Healthcare services relaxing natural selection may contribute to increase of dementia incidence

You, Wenpeng; Henneberg, Renata J.; Henneberg, Maciej

doi:10.1038/s41598-022-12678-4

Cited by 9 publications

(15 citation statements)

References 53 publications

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“…Thus, it is possible to hypothesize a potential link between mutations and muscle variability (Krämer et al 2006). You et al (2022) conclude that mutations are an inevitable consequence of the poor quality of the chemical bonds between the bases that make up DNA. Their number is gradually increasing in humans due to the species' increased exposure to mutagenic agents as well as better health protection.…”

Section: Discussionmentioning

confidence: 99%

Anatomical variations of the flexor carpi ulnaris in the fetal period

Siwek

Krupa

Mrożek

et al. 2023

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Introduction: The Flexor Carpi Ulnaris (FCU) is a part of the palmar the forearm muscle group and one of the most important muscles for upper limb functioning - is responsible for flexion and adduction of the hand at the radio-carpal joint. There are clinically significant but rare anatomical variations of FCU. The variability of the FCU has not been described up to now, and no typology of the muscle based on its more variable terminal attachment has been created. Aim of the study: Determination of FCU muscle typology based on available fetal material. Material and methods: A total of 114 human fetuses (53 female, 61 male) between 117 and 197 days of fetal life were eligible for the study. Preparations were carried out using classical anatomical techniques based on a previously published procedure. Thanks to that significant anthropometric landmarks were visible for the gathering of metric measurements. Metric measurements were taken and statistically analysed using R-Project software. Results: A new typology was created based on variable muscle insertions. Additionally, the presence of an atypically located, additional, separated muscle belly was described. A comparison of measurements of the left upper limb in relation to the right upper limb showed significant differences for forearm length to the anthropometric point of the stylion radiale, limb length, total FCU length and FCU length which means that the left limb is longer than the right limb. A comparison of FCU insertion types between left and right upper limb showed there’s no significant difference between counts of each type. Conclusion: The FCU is a muscle that is easy to palpate and may therefore act as a topographical marker for healthcare professionals. Knowledge of its variability is not only of theoretical importance but also has clinical significance. The current publication demonstrates presence of variability in FCU terminal attachment. Certainly, this topic requires further research and continued work on a detailed understanding of forearm anatomy in the fetal period.

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Section: Discussionmentioning

confidence: 99%

Anatomical variations of the flexor carpi ulnaris in the fetal period

Siwek

Krupa

Mrożek

et al. 2023

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“…The independent variable is the medical-services-associated reduced natural selection (measured with Biological State Index [I bs ]). [28][29][30][33][34][35] It is well-established that CVD is a lifestyle-associated disease 5 ; however, it is known that CVD has multiple aetiologies that may be contributing to the worldwide increase in CVD incidence rate. People could develop CVD at any stage of their life.…”

Section: Data Sourcesmentioning

confidence: 99%

Modern medical services, a double‐edged sword manages symptoms, but accumulates genetic background of cardiovascular diseases: A cross populational analysis of 217 countries

You,

Henneberg

2024

Health Science Reports

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Background and AimsThrough reduced natural selection, measured with Biological State Index (Ibs), modern medicine enables most people to survive well beyond the reproductive lifespan leading to deleterious gene accumulation in population. This study explored the role of reduced natural selection in increasing cardiovascular disease (CVD) incidence worldwide.MethodsCountry‐specific estimates of CVD incidence and the index of reduced natural selection were captured for analysis of their correlation. Aging, affluence, obesity prevalence, and urbanization were considered as the potential confounders in the analyses.ResultsWorldwide, Ibs was significantly correlated with CVD incidence in the bivariate correlation analyses. This relationship remains when the contributing effects from aging, affluence, obesity prevalence, and urbanization are removed in partial correlation model. Multiple linear regression (enter) shows that Ibs is a significant predictor of CVD incidence. Stepwise multiple linear regression selects Ibs as the variable having the second greatest influence on CVD incidence after ageing. Ibs showed a significantly greater correlation with CVD incidence in low‐ and middle‐income countries (LMICs) than in high‐income countries.ConclusionWorldwide, through reducing natural selection, the side effects of healthcare services may have been partially contributing to the increase of CVD incidence worldwide with special regard to LMICs.

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“…The independent variable, Biological State Index (I bs ) was extracted from the previous publications [19,20,[28][29][30][31] I bs has been more and more recognized as an index of the side effects of medical services, which reduce natural selection leading to genetic background accumulation in human population. The side effects of medical services measured with the I bs have been associated with the increase of non-communicable diseases with genetic backgrounds [29], for example adult obesity [19,20], cancers [30], dementia [31] and type 1 diabetic disease [28].…”

Section: Data Collection and Selectionmentioning

confidence: 99%

“…The role of I bs in accumulating detrimental genetic background at population level has been tested with the positive correlations of I bs to cancer incidence [30], dementia incidence [31], type 1 diabetes incidence…”

Section: Introductionmentioning

confidence: 99%

The dilemmatic role of medicine in adolescent obesity from the perspective of reduced natural selection

Henneberg

You

2023

Preprint

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Objective Relaxed natural selection has been indexed with the Biological State Index (Ibs), which indicates the opportunity for an average member of a population to pass genes to the next generation. This study explores the correlation of Ibs to adolescent obesity prevalence.Methods Population level variables (adolescent obesity prevalence, self-calculated Ibs, GDP, urbanization and calories) are extracted from or calculated with the United Nations data agencies for the correlation analyses. To examine the Ibs-adolescent obesity relationship, the five non-normally distributed variables are analysed in curvilinear regression models with raw data and linear regressions with log-transformed data. Countries are grouped for exploring the regional Ibs-adolescent obesity correlations.Results Linear correlation and the first order curvilinear regression identified that Ibs-adolescent obesity correlation is significant, and this relationship remains in the third order curvilinear regression and partial correlation when the confounding effects of GDP, urbanization and calories are removed. Ibs-adolescent obesity correlation also presents in different country groupings. It is highlighted that Ibs-adolescent obesity is significantly stronger in developing countries than developed countries. Stepwise multiple linear regression identified Ibs as the second most influential risk factor for adolescent obesity. Caloric intake does not show significant effects on predicting adolescent obesity in both enter and stepwise regression models.Conclusions Reduced natural selection may drive obesity associated genetic background to accumulate in population through allowing people to participate in reproduction. The magnitude of reduced natural selection correlates with adolescent obesity prevalence. This suggests that reduced natural selection is another major risk factor for adolescent obesity.

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Healthcare services relaxing natural selection may contribute to increase of dementia incidence

Cited by 9 publications

References 53 publications

Anatomical variations of the flexor carpi ulnaris in the fetal period

Anatomical variations of the flexor carpi ulnaris in the fetal period

Modern medical services, a double‐edged sword manages symptoms, but accumulates genetic background of cardiovascular diseases: A cross populational analysis of 217 countries

The dilemmatic role of medicine in adolescent obesity from the perspective of reduced natural selection

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