Hearing Loss, Auditory Neuropathy, and Neurological Co-morbidity in Children with Birthweight &lt;750 g

Martínez-Cruz, Carlos F.; Alonso-Themann, Patricia García; Poblano, Adrián; Ochoa-López, Juan M.

doi:10.1016/j.arcmed.2012.08.007

Cited by 19 publications

(24 citation statements)

References 35 publications

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“…We identified 11 observational studies examining the association of furosemide and SNHL in premature infants: 5 retrospective cohort studies and 6 case-control studies [ 19 – 29 ]. The results of the studies were mixed; however, an association between furosemide and SNHL was found in 8 of the 11 observational studies [ 19 – 23 , 25 , 27 , 29 ]. Two cohort studies and one case-control study did not identify an association with furosemide and SNHL [ 24 , 26 , 28 ].…”

Section: Resultsmentioning

confidence: 99%

Association between furosemide in premature infants and sensorineural hearing loss and nephrocalcinosis: a systematic review

Jackson

Taylor

Selewski

et al. 2018

matern health, neonatol and perinatol

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Furosemide is a potent loop diuretic commonly and variably used by neonatologists to improve oxygenation and lung compliance in premature infants. There are several safety concerns with use of furosemide in premature infants, specifically the risk of sensorineural hearing loss (SNHL), and nephrocalcinosis/nephrolithiasis (NC/NL). We conducted a systematic review of all trials and observational studies examining the association between these outcomes with exposure to furosemide in premature infants.We searched MEDLINE, EMBASE, CINAHL, and clinicaltrials.gov. We included studies reporting either SNHL or NC/NL in premature infants (< 37 weeks completed gestational age) who received at least one dose of enteral or intravenous furosemide. Thirty-two studies met full inclusion criteria for the review, including 12 studies examining SNHL and 20 studies examining NC/NL. Only one randomized controlled trial was identified in this review. We found no evidence that furosemide exposure increases the risk of SNHL or NC/NL in premature infants, with varying quality of studies and found the strength of evidence for both outcomes to be low. The most common limitation in these studies was the lack of control for confounding factors.The evidence for the risk of SNHL and NC/NL in premature infants exposed to furosemide is low. Further randomized controlled trials of furosemide in premature infants are urgently needed to adequately assess the risk of SNHL and NC/NL, provide evidence for improved FDA labeling, and promote safer prescribing practices.Electronic supplementary materialThe online version of this article (10.1186/s40748-018-0092-2) contains supplementary material, which is available to authorized users.

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Section: Resultsmentioning

confidence: 99%

Association between furosemide in premature infants and sensorineural hearing loss and nephrocalcinosis: a systematic review

Jackson

Taylor

Selewski

et al. 2018

matern health, neonatol and perinatol

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“…Aunque el peso no mostró un resultado estadísticamente significativo, tanto en niñas como en niños, encontramos un OR < 1. Creemos que la alta incidencia de HNS reportada por otros autores (2,3,10,13) no se atribuye al bajo peso, sino a las complicaciones derivadas de ella, como sepsis, hipoxemia, displasia broncopulmonar, hemorragia intraventricular y el tratamiento con diuréticos de asa (furosemida), entre otras.…”

Section: Discussionunclassified

Factores de riesgo para el desarrollo de hipoacusia neurosensorial congénita: análisis de 10 años

Gelves

Perdigón

Monje

et al. 2018

Acta otorrinolaringol cir cabeza cuello

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Objetivo: Obtener datos actuales de la incidencia de Hipoacusia Neurosensorial (HNS) y determinar la fuerza de asociación de factores de riesgo en pacientes con HNS. Diseño del estudio: Observacional, analítico de casos y controles. Métodos: Pacientes con HNS, diagnosticados mediante potenciales evocados auditivos automatizados en la Fundación CINDA, entre los años 2002 y 2012, pareados por edad gestacional y peso para una relación caso-control 1:2. Resultados: De 11.774 historias clínicas,se detectaron 563 (4,78%) pacientes con HNS. Se encontró riesgo atribuible (odds ratio, OR) estadísticamente significativo para ventilación mecánica por más de cinco días (OR = 24,2), síndromes asociados a HNS (OR = 13,7), malformación craneofacial (OR = 7,9), antecedente familiar para HNS temprana (OR = 5,68), exposición a ototóxicos prenatales (OR = 3,13), exanguinotransfusión (OR = 2,02) e infecciones por el perfil Storch (OR = 1,60). Conclusiones: Nuestros resultados indican que la ventilación mecánica por más de cinco días, los síndromes asociados a HNS y las malformaciones craneofaciales presentan mayor fuerza de asociación para desarrollar HNS que otros factores de riesgo. Estos datos son fundamentales para organizar programas dirigidos a estos grupos de alto riesgo.)

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“…after premature birth or hyperbilirubinemia, can also be mistaken for greater hearing loss than is later found. This means that a plausibility check using otoacoustic emissions or subjective audiometry is always necessary [ 30 ], [ 44 ], [ 53 ].…”

Section: Diagnostics and Causes Of Early Childhood Hearing Disordermentioning

confidence: 99%

Hearing impairment and language delay in infants: Diagnostics and genetics

Lang‐Roth

2014

GMS Current Topics in Otorhinolaryngology - Head and Neck Surgery; 13:Doc05; ISSN 1865-1011

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Hearing Loss, Auditory Neuropathy, and Neurological Co-morbidity in Children with Birthweight <750 g

Cited by 19 publications

References 35 publications

Association between furosemide in premature infants and sensorineural hearing loss and nephrocalcinosis: a systematic review

Association between furosemide in premature infants and sensorineural hearing loss and nephrocalcinosis: a systematic review

Factores de riesgo para el desarrollo de hipoacusia neurosensorial congénita: análisis de 10 años

Hearing impairment and language delay in infants: Diagnostics and genetics

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