonesia

Syamsuddin¹,

Notopuro²

2022

IMCRJ

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Chronic myeloid leukemia (CML) is a type of myeloproliferative neoplasm (MPN) in which granulocytes are the primary proliferating cells. CML in pediatric patients (juvenile CML) is an uncommon MPN, representing 2–3% of children newly diagnosed with leukemia. Sensorineural hearing loss that progresses rapidly is an uncommon early sign of a hematological disorder in patients with CML. This article presents the case of a 10-year-old patient with complaints of bilateral hearing loss for 2 weeks. Pure-tone audiometry indicated sensorineural hearing loss of the left ear and mixed hearing loss of the right ear. After an in-depth evaluation of a bone marrow smear and positivity for the BCR-ABL fusion gene, it was concluded that the patient had chronic-phase juvenile CML. However, hearing loss recovery after hydroxyurea therapy could not be observed because the patient died after suffering an uncontrolled seizure on day 14 of hospitalization.

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Section: Discussionsupporting

confidence: 53%

Section: Discussionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

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Sensorineural Hearing Loss in Juvenile CML: A Rare Case Report in Surabaya, Indonesia

Syamsuddin¹,

Notopuro²

2022

IMCRJ

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“…Spinal anestezi uygulamaları (dural ponksiyona bağlı intrakranial ve intrakoklear basıncın azalmakta ve düşük frekansları tutan işitme kaybına neden olabilmektedir) [10]. Hematolojik hastalıklar; hiperviskositeye sekonder ani işitme kaybı literatürde bildirilmiş olup özellikle kronik myelositer ve lenfoblastik lösemilerin başlangıç semptomu olduğu bildilmiştir [11,12]. Hastalarımızdan biri de 2 yıldır remisyonda olan kronik lenfositer lösemi hastasıydı ve tedavi sonrası işitmesi tamamen iyileşti.…”

Section: Discussionunclassified

Our results on sudden hearing loss and hyperbaric oxygen therapy role in recovery

Kılıç

2016

Ortadogu Tıp Derg

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ÖzAmaç: Bu çalışmada ani işitme kaybı tanısı konulan hastalara uyguladığımız tedaviler sonuçlarıyla sunulmuştur. Yöntem ve Gereçler:2014-2015 yılları arasında ani işitme kaybı tanısı konulan 19' u (%54) erkek, 16' sı (%46) kadın 35 hasta çalışmaya alındı. Tüm hastalara aynı medikal tedavi protokolu uygulandı. Beşinci gün sonunda işitmede düzelme olmayan hastalar hiperbarik oksijen tedavisine yönlendirildi. Sonuçta işitme kaybı, iyileşme dü-zeyine göre sınıflandırıldı. Bulgular:Hastaların yaşları 25-54 arasında, ortanca yaş 39,514 (± 8,139) idi. Tedavinin 1. gününde çekilen odiometride 7 hastanın (%20) eşiklerinde belirgin düzelme görüldü. Hiperbarik oksijen tedavisi (HBO2) alan 11 hastanın (%31) 10' unda (%91) orta düzeyde iyileşme, toplamda 17 hastada (%49) tam iyileşme, 6 hastada (%17) belirgin iyileşme, 10 hastada (%28) orta iyileşme düzeyi görüldü. 1 hastada (%2) ise iyileşme olmadı. Sonuçlar:Hastaların tamamına yakınında uygulanan tedavi protokolünden yarar sağladığı görülmüştür. Ayrıca prognozdaki yararı göz ardı edilmeksizin HBO2, tedavinin erken yada geç oduğuna bakılmaksızın streoide ek olarak kullanılmasını önermekteyiz. Anahtar kelimeler: hiperbarik oksijen, işitme kaybı, steroidOur results on sudden hearing loss and hyperbaric oxygen therapy role in recovery Abstract Aim: In this study, we describe the treatments applied to patients diagnosed with sudden hearing loss along with the observed treatment results. Materials and Methods:A total of 35 patients diagnosed with sudden hearing loss between 2014 and 2015, and consisting of 19 (54%) males and 16 (46%) females, were included into the study. The same medical treatment protocol was applied to all patients. Patients who failed to show any improvement by the end of the fifth day of treatment were subjected to hyperbaric oxygen treatment. Patients were classified according to the level of hearing loss recovery they exhibited. Results:The age of the patients ranged between 25 and 54, while the median age was 35.828. An Audiometric evaluation taken on the first day of treatment showed a significant improvement in the hearing threshold of 7 (20%) of the patients. Of the 11 patients who received hyperbaric oxygen treatment (HBO2), 10 (91%) exhibited moderate recovery. On the other hand, among the total of 35 patients included into the study, 17 (49%) showed full recovery, 6 (17%) showed significant recovery, and 10 (28%) showed moderate recovery. One (2%) of the patients did not exhibit any recovery. Conclusion:It was observed that nearly all of the patients benefited from the administered treatment protocol. In addition, considering its benefits on patient prognosis, we also recommend the use of steroid in addition HBO2 treatment, regardless of whether it is applied at an early or late stage of the treatment.

