Health risks of heavy metals in food and their economic burden in Armenia

Pipoyan, Davit; Stepanyan, Stella; Beglaryan, Meline; Stepanyan, Seda; Mendelsohn, Robert; Deziel, Nicole C.

doi:10.1016/j.envint.2023.107794

Cited by 16 publications

(5 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Pb is a widespread environmental contaminant and induces neurotoxicity. − There is a growing body of literature on the effects of Pb on anxiety and depression. It has been documented that early-life low-level Pb exposure alters anxiety-like behaviors in mice .…”

Section: Discussionmentioning

confidence: 99%

Chronic Pb Exposure Induces Anxiety and Depression-like Behaviors in Mice via Excitatory Neuronal Hyperexcitability in Ventral Hippocampal Dentate Gyrus

Zhou

Huang

et al. 2023

Environ. Sci. Technol.

View full text Add to dashboard Cite

Lead (Pb) is a widespread neurotoxic pollutant. Pb exposure is associated with mood disorders, with no well-established neural mechanisms elucidated. In the present study, we aimed to investigate whether excitatory neurons in the dentate gyrus subregion of the ventral hippocampus (vDG) played a key role in Pb-induced anxiety and depression-like behaviors. C57BL/6 mice were exposed to 100 ppm Pb starting on day 1 of pregnancy until experiments were performed using the offspring. Behavioral studies suggested that chronic Pb exposure triggered anxiety and depression-like behaviors. A combination of electrophysiological, optogenetic, and immunohistochemistry experiments was conducted. Results showed that Pb exposure resulted in excitatory neuronal hyperexcitability in vDG and that the behavioral deficits caused by Pb exposure could be rescued by inhibition of excitatory neuronal activity. Moreover, it was found that the action potential (AP) threshold of excitatory neurons was decreased by electrophysiological recordings. Our study demonstrates a significant role for excitatory neurons in vDG in Pb-induced anxiety and depression-like behaviors in mice, which is likely a result of decreased AP threshold. These outcomes can serve as an important basis for understanding mechanisms of anxiety and depression under environmental Pb exposure and help in the design of therapeutic strategies.

show abstract

Section: Discussionmentioning

confidence: 99%

Chronic Pb Exposure Induces Anxiety and Depression-like Behaviors in Mice via Excitatory Neuronal Hyperexcitability in Ventral Hippocampal Dentate Gyrus

Zhou

Huang

et al. 2023

Environ. Sci. Technol.

View full text Add to dashboard Cite

show abstract

“…The estimated daily intake (EDI) is calculated based on element levels and the amounts of mussels consumed. The following equation was used to calculate the EDI of heavy metals [31,32]:…”

Section: Estimated Daily Intake (Edi) and Estimated Weekly Intake (Ewi)mentioning

confidence: 99%

“…Food supply quantity (kg/capita/year) for category "Mollusks, Other" for Romania, period 2010 -2021, varied between 0.08 -0.50 kg/capita/year, respectively 0.00022 -0.00137 kg/day. Estimated weekly intake (EWI) were found by multiplying EDI values by 7 [31,32].…”

Section: Estimated Daily Intake (Edi) and Estimated Weekly Intake (Ewi)mentioning

confidence: 99%

“…Most PCBs show very high coefficients of variation, indicating significant variability in PCB concentrations across the fish samples. OCPs values exceeding the maximum admissible level for human consumption stipulated by national legislation (Order 147/2004) [32], were recorded mostly in mollusks (for HCB, Lindane, Dieldrin, Endrin, Heptachlor and Total DDT), but also in fish (for HCB, Dieldrin).…”

mentioning

confidence: 99%

See 1 more Smart Citation

From Waters to Fish: A Multi-Faceted Analysis of Contaminants Pollution Sources, Distribution Patterns, Ecological and Human Health Consequences

Damir,

Coatu,

Danilov

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…In some cases, they are introduced by mining. For example, in Armenia, more than 50% of daily lead intake exceeds the benchmark dose level of 0.63 µg/kg body weight/day set by the European Food Safety Agency (Pipoyan et al., 2023). It is worth noting that the levels of vegetable and food crop heavy metal contamination mainly depend on the mobility and bioavailability of heavy metals present in the soil (Islam et al., 2007).…”

Section: Research Progress In the Toxicological Assessment Of Hazards...mentioning

confidence: 99%

Zebrafish as model organisms for toxicological evaluations in the field of food science

Hou

Liu

Qin

et al. 2023

Comp Rev Food Sci Food Safe

View full text Add to dashboard Cite

Food safety has long been an area of concern. The selection of stable and efficient model organisms is particularly important for food toxicology studies. Zebrafish (Danio rerio) are small model vertebrates, and 70% of human genes have at least one zebrafish ortholog. Zebrafish have advantages as model organisms due to their short life cycle, strong reproductive ability, easy rearing, and low cost. Zebrafish embryos have the advantage of being sensitive to the breeding environment and thus have been used as biosensors. Zebrafish and their embryos have been widely used for food toxicology assessments. This review provides a systematic and comprehensive summary of food toxicology studies using zebrafish as model organisms. First, we briefly introduce the multidimensional mechanisms and structure–activity relationship studies of food toxicological assessment. Second, we categorize these studies according to eight types of hazards in foods, including mycotoxins, pesticides, antibiotics, heavy metals, endocrine disruptors, food additives, nanoparticles, and other food‐related ingredients. Finally, we list the applications of zebrafish in food toxicology studies in line with future research prospects, aiming to provide a valuable reference for researchers in the field of food science.

show abstract

Health risks of heavy metals in food and their economic burden in Armenia

Cited by 16 publications

References 32 publications

Chronic Pb Exposure Induces Anxiety and Depression-like Behaviors in Mice via Excitatory Neuronal Hyperexcitability in Ventral Hippocampal Dentate Gyrus

Chronic Pb Exposure Induces Anxiety and Depression-like Behaviors in Mice via Excitatory Neuronal Hyperexcitability in Ventral Hippocampal Dentate Gyrus

From Waters to Fish: A Multi-Faceted Analysis of Contaminants Pollution Sources, Distribution Patterns, Ecological and Human Health Consequences

Zebrafish as model organisms for toxicological evaluations in the field of food science

Contact Info

Product

Resources

About