Gastric cancer initially presenting as bone metastasis: Two case reports and a literature review

Gomi, Daisuke; Fukushima, Toshirou; Kobayashi, Takashi; Sekiguchi, Nodoka; Sakamoto, Akiyuki; Mamiya, Keiko; Koizumi, Tomonobu

doi:10.3892/ol.2018.9393

Cited by 7 publications

(5 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Patients with progressive gastric cancer experience several symptoms, including anorexia, fatigue, abdominal distension, and dyspnea, which may worsen the general condition of the patient [13]. Cases presenting with bone metastases without any preceding gastrointestinal symptoms make diagnosis particularly difficult [14][15][16]. In the present case, the patient had no abdominal symptoms despite an advanced gastric cancer.…”

Section: Case Reports In Orthopedicsmentioning

confidence: 88%

Successful Neurological Recovery with Multimodality Therapy without Surgery for Spinal Metastases from Advanced Gastric Cancer

Kinoshita

Kamoda

Ishii

et al. 2020

Case Reports in Orthopedics

View full text Add to dashboard Cite

Advanced gastric cancer with bone metastasis has a very poor prognosis with short median survival. To the best of our knowledge, no reports in literature have described extensive recovery of paralysis with multimodality treatment without surgery in these cases. This report describes the case of a 52-year-old severely paralyzed female patient with spinal metastasis from advanced gastric cancer. She was inoperable, owing to a large thrombus in the inferior vena cava; alternative multimodality treatments, including chemotherapy and radiotherapy, were administered. The paralysis and the bladder and rectal dysfunction improved considerably. In addition, the performance status (PS) and Frankel grade also improved dramatically, from 4 to 1 and grade B to D, respectively. At 1 year after initiation of treatment, she is ambulatory. Patients with poor PS are often offered palliative therapy. However, this case demonstrates that poor PS solely due to paralysis from spinal metastasis may necessitate multimodality treatment instead of palliative care.

show abstract

Section: Case Reports In Orthopedicsmentioning

confidence: 88%

Successful Neurological Recovery with Multimodality Therapy without Surgery for Spinal Metastases from Advanced Gastric Cancer

Kinoshita

Kamoda

Ishii

et al. 2020

Case Reports in Orthopedics

View full text Add to dashboard Cite

show abstract

“…Additionally, no data about the outcomes of these patients were reported in the landmark phase II and III trials in the metastatic GC setting (see above). Therefore, the most representative data regarding the prognosis of patients with GC and bone metastasis came from the same retrospective analysis already cited in the previous Section 3.1 [ 17 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 ] ( Table 1 ).…”

Section: Clinical Overview On Bone Metastases From Gastric Cancermentioning

confidence: 99%

Bone Metastases from Gastric Cancer: What We Know and How to Deal with Them

Petrillo

Giunta

Pappalardo

et al. 2021

JCM

View full text Add to dashboard Cite

Gastric cancer (GC) is the third cause of cancer-related death worldwide; the prognosis is poor especially in the case of metastatic disease. Liver, lymph nodes, peritoneum, and lung are the most frequent sites of metastases from GC; however, bone metastases from GC have been reported in the literature. Nevertheless, it is unclear how the metastatic sites may affect the prognosis. In particular, knowledge about the impact of bone metastases on GC patients’ outcome is scant, and this may be related to the rarity of bone lesions and/or their underestimation at the time of diagnosis. In fact, there is still a lack of specific recommendation for their detection at the diagnosis. Then, the majority of the evidences in this field came from retrospective analysis on very heterogeneous study populations. In this context, the aim of this narrative review is to delineate an overview about the evidences existing about bone metastases in GC patients, focusing on their incidence and biology, the prognostic role of bone involvement, and their possible implication in the treatment choice.

show abstract

“…Gastric cancers, which are malignant tumors derived from epithelial cells of the gastric mucosa, have one of the highest cancer incidence rates in the world (Shan et al, 2019). Unfortunately, the proliferation and metastasis of gastric cancers represent significant obstacles to their treatment (Gomi et al, 2018; Petrova et al, 2016; Qiu et al, 2018). In addition, gastric cancer is prone to develop resistance to chemotherapy drugs, leading to the weakened efficacy of chemotherapies (Karimi et al, 2014; Song et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

“…Unfortunately, the proliferation and metastasis of gastric cancers represent significant obstacles to their treatment (Gomi et al, 2018;Petrova et al, 2016;Qiu et al, 2018). In addition, gastric cancer is prone to develop resistance to chemotherapy drugs, leading to the weakened efficacy of chemotherapies (Karimi et al, 2014;Song et al, 2017).…”

mentioning

confidence: 99%

Peimine‐induced apoptosis and inhibition of migration by regulating reactive oxygen species‐mediated MAPK/STAT3/NF‐κB and Wnt/β‐catenin signaling pathways in gastric cancer MKN‐45 cells

Zhang

Liu

Cao

et al. 2022

Drug Development Research

View full text Add to dashboard Cite

Peimine (PM), a natural product extracted from Fritillaria, has anti‐inflammatory, drug resistance reversal, and other pharmacological effects. The purpose of this study was to investigate the antitumor effects and the molecular mechanisms of PM using gastric cancer MKN‐45 cells. Cell counting kit‐8 assays were used to evaluate the viability of gastric cancer cells after treatment with PM. The results showed that PM significantly reduced the activity of gastric cancer cells, and the effect was most obvious in MKN‐45 cells. Annexin V‐FITC/propidium iodide staining and flow cytometry were used to assess apoptosis of MKN‐45 cells after PM treatment. Our results showed that PM‐induced apoptosis of MKN‐45 cells. Flow cytometry was also used to determine the mitochondrial membrane potential and reactive oxygen species (ROS) levels, and to assess PM‐induced cell‐cycle arrest. Additionally, Western blot was used to analyze the expression of signaling pathway proteins and the relationship between apoptosis and ROS accumulation. Our findings showed that PM destroyed the mitochondria by diminishing the mitochondrial membrane potential. In addition, PM regulated the mitogen‐activated protein kinase (MAPK), signal transducer and activator of transcription 3, and nuclear factor kappa‐B signaling pathways by promoting the accumulation of ROS in MKN‐45 cells. PM also caused cell‐cycle arrest in the G2/M phase by increasing ROS accumulation. Furthermore, PM inhibited cell migration by regulating the Wnt/β‐catenin pathway. In conclusion, PM plays an anticancer role through endogenous apoptosis pathways and by inhibiting cell migration, and it has the potential to be a useful treatment for gastric cancers.

show abstract

Gastric cancer initially presenting as bone metastasis: Two case reports and a literature review

Cited by 7 publications

References 13 publications

Successful Neurological Recovery with Multimodality Therapy without Surgery for Spinal Metastases from Advanced Gastric Cancer

Successful Neurological Recovery with Multimodality Therapy without Surgery for Spinal Metastases from Advanced Gastric Cancer

Bone Metastases from Gastric Cancer: What We Know and How to Deal with Them

Peimine‐induced apoptosis and inhibition of migration by regulating reactive oxygen species‐mediated MAPK/STAT3/NF‐κB and Wnt/β‐catenin signaling pathways in gastric cancer MKN‐45 cells

Contact Info

Product

Resources

About