Despite decades of progress in the diagnosis, treatment, and prevention of cardiovascular disease, its prevalence continues to grow in both developed and developing countries. We have constructed a model, the "cycle of quality," which connects the innovation of initial scientific discovery with validated methods of translating research into effective delivery. This model can serve as a basis for evaluating proposed efforts to improve interactions among private and public aspects of health care to accelerate development and appropriate adoption of new treatments, and to achieve greater penetration of effective behavioral therapies and established technologies, resulting in major improvements in cardiovascular health. [Health Affairs 26, no. 1 (2007): 62-74; 10.1377/hlthaff.26.1.62] A m e r i c an s o c i e t y h a s w i t n e s s e d a remarkable convergence of effective diagnostic, preventive, and therapeutic approaches to cardiovascular disease (CVD). At the same time, the overall prevalence of CVD and its sequelae are rising as a result of the aging of the population in developed countries, greater longevity in developing countries, and the global epidemics of diabetes and obesity. A global view is especially important, because the greatest increase in prevalence and mortality will occur in countries with developing economies, and much effective CVD prevention and treatment does not require expensive technology, although technological advances have the potential to improve the health of patients with CVD on a global scale. J a n u a r y / F e b r u a r y 2 0 0 7 Q u a l i t y