Healthcare Chip for Checking Health Condition from Analysis of Trace Blood Collected by Painless Needle

Oki, Akio; Takai, Madoka; Ogawa, Hiroki; Takamura, Yuzuru; Fukasawa, Tomonori; Kikuchi, Jun; Ito, Yoshitaka; Ichikı, Takanori; Horiike, Yasuhiro

doi:10.1143/jjap.42.3722

Cited by 43 publications

(39 citation statements)

References 14 publications

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“…The realization of painless needle from mosquito's mechanism of blood withdrawal, lots of research are done to improve the efficiency of the micro-needles for blood delivery from various sizes of needle and designs. Needles are defined as sharp hypodermic needle that has a function to be painless while completing the task of penetrating the human outermost skin to withdraw blood or injecting fluid into the blood stream [1]~ [4]. The advancement of the research leads to the technologies of micro-needles in improving the flow and performance which includes attaching micropump at the microneedle [5].…”

Section: Introductionmentioning

confidence: 99%

Blood-mimicking delivery in polygonal structure of inner quadrupletip microneedle with valveless micro-pump

Ibrahim

Yunos

Rigit

et al. 2017

J. Phys.: Conf. Ser.

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A micropump driven by electrochemically produced short-lived bubbles I V Uvarov, S S Lemekhov, A E Melenev et al. Abstract. This paper presents a titanium quadrupletip micro-needle integrated with a micropump with different inner designs, length and diameter of the micro-channels to measure and maximize the velocity flow in the micro-needle as blood delivered into human body. Titanium is used as the material of the micro-needle which are also the common material in manufacturing of micro-needle. The advancement of micro-needle technologies is improved in penetrating human outermost skin, stratum corneum and further to human blood vessels. The micro-needles with channel inner design of circular, square, hexagon, and dodecagon with quadruple tip designs are drawn with inner diameter parameter of 150μm and 100μm with two different channel length which are 10mm and 25mm. The characteristics of blood delivery in geometrically changed inner designs affect the output velocity in microneedle when the micropump is operating. The results showed that, when it is pumped at 0.04m/s, the blood velocity improved by 5.6% than when the pump is increased by 30% of its capacity. This is due to the backflow generated in the micropump.

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Section: Introductionmentioning

confidence: 99%

Blood-mimicking delivery in polygonal structure of inner quadrupletip microneedle with valveless micro-pump

Ibrahim

Yunos

Rigit

et al. 2017

J. Phys.: Conf. Ser.

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show abstract

“…From the beginning of the realization of painless needle from mosquito's mechanism of blood withdrawal, lots of research is done to improve the efficiency of the micro-needles for drug delivery and blood withdrawal from various sizes of needle and designs. Needles are defined as sharp hypodermic needle that has a function to be painless while completing the task of penetrating the human outermost skin to withdraw blood or injecting fluid into the blood stream [1][2][3][4]. From hypodermic needles to the current conventional micro-needle, the advancement of the researches leads to the technologies of microneedles in improving the flow and performance while completing the task of penetrating the human outermost skin [5].…”

Section: Introductionmentioning

confidence: 99%

Micro-Needle with Polygonal Structure of Micro-Channel for Stress and Blood or Drug Flow Optimization

Ibrahim

Yunos

Watanabe

et al. 2017

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Abstract. This paper presents micro-needle with different tip and inner structure of the needle for optimizations of pain stresses and drug or blood deliveries. The micro-needle comes with several design's parameters of length ranging from 5mm to 50mm and diameter ranging from 100µm to 200µm. A hollow micro-needle with four different tip designs which are 10°, D3-2, D6 and Quadruple are also designed to optimize the pain stresses parameters. In order to improve the flow deliveries, the inner structure of the channel is modified into various polygonal shape which is square, hexagon and dodecagon. It shows that, having less contact surface area between the skin and micro-needle's tip and polygonal shape of inner channel has better performance for both of the objectives. These feasible region of average velocity and stress of the micro-needle have satisfied in determining the best design for tip and inner channel of the micro-needle under certain conditions and constraints. The three-dimensional geometry study had improved the insertions performance and efficiencies in painless drug or blood deliveries.

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“…1,2 Various microfluidic devices for blood analyses have been developed. [3][4][5][6][7][8] These microfluidic devices have the ability to quickly measure analytes from small volumes of blood. For example, immunoassays, which enable the detection of clinically important analytes such as disease biomarkers, are important analytical methods for clinical diagnosis.…”

Section: Introductionmentioning

confidence: 99%

“…[10][11][12][13][14][15][16][17][18][19][20][21][22][23] Plasma has been isolated by various methods: through an external force in the case of centrifugation, 7,10 or through capillary force, 11 dielectrophoresis, 12,13 magnetophoresis 14,15 and acoustophoresis, 16 filtration by microbeads, 17 and others. [18][19][20][21][22] Compact-disk-type microchips for plasma separation utilize centrifugation for accelerating the sedimentation of erythrocytes and metering the plasma or capillary force for the extraction of plasma.…”

Section: Introductionmentioning

confidence: 99%

Microchip-based Plasma Separation from Whole Blood via Axial Migration of Blood Cells

Aota¹,

Takahashi

Mawatari

et al. 2011

ANAL. SCI.

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Healthcare Chip for Checking Health Condition from Analysis of Trace Blood Collected by Painless Needle

Cited by 43 publications

References 14 publications

Blood-mimicking delivery in polygonal structure of inner quadrupletip microneedle with valveless micro-pump

Blood-mimicking delivery in polygonal structure of inner quadrupletip microneedle with valveless micro-pump

Micro-Needle with Polygonal Structure of Micro-Channel for Stress and Blood or Drug Flow Optimization

Microchip-based Plasma Separation from Whole Blood via Axial Migration of Blood Cells

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