A potential acoustic role for CFTR ion channel in conductive hearing loss
Pramodha Liyanage,
Kyu-Shik Mun,
Gianni Carraro
et al.
Abstract:Loss-of-function mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene cause cystic fibrosis (CF). The middle ear and eustachian tube could be adversely affected in CF. In this study, we provide evidence of the role of CFTR function in conductive hearing. We developed an in-situ model to determine CFTR dependent fluid secretion in the middle ear using native mouse auditory capsule. A unique middle ear-on-a-chip was developed to address the functional and molecular basis of conductive… Show more
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