Hearing defects in cystic fibrosis

Fritze, W.; Götz, M.; Stur, O; Zweymüller, E

doi:10.1007/bf00440498

Cited by 10 publications

(3 citation statements)

References 3 publications

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“…Conversely, Kulczycki et al reported a 27% incidence of mild conductive hearing loss in 41 children with CF, suggesting that the expected incidence of hearing loss was higher than that found in a similar group of individuals without CF [8]. Despite these discrepancies, the majority of hearing loss reported in patients with CF is conductive in nature and suspected to be related to otitis media and Eustachian tube dysfunction [8][9][10]27,29,30]. Our data support these conclusions-we found that CHL was the most common type of defined hearing loss, and that otitis media, Eustachian tube dysfunction and otorrhea were positive predictors of hearing loss.…”

Section: Discussionmentioning

confidence: 99%

Audiometric assessment of pediatric patients with cystic fibrosis

Kreicher

Bauschard

Clemmens

et al. 2018

Journal of Cystic Fibrosis

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This is the largest comprehensive analysis of all types of hearing loss in pediatric patients with CF. Our data suggest that children with more severe sinus disease may be at lower risk for inflammatory middle ear disease and subsequent hearing loss. Patients who develop complications of CF such as diabetes should be monitored frequently, and the use of ototoxic drugs should be limited if possible.

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Section: Discussionmentioning

confidence: 99%

Audiometric assessment of pediatric patients with cystic fibrosis

Kreicher

Bauschard

Clemmens

et al. 2018

Journal of Cystic Fibrosis

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“…Even a mild hearing impairment (16-40 dB) in children may be detrimental to speech development and communication 40,41 . Several studies have identified a higher prevalence of hearing loss in CF patients; this hearing loss is due to not only ototoxic effects that cause sensorineural hearing loss, but also due to conductive conditions that may be linked with otitis media and ET dysfunction 17,18,[42][43][44] . Accumulating evidence supports that individuals with CF have a higher prevalence of developing otologic disorders, including otitis media 16,19,45,46 .…”

Section: Discussionmentioning

confidence: 99%

A potential acoustic role for CFTR ion channel in conductive hearing loss

Liyanage,

Mun,

Carraro

et al. 2023

Preprint

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Loss-of-function mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene cause cystic fibrosis (CF). The middle ear and eustachian tube could be adversely affected in CF. In this study, we provide evidence of the role of CFTR function in conductive hearing. We developed an in-situ model to determine CFTR dependent fluid secretion in the middle ear using native mouse auditory capsule. A unique middle ear-on-a-chip was developed to address the functional and molecular basis of conductive hearing impairment. Using single-cell transcriptomics, middle ear cell composition and the associated transcriptomic signature were compared between CF and WT groups. A specialized subset of epithelial cells expressed CFTR with an overlapping signature with secretory epithelial cells. Genes related to ciliogenesis, hearing and ossification were significantly altered in CF mice middle ear. Our data suggest that CF middle ear may be at higher risk for conductive hearing loss.

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“…На фоне широкого применения аминогликозидных антибиотиков при МВ нейросенсорная потеря слуха является ожидаемым осложнением, однако, как показали исследования В.В. Бариляк (2012), B. Forman-Franco (1979) и W. Fritze (1973), хроническая нейросенсорная тугоухость среди пациентов с МВ встречается не чаще, чем среди всей общей популяции [13][14][15].…”

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Features of defeat of ent organs at adult patients with CF

et al. 2019

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Among diseases of ENT organs at patients with the CF prevails chronic rhinosinusitis. Stagnation of the infected dense slime in the paranasal sinus and violation of nasal breath aggravates weight of a course of lung pathology. Timely inspection and treatment of pathology of the top airways at patients with CF is necessary. In surgical treatment method of a choice is expanded FESS. This technique allows to keep anatomy of a facial skeleton and to provide a drainage the paranasal sinus. Supervision by the ENT specialist and conservative treatment of a chronic rhinosinusitis has to is carried out during all life of the patient with CF. Continuous use of local mukolitichesky and antibacterial therapy is necessary. As method of delivery of medicines the compressor inhaler with the mode for the chronic rhinosinusitis can serve.

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Hearing defects in cystic fibrosis

Cited by 10 publications

References 3 publications

Audiometric assessment of pediatric patients with cystic fibrosis

Audiometric assessment of pediatric patients with cystic fibrosis

A potential acoustic role for CFTR ion channel in conductive hearing loss

Features of defeat of ent organs at adult patients with CF

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