Hearing Disorders in Patients with Insulin-Dependent Diabetes mellitus

Parving, Agnete; Elberling, Claus; Balle, Viggo; Parbo, J.; Dejgaard, A.; Parving, Hans‐Henrik

doi:10.3109/00206099009072844

Cited by 50 publications

(33 citation statements)

References 11 publications

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“…Diabetes has been established as a risk factor for HI in epidemiologic and pathologic studies (Parving et al, 1990;Sasso et al, 1999;Varkonyi et al, 2002;Ologe and Okoro, 2005;Vaughan et al, 2006;Sakuta et al, 2007). The mechanism by which diabetes could result in HI is not clear.…”

Section: Discussionmentioning

confidence: 96%

Three decade change in the prevalence of hearing impairment and its association with diabetes in the United States

Cheng

Gregg

Saaddine

et al. 2009

Preventive Medicine

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Section: Discussionmentioning

confidence: 96%

Three decade change in the prevalence of hearing impairment and its association with diabetes in the United States

Cheng

Gregg

Saaddine

et al. 2009

Preventive Medicine

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“…Pooled data further indicate that the risk of hearing loss is increased for hospital-based populations with more severe DM compared with DM in the general population (Horikawa et al 2013). Effects of DM have also been shown on the auditory brainstem response, ABR (Parving et al 1990; Bayazit et al 2000; Durmus et al 2004; Diaz de Leon-Morales et al 2005; Vaughn et al 2007b; Konrad-Martin et al 2010; Akinpelu et al 2014a). Konrad-Martin et al (2010) found, primarily among younger patients (< 50 years) dependent on insulin to manage their DM (IDDM participants), lower amplitude of ABR wave V, longer latency of waves III and V, and prolonged I-V interpeak latency interval compared with control participants, indicative of central auditory system effects.…”

Section: Introductionmentioning

confidence: 96%

Diabetes-Associated Changes in Cortical Auditory-Evoked Potentials in Relation to Normal Aging

et al. 2016

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OBJECTIVES-(1) Characterize the influence of type 2 diabetes mellitus (DM) on cortical auditory evoked potentials (CAEPs) separate from the effects of normal aging; and (2) determine if the disease-related effects are modified by insulin dependence. DESIGN-A cross-sectional study was conducted in a large cohort of Veterans to investigate the relationships among type 2 DM, age and CAEPs in randomly selected participants with (N=108) and without (N=114) the disease and who had no more than a moderate hearing loss. Participants with DM were classified as insulin-dependent (IDDM, N=47) or non-insulin-dependent (NIDDM, N=61). Other DM measures included concurrent serum glucose, HbA1c and duration of disease. CAEPs were evoked using a passive homogeneous paradigm (single repeating stimulus) by suprathreshold tones presented to the right ear, left ear, or both ears. Outcome measures were adjusted for the pure tone threshold average (PTA) for frequencies of 0.5, 1, and 2 kHz and analyzed for differences in age effects between participant groups using multiple regression.RESULTS-There is little variation across test ear conditions (left, right, binaural) on any CAEP peak in any of the groups. Among no-DM controls, P2 latency increases about 9 ms per decade of life. DM is associated with an additional delay in the P2 latency of 7 and 9 ms for the IDDM and NIDDM groups, respectively. Moreover, the slope of the function relating P2 latency with age is similar across participant groups and thus the DM effect appears constant across age. Effects on N1 latency are considerably weaker, with age effects of less than 4 ms per decade across all groups, and DM effects of only 2 (IDDM) or 3 ms (NIDDM). In the NIDDM group, the slope relating N1 latency to age is steeper relative to that observed for the no-DM group, providing some evidence of accelerated "aging" for this CAEP peak. DM does not substantially reduce N1-P2 U.S. Department of Veterans Affairs VA Author ManuscriptVA Author Manuscript VA Author Manuscript amplitude and age relationships with N1-P2 amplitude are effectively absent. There is no association between PTA at .5, 1, and 2 kHz and any aspect of CAEPs in this cohort.CONCLUSIONS-In a large cohort of Veterans, we found that type 2 DM is associated with prolonged N1 and P2 latencies regardless of whether insulin is required to manage the disease and independent of peripheral hearing thresholds. The DM-related effects on CAEP latencies are three fold greater for P2 compared with N1, and there is little support that at the cortical level, IDDM participants had poorer responses compared with NIDDM participants, although their responses were more variable. Overall, these results indicate that DM is associated with slowed pre-attentive neural conduction. Moreover, the observed 7-9 ms P2 latency delay due to DM is substantial compared with normal age changes in P2, which are 9 ms per decade of life in this cohort. Results also suggest that whereas N1 latency changes with age are more pronounced among individuals w...

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“…Metabolic factors, such as the accumulation of sorbitol and fructose in the nerve tissue, vascular abnormalities, and other mechanisms, have been proposed to underlie the pathogenesis of diabetic neuropathy (13). A series of electrophysiological studies further revealed retrocochlear pathologies in diabetes, although the subjects' pure tone threshold was unaffected (14Y18).…”

Section: Introductionmentioning

confidence: 98%