Health Status and Quality of Life in Tuberculosis: Systematic Review of Study Design, Instruments, Measuring Properties and Outcomes

Khan, Sumeera; Tangiisuran, Balamurugan; Imtiaz, Ayesha; Zainal, Hadzliana

doi:10.21767/1791-809x.1000484

Cited by 11 publications

(16 citation statements)

References 37 publications

(81 reference statements)

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“…An objective assessment of patient's QOL attempts to quantify the functional effects of an illness and its consequent therapy on a patient, as perceived by that patient. A wide variety of questionnaires and scales have been employed to evaluate self-rated QOL in patients with active TB [4], [5], [6], [7]. Some of these evaluate QOL holistically, whereas others focus on specific domains like physical health or psychological morbidity.…”

Section: Instruments For Describing and Quantifying Qol In Tbmentioning

confidence: 99%

Quality of life with tuberculosis

Aggarwal

2019

Journal of Clinical Tuberculosis and Other Mycobacterial Diseas

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Tuberculosis diagnosis and treatment currently revolves around clinical features and microbiology. The disease however adversely affects patients’ psychological, economic, and social well-being as well, and therefore our focus also additionally needs to shift towards quality of life (QOL). The disease influences all QOL domains and substantially adds to patient morbidity, and these complex and multidimensional interactions pose challenges in accurately quantifying impairment in QOL. For this review, PubMed database was queried using keywords like quality of life, health status and tuberculosis, and additional publications identified by a bibliographic review of shortlisted articles. Both generic and specific QOL scales show a wide variety of derangements in scores, and results vary across countries and patient groups. In particular, diminished capacity to work, social stigmatization, and psychological issues worsen QOL in patients with tuberculosis. Although QOL has been consistently shown to improve during standard anti-tubercular therapy, many patients continue to show residual impairment. It is also not clear if specific situations like presence of comorbid illnesses, drug resistance, or co-infection with human immunodeficiency virus additionally worsen QOL in these patients. There is a definite need to incorporate QOL assessment as adjunct outcome measures in tuberculosis control programs. Governments and program managers need to step up socio-cultural reforms and health education, and provide additional incentives to patients, to counter impairment in QOL.

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Section: Instruments For Describing and Quantifying Qol In Tbmentioning

confidence: 99%

Quality of life with tuberculosis

Aggarwal

2019

Journal of Clinical Tuberculosis and Other Mycobacterial Diseas

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“…The magnitude of impact on the health outcomes and psychosocial facet in the life of individuals with LTBI has not been well understood to date. In contrast, numerous patient-reported outcome (PRO) instruments with different evaluation features have been used to assess the HRQoL and health utilities of patients with active TB disease [2,3,9,13,14].…”

Section: Introductionmentioning

confidence: 99%

Impact of latent tuberculosis infection on health and wellbeing: a systematic review and meta-analysis

et al. 2021

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The impact of latent tuberculosis infection (LTBI) on health and wellbeing is not well understood. This review aims to evaluate the health and wellbeing of individuals with LTBI. A systematic literature search was performed to assess studies reporting patient-reported outcomes in LTBI management including health-related quality of life (HRQoL), health utilities, disease burden and experience of individuals with LTBI. A pooled analysis was performed to estimate the effect of LTBI on HRQoL.A total of 4464 studies were screened, of which 13 eligible articles describing nine unique studies were included for review. The HRQoL of individuals with LTBI and without tuberculosis (TB) infection were comparable, and better than patients with active TB disease. However, individuals with LTBI reported poorer mental health compared with individuals without TB infection (mean difference −4.16, 95% CI −7.45– −0.87; p=0.01). Qualitative studies suggest the presence of fear, anxiety and stigma in individuals with LTBI.This review highlights potential psychosocial challenges in individuals with LTBI despite the absence of clinical symptoms. While their quality of life was marginally affected, this could be evidence to support LTBI management in preventing TB re-activation and the severe consequences of active TB disease that affect all domains of HRQoL.

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“…HRQoL was assessed using the SF-36 questionnaire. Appropriate patient counselling with the help of Patient Information Lea let will help to improve the patient's quality of life and overall treatment outcome [6].…”

Section: Introductionmentioning

confidence: 99%

The role of clinical pharmacist in enhancing the health-related quality of life in patients with pulmonary tuberculosis

Varghese¹,

Poulose²,

G³

et al. 2020

ijrls

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Tuberculosis (TB) is potentially airborne severe infectious disease which requires long term treatment. It considerably affects the physical and mental health quality of the patient’s life. Appropriate patient counselling with the help of Patient Information Leaflet will help to improve the patient’s quality of life and overall treatment outcome. To enhance the health related quality of life in pulmonary tuberculosis patients by providing patient counselling with the aid of patient information leaflet. An interventional study was carried out for six months in 80 patients diagnosed with pulmonary tuberculosis from the OP & IP of Tuberculosis and Chest Department of a medical college hospital. The HRQoL was assessed using the SF-36 questionnaire. Appropriate patient counselling was provided with the help of Patient Information Leaflet. In our study, a total of 80 patients were enrolled, out of which 49[61%] were Out-patients, and 31[39%] were In-patients. All the 8 sub domains of the SF-36 survey show statistical significance with improvement in 2nd Visit (after counselling) when compared with the baseline visit. The demographic variables like smoking, low socioeconomic status, allergies, family history show statistically significant association with overall HRQoL. The HRQOL of the pulmonary tuberculosis patients were initially low before the start of Anti-TB therapy, after providing proper patient counselling using patient information leaflet the HRQoL scores were found to be increased on the subsequent re-visits, which implies the need of proper patient counselling and follow-up in PTB for the better quality of life.

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Health Status and Quality of Life in Tuberculosis: Systematic Review of Study Design, Instruments, Measuring Properties and Outcomes

Abstract: Background: Evaluation of patient reported outcome measures are important in improving the quality of life and effectiveness of care. Several measures have been developed to assess the health related quality of life of patients with tuberculosis.

Cited by 11 publications

References 37 publications

Quality of life with tuberculosis

Quality of life with tuberculosis

Impact of latent tuberculosis infection on health and wellbeing: a systematic review and meta-analysis

The role of clinical pharmacist in enhancing the health-related quality of life in patients with pulmonary tuberculosis

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