Risk of Developing Sudden Sensorineural Hearing Loss in Diabetic Patients

Lin, Shih Wei; Lin, Yong-Song; Weng, Shih‐Feng; Chou, Chien Wen

doi:10.1097/mao.0b013e318271397a

Cited by 72 publications

(85 citation statements)

References 28 publications

(23 reference statements)

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“…We previously found that DM was correlated with a greater risk of developing ISSNHL. However, the effect of the comorbid DM on the prognosis of ISSNHL remains controversial.…”

Section: Discussionmentioning

confidence: 93%

“…[8][9][10][11][12] Many medical risk factors of ISSNHL have been proposed in the literature, for example, hypertension (HTN), diabetes mellitus (DM), hypercholesterolemia (Hch), cerebrovascular disease (CVD), coronary artery disease (CAD), chronic kidney disease (CKD), and anemia. [13][14][15][16] However, reports on the effect of these major comorbidities on the prognosis of ISSNHL contain several discrepancies. For example, comorbid microvascular pathology with hyperglycemia and Hch was reported to be an indicator of a better hearing prognosis.…”

Section: Introductionmentioning

confidence: 99%

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Effect of comorbid diabetes and hypercholesterolemia on the prognosis of idiopathic sudden sensorineural hearing loss

Lin

Lee

et al. 2015

The Laryngoscope

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“…We previously found that DM was correlated with a greater risk of developing ISSNHL. However, the effect of the comorbid DM on the prognosis of ISSNHL remains controversial.…”

Section: Discussionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Effect of comorbid diabetes and hypercholesterolemia on the prognosis of idiopathic sudden sensorineural hearing loss

Lin

Lee

et al. 2015

The Laryngoscope

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“…These co-morbidities might interfere with the microvascular supply of the inner ear and lead to hearing loss. Although their effect on prognosis of the disease is not well established, it may be speculated that negative prognostic effect may occur (17,18). Thus, despite steroids seeming to have no additional benefit in this paper, studies on more homogenous patient populations might contribute to the knowledge.…”

Section: Discussionmentioning

confidence: 99%

“…However, most of the time, hearing loss does not recover without treatment, and up to 10% of the cases may experience worsening of hearing despite treatment; therefore, clinicians usually do not take the risk of leaving the patient untreated (3,6,7). Multidrug therapy, also known as "shotgun" therapy, is the most common treatment of choice in SSNHL (6,17). This uncertainty leads to the investigation of efficacy of commonly used agents, particularly systemic steroids.…”

Section: Discussionmentioning

confidence: 99%

Prognostic Factors in Sudden Sensorineural Hearing Loss

Atay¹,

Kayahan²,

Çınar³

et al. 2016

Balkan Med J

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Background: Sudden sensorineural hearing loss (SSNHL) is still a complex and challenging process which requires clinical evidence regarding its etiology, treatment and prognostic factors. Therefore, determination of prognostic factors might aid in the selection of proper treatment modality. Aims: The aim of this study is to analyze whether there is correlation between SSNHL outcomes and (1) systemic steroid therapy, (2) time gap between onset of symptoms and initiation of therapy and (3) audiological pattern of hearing loss. Study Design: Retrospective chart review. Methods: Patients diagnosed at our clinic with SSNHL between May 2005 and December 2011were reviewed. A detailed history of demographic features, side of hearing loss, previous SSNHL and/or ear surgery, recent upper respiratory tract infection, season of admission, duration of symptoms before admission and the presence of co-morbid diseases was obtained. Radiological and audiological evaluations were recorded and treatment protocol was assessed to determine whether systemic steroids were administered or not. Treatment started ≤5 days was regarded as "early" and >5 days as "delayed". Initial audiological configurations were grouped as "upward sloping", "downward sloping", "flat" and "profound" hearing loss. Significant recovery was defined as thresholds improved to the same level with the unaffected ear or improved ≥30 dB on average. Slight recovery was hearing improvement between 10-30dB on average. Hearing recovery less than 10 dB was accepted as unchanged. Results: Among the 181 patients who met the inclusion criteria, systemic steroid was administered to 122 patients (67.4%), whereas 59 (32.6%) patients did not have steroids. It was found that steroid administration did not have any statistically significant effect in either recovered or unchanged hearing groups. Early treatment was achieved in 105 patients (58%) and 76 patients (42%) had delayed treatment. Recovery rates were no different in these two groups; however, when unchanged hearing rates were compared, it was statistically significantly lower in the early treatment group (p<0.05). When hearing outcomes were compared according to initial audiological pattern, significant recovery and unchanged hearing rates did not differ between groups; however, slight recovery rate was highest in the "flat" type audiological configuration (p<0.05). Conclusion: According to this patient series, oral steroid therapy does not have any influence on the outcomes of SSNHL. However, mid-frequency hearing loss of flat type and initiation of treatment earlier than 5 days from the onset of symptoms, seem to have positive prognostic effects. Further randomized controlled subject groups might contribute to determine prognostic factors of SSNHL.

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“…Diabetes is a well‐established risk factor for atherosclerosis and microvascular disorders in the coronary, cerebral, and peripheral regions . A retrospective population‐based cohort study demonstrated that diabetes was associated with an increased risk of developing SSHL, and the presence of coronary heart disease or retinopathy comorbidities in diabetic patients increases the risk of developing SSHL . Moreover, the severity of diabetes increases the risk of SSHL.…”

Section: Discussionmentioning

confidence: 99%