“Health status of children with chronic liver disease during the SARS-CoV-2 outbreak: results from a multicentre study”

Giorgio, Angelo Di; Nicastro, Emanuele; Arnaboldi, Sara; Montini, O; Stasio, Flavio Di; D’Antiga, Lorenzo; Gaio, Paola; Fovino, Luca Nai; Cananzi, Mara; Pinon, Michele; Camelli, V.

doi:10.1016/j.clinre.2020.101610

Cited by 12 publications

(13 citation statements)

References 12 publications

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“… [109] More recently, a multicenter study conducted on children with CLD in Northern Italy reported that the majority of children remained healthy during the outbreak, without differences in the susceptibility to SARS-CoV-2 infection, regardless of the underlying CLD. [110] Similar findings came from studies focusing on children on immunosuppressive treatment. [109] As for IBD, an underlying liver disease does not seem an additional risk factor for severe COVID-19.…”

Section: Present and Future Challengessupporting

confidence: 55%

Gastrointestinal, hepatic and pancreatic manifestations of COVID-19 in children

Pegoraro

Trapani

Indolfi

2022

Clinics and Research in Hepatology and Gastroenterology

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Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a well-established respiratory tract pathogen. Recent studies in adults and children have shown an increasing number of patients reporting gastrointestinal manifestations of SARS-CoV-2 infection such as diarrhoea, nausea, vomiting and abdominal pain. SARS-CoV-2 RNA can be detected in faeces for an extended period, even after respiratory samples have tested negative and patients are asymptomatic. However, faecal-oral transmission has not yet been proven. In this article, the latest evidence on gastrointestinal, hepato-biliary, and pancreatic manifestations in children with coronavirus disease-19 and multisystem inflammatory syndrome will be analysed.

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Section: Present and Future Challengessupporting

confidence: 55%

Gastrointestinal, hepatic and pancreatic manifestations of COVID-19 in children

Pegoraro

Trapani

Indolfi

2022

Clinics and Research in Hepatology and Gastroenterology

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“…Their reported data is similar to adults with higher admission rates, pediatric intensive care management, mechanical ventilation, and death in patients with CLD as compared with liver transplant patients. An observational cohort study by Di Giorgio et al 39 contradicted the above result. Their data showed no difference in severity of COVID-19 in patients with liver disease, however they did show a higher observed incidence of infection than the estimated incidence in the population.…”

Section: Discussionmentioning

confidence: 91%

“…Regardless of the potential increased risk, treating patients with pre-existing liver disease is further complicated by the hepatotoxicity of many of the medications used to treat COVID-19 9 , 11 . The adult data supports cirrhosis as a risk factor for severe disease, however again the data in pediatrics is unclear 38 , 39 .When investigating autoimmune hepatitis (AIH) as compared to other etiologies of liver disease there was no difference in rate of severe disease 40 . Similar to IBD, immunosuppression with biologic agents was not a risk factor for severe disease secondary to COVID-19 for patients with AIH 40 .…”

Section: Discussionmentioning

confidence: 99%

COVID-19 and Pediatric Gastroenterology

Taylor

Mallon

2021

Pediatric Clinics of North America

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Synopsis: Pediatric gastroenterologists took on a variety of challenges during the COVID-19 pandemic, including learning about a new disease and how to recognize and manage it, prevent its spread among their patients and health professions colleagues, and make decisions about managing patients with chronic gastrointestinal and liver problems in light of the threat. They adapted their practice to accommodate drastically reduced in-person visits, adopting telehealth, and instituting new protocols to perform endoscopies safely. The workforce pipeline was also affected by the pandemic because of its impact on trainee education, clinical experience, research, and job searches.

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“…Most reports have indicated that children and adolescents comprise a small proportion of confirmed cases, and that these populations are less likely to be severely affected than adults (Castagnoli et al, 2020;Dong et al, 2020a;Ludvigsson, 2020;Rodriguez-Morales et al, 2020). Furthermore, studies have reported a good health status in children with underlying chronic conditions and those on immunosuppressive treatment (Nicastro et al, 2020;Di Giorgio et al, 2021). One study reported 80 deaths in children aged 0-14 years in a population of 137,047,945, resulting in a mortality rate of 0.06 per 100,000 population (Bhopal et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Mortality in children with positive SARS-CoV-2 polymerase chain reaction test: Lessons learned from a tertiary referral hospital in Indonesia

Dewi

Kaswandani

Karyanti

et al. 2021

International Journal of Infectious Diseases

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Background The incidence of COVID-19 is still rapidly increasing, but little is known about the prevalence and characteristics of fatal cases in children in Indonesia. This study aims to describe the characteristics of pediatric COVID-19 cases with fatal outcomes in Indonesia's tertiary referral hospital. Methods This is a cross-sectional study with data collected from the medical records of COVID-19 patients admitted to Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia, from March to October 2020. Results During the study period, 490 patients were admitted and diagnosed with suspected and probable COVID-19. Of these patients, 50 (10.2%) were confirmed to have COVID-19, of which 20 (40%) patients with positive tests for SARS-CoV-2 had a fatal outcome. The fatality was higher in patients ≥10 years old, categorized with severe disease upon admission, with PaO 2 /FiO 2 ratios of ≤300 mmHg and chronic underlying diseases. The most common clinical manifestations were generalized symptoms, while acute respiratory distress syndrome (8/20) and septic shock (7/20) were the two most common causes of death. Increased procalcitonin, D-dimer, lactate dehydrogenase, and presepsin levels were found in all fatal COVID-19 cases. One patient met the criteria of multisystem inflammatory syndrome in children (MIS-C). Conclusion Our work highlights the high mortality rate in pediatric patients positive for the COVID-19 test. Further studies are needed to understand better the role of SARS-CoV-2 in elaborating the mechanisms leading to death in children with comorbidities.

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“Health status of children with chronic liver disease during the SARS-CoV-2 outbreak: results from a multicentre study”

Cited by 12 publications

References 12 publications

Gastrointestinal, hepatic and pancreatic manifestations of COVID-19 in children

Gastrointestinal, hepatic and pancreatic manifestations of COVID-19 in children

COVID-19 and Pediatric Gastroenterology

Mortality in children with positive SARS-CoV-2 polymerase chain reaction test: Lessons learned from a tertiary referral hospital in Indonesia

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