Hearing loss due to metastasis of gastric cancer to temporal bone: A case report

Cao, Xiangming; Cui, Fangbo; Wei, Jia; Wang, Qing; Deng, Li; Liu, Bao Rui; Shen, Wei

doi:10.3892/ol.2016.4084

Cited by 2 publications

(3 citation statements)

References 17 publications

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“…Of those, 2,308 were excluded from review, and the remaining 576 full‐text articles were scrutinized for eligibility. After excluding 467 articles, a total of 109 articles published from 1948 to 2019 remained in the final analysis 4–6,9–11,14–116 . This provided a total of 255 individual cases for data extraction.…”

Section: Resultsmentioning

confidence: 99%

Metastatic Disease of the Temporal Bone: A Contemporary Review

et al. 2020

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Objectives To identify the frequency and primary site of metastatic pathologies to the temporal bone and characterize the associated symptomatology. Methods The MEDLINE, Embase, and Web of Science databases were systematically reviewed according to the PRISMA guidelines to identify all cases of pathologically confirmed distant temporal bone metastases published with English translation until October 2019. Descriptive statistics were performed. Results Out of 576 full‐length articles included for review, 109 met final criteria for data extraction providing 255 individual cases of distant temporal bone metastases. There was a male predominance (54.9%) with median age of 59.0 years (range 2–90). The most common locations of primary malignancy included the breasts (19.6%), lungs (16.1%), and prostate (8.6%). Most tumors were carcinomas of epithelial origin (75.3%) and predominantly adenocarcinoma (49.4%). The commonest metastatic sites encountered within the temporal bone were the petrous (72.0%) and mastoid (49.0%) portions. Bilateral temporal bone metastases occurred in 39.8% of patients. Patients were asymptomatic in 32.0% of cases. Symptomatic patients primarily reported hearing loss (44.3%), facial palsy (31.2%), and otalgia (16.6%) for a median duration of 1 month. Petrous lesions were associated with asymptomatic cases (P = .001) while mastoid lesions more often exhibited facial palsy (P = .026), otalgia (P < .001), and otorrhea (P < .001). Non‐carcinomatous tumors were associated with petrosal metastasis (P = .025) and asymptomatic cases (P = .109). Carcinomatous metastases more often presented with otalgia (P = .003). Conclusions Temporal bone metastasis is uncommon but should be considered in patients with subacute otologic symptoms or facial palsy and history of distant malignancy. Laryngoscope, 131:1101–1109, 2021

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Section: Resultsmentioning

confidence: 99%

Metastatic Disease of the Temporal Bone: A Contemporary Review

et al. 2020

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“…According to 3 case reports, initial clinical manifestations associated with bone metastasis are extremely rare in patients with gastric cancer ( 6 – 8 ). In the present study, increased ALP levels were noted by routine laboratory survey in case 1, without any symptoms associated with bone involvement, and swelling in the right CMC joint of the thumb due to trapezium metastasis was noted in case 2.…”

Section: Discussionmentioning

confidence: 99%

“…Bone metastasis is usually recognized as parallel disease recurrence following surgery ( 1 – 3 ) or progression during follow-up, and occurs in the late stage of the disease ( 2 – 4 ). Initial (or simultaneous) presentation of bone metastasis, particularly in asymptomatic gastric cancer, is extremely rare ( 5 – 8 ). The present study describes two cases of gastric cancer initially presenting with an increased serum alkaline phosphatase (ALP) level without any clinical symptoms and as a swelling in the right carpometacarpal joint of the thumb, respectively.…”

Section: Introductionmentioning

confidence: 99%

Gastric cancer initially presenting as bone metastasis: Two case reports and a literature review

et al. 2018

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Gastric cancer frequently spreads to the regional lymph nodes, liver and lungs following surgery or late in the clinical course. However, an initial clinical presentation of bone metastasis in gastric cancer patients is relatively rare. The current study presents two cases of gastric cancer diffusely metastasized to the spinal vertebrae and with a single metastasis to the trapezium, respectively. The initial presentations were an increased alkaline phosphatase level without any symptoms associated with bone metastasis in the first case and a swelling in the right carpometacarpal joint of the thumb in the second case. These clinical manifestations are also extremely rare in gastric cancer with bone metastasis. The study emphasizes that a diagnosis of gastric cancer should be considered in patients with increased alkaline phosphatase without clinical symptoms or with a single bone metastasis.

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Hearing loss due to metastasis of gastric cancer to temporal bone: A case report

Cited by 2 publications

References 17 publications

Metastatic Disease of the Temporal Bone: A Contemporary Review

Metastatic Disease of the Temporal Bone: A Contemporary Review

Gastric cancer initially presenting as bone metastasis: Two case reports and a literature review

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