Hearing loss due to mumps.

Hall, Raelene A.; Richards, H. G. H.

doi:10.1136/adc.62.2.189

Cited by 58 publications

(18 citation statements)

References 3 publications

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“…Severe permanent sequelae are uncommon. However there are significant potential complications including (Galbraith et al, 1982;Hall and Richards, 1987;Plotkin, 2004):…”

Section: The Probability Of Exposure Leading To Infection and Signifimentioning

confidence: 98%

“…Fig. 3 outlines the estimated proportion of susceptibles in these birth cohorts, based on the estimated impact of MMR campaigns and routine vaccination in Scotland during the period 1979-1991, and data from an age-stratified serological study for birth cohorts 1979-1987in England (Farrington and Kanaan, 2001. For the cohorts 1983-1986 (ages 18-21 years in 2004) no vaccine uptake data were available, but the rate was assumed to be 81%, the same as for those born in 1987, for which data were available.…”

Section: The Proportion Of Susceptibles In the Populationmentioning

confidence: 99%

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Increasing incidence of mumps in Scotland: Options for reducing transmission

Donaghy

Cameron

Friederichs

2006

Journal of Clinical Virology

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“…Severe permanent sequelae are uncommon. However there are significant potential complications including (Galbraith et al, 1982;Hall and Richards, 1987;Plotkin, 2004):…”

Section: The Probability Of Exposure Leading To Infection and Signifimentioning

confidence: 98%

Section: The Proportion Of Susceptibles In the Populationmentioning

confidence: 99%

Increasing incidence of mumps in Scotland: Options for reducing transmission

Donaghy

Cameron

Friederichs

2006

Journal of Clinical Virology

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“…Symptoms are normally benign and not life threatening; however, complications necessitating hospitalization may occur following MuV infection in approximately 10% of cases (12). Complications include pancreatitis, orchitis, oophoritis, mastitis, and neurological involvement (meningoencephalitis), which can result in deafness and other severe neurological sequelae (13,21). Invasion of the central nervous system (CNS) by MuV appears in Ͼ50% of patients with clinical mumps as evidenced by cerebrospinal fluid (CSF) pleocytosis; however, symptomatic CNS infection (aseptic meningitis) is much less frequent, occurring in Ͻ10% of cases, and encephalitis occurs in Ͻ1% of mumps cases (5).…”

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confidence: 99%

Molecular Epidemiological Evaluation of the Recent Resurgence in Mumps Virus Infections in Ireland

et al. 2010

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“…More rarely, clinical manifestations involve encephalitis (31, 38), cerebellar ataxia (12), and transverse myelitis and poliomyelitis-like disease (29,33). While symptoms are typically transient, CNS infection can produce significant morbidity (in such manifestations as, e.g., deafness [20,36,57]) and mortality, particularly in the case of encephalitis (38). Despite the clinical significance of mumps virus and the widespread international use of a number of mumps virus vaccines, little is known about the genetic basis for mumps virus attenuation or virulence.…”

mentioning

confidence: 99%

Changes in Mumps Virus Gene Sequence Associated with Variability in Neurovirulent Phenotype

Rubin

Amexis

Pletnikov

et al. 2003

J Virol

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Mumps virus is highly neurotropic and, prior to widespread vaccination programs, was the major cause of viral meningitis in the United States. Nonetheless, the genetic basis of mumps virus neurotropism and neurovirulence was until recently not understood, largely due to the lack of an animal model. Here, nonneurovirulent (Jeryl Lynn vaccine) and highly neurovirulent (88-1961 wild type) mumps virus strains were passaged in human neural cells or in chicken fibroblast cells with the goal of neuroadapting or neuroattenuating the viruses, respectively. When tested in our rat neurovirulence assay against the respective parental strains, a Jeryl Lynn virus variant with an enhanced propensity for replication (neurotropism) and damage (neurovirulence) in the brain and an 88-1961 wild-type virus variant with decreased neurotropic and neurovirulent properties were recovered. To determine the molecular basis for the observed differences in neurovirulence and neuroattenuation, the complete genomes of the parental strains and their variants were fully sequenced. A comparison at the nucleotide level associated three amino acid changes with enhanced neurovirulence of the neuroadapted vaccine strain: one each in the nucleoprotein, matrix protein, and polymerase and three amino acid changes with reduced neurovirulence of the neuroattenuated wild-type strain: one each in the fusion protein, hemagglutinin-neuraminidase protein, and polymerase. The potential role of these amino acid changes in neurotropism, neurovirulence, and neuroattenuation is discussed.Mumps virus is a 15.3-kb enveloped, nonsegmented, negative-strand RNA virus in the Paramyxoviridae family. The mumps virus genome organization is 3Ј NP-P-M-F-SH-HN-L 5Ј, in which the abbreviations represent the genes encoding the following proteins: NP, nucleoprotein; P, phosphoprotein; M, matrix protein; F, fusion protein; SH, small hydrophobic protein; HN, hemagglutinin-neuraminidase protein; and L, polymerase (16). The virus causes mumps, an acute communicable viral disease typical of childhood. Mumps virus is transmitted through oropharyngeal secretions, with primary virus replication in the respiratory mucosa. Following the development of viremia, mumps virus infects a number of targets, including the central nervous system (CNS), and was a common cause of viral meningitis in the prevaccine era (6). The most common neurological manifestation of CNS infection is aseptic meningitis (23, 37). More rarely, clinical manifestations involve encephalitis (31, 38), cerebellar ataxia (12), and transverse myelitis and poliomyelitis-like disease (29,33). While symptoms are typically transient, CNS infection can produce significant morbidity (in such manifestations as, e.g., deafness [20,36,57]) and mortality, particularly in the case of encephalitis (38). Despite the clinical significance of mumps virus and the widespread international use of a number of mumps virus vaccines, little is known about the genetic basis for mumps virus attenuation or virulence.In this study, we sought to iden...

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Hearing loss due to mumps.

Cited by 58 publications

References 3 publications

Increasing incidence of mumps in Scotland: Options for reducing transmission

Increasing incidence of mumps in Scotland: Options for reducing transmission

Molecular Epidemiological Evaluation of the Recent Resurgence in Mumps Virus Infections in Ireland

Changes in Mumps Virus Gene Sequence Associated with Variability in Neurovirulent Phenotype

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