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“…Its pathophysiologic causes are multifactorial and include viral infections, autoimmune disorders, and vascular abnormalities [14][15][16]. Several previous studies described the incidence of SSNHL in vascular disorders such as leukemia, sickle-cell anemia, and iron-deficiency anemia [17][18][19]. However, most of these studies were based on case series.…”

Section: Introductionmentioning

confidence: 99%

Sudden Sensorineural Hearing Loss Associated with Nutritional Anemia: A Nested Case–Control Study Using a National Health Screening Cohort

Kim

Wee

Min

et al. 2020

IJERPH

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Previous studies have suggested an association of anemia with hearing loss. The aim of this study was to investigate the association of nutritional anemia with sudden sensorineural hearing loss (SSNHL), as previous studies in this aspect are lacking. We analyzed data from the Korean National Health Insurance Service-Health Screening Cohort 2002–2015. Patients with SSNHL (n = 9393) were paired with 37,572 age-, sex-, income-, and region of residence-matched controls. Both groups were assessed for a history of nutritional anemia. Conditional logistic regression analyses were performed to calculate the odds ratios (ORs) (95% confidence interval, CI) for a previous diagnosis of nutritional anemia and for the hemoglobin level in patients with SSNHL. Subgroup analyses were conducted for age and sex. Age, sex, income, and region of residence were stratified. Obesity, smoking, drinking alcohol, systolic/diastolic blood pressure, fasting blood glucose, total cholesterol, and the Charlson Comorbidity Index were considered in the regression models. Nutritional anemia was present in 4.8% (449/9393) of patients with SSNHL and 4.0% (1494/37,572) of controls (p < 0.001). The SSNHL group demonstrated 1.20-fold higher odds for nutritional anemia (95% CI = 1.08–1.34, p = 0.001). Hemoglobin levels were not associated with SSNHL. In subgroups <60 years old, there was a consistent positive association of nutritional anemia with SSNHL (adjusted OR = 1.55, 95% CI = 1.11–2.15, p = 0.010 for men <60 years old, and adjusted OR = 1.22, 95% CI = 1.02–1.45, p = 0.028 for women <60 years old). Nutritional anemia, but not hemoglobin level, was associated with an increased risk of SSNHL.

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Sudden sensorineural hearing loss as the first manifestation of chronic myeloid leukaemia: case report

Abstract: Every case of sudden sensorineural hearing loss must be carefully evaluated, and haematological disorders must be considered in the differential diagnosis of sudden hearing loss.

Cited by 8 publications

References 11 publications

Sensorineural Hearing Loss in Juvenile CML: A Rare Case Report in Surabaya, Indonesia

Sensorineural Hearing Loss in Juvenile CML: A Rare Case Report in Surabaya, Indonesia

Our results on sudden hearing loss and hyperbaric oxygen therapy role in recovery

Sudden Sensorineural Hearing Loss Associated with Nutritional Anemia: A Nested Case–Control Study Using a National Health Screening Cohort

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