Health-related quality of life in the Dialysis Outcomes and Practice Patterns Study (DOPPS)

Abstract

• Background: Health-related quality of life (HRQOL), a validated system of measuring patients' physical, mental, and social well-being, can be of particular use in populations with chronic conditions, such as end-stage renal disease (ESRD). Methods: The Dialysis Outcomes and Practice Patterns Study (DOPPS) has used the Kidney Disease Quality of Life Short Form (KDQOL-SF) to measure ESRD patients' self-assessment of functioning and well-being, as measured by 3 component scores: physical component summary (PCS, 4 subscales), mental component summary (4 subscales), and kidney disease component summary (11 subscales). Several DOPPS studies examined HRQOL's associations with mortality and hospitalization by country, ethnicity (United States only), and in comparison with serum albumin levels; international variations in HRQOL of ESRD patients were also evaluated. Results: Lower scores for all 3 summary scores were strongly associated with higher risk of death and hospitalization; these measures, especially PCS, may better identify patients at risk for death and hospitalization than serum albumin level. Japanese patients reported a greater burden of kidney disease but higher physical functioning than patients in Europe or the United States; many other significant regional differences in HRQOL were found. In the United States, all summary scores were significantly associated with mortality risk, regardless of ethnicity. Compared with whites, blacks had higher scores for all 3 summary scores, Asians and Hispanics had higher PCS scores, and Native Americans had lower mental component summary scores. Conclusion: Among ESRD patients, HRQOL displays an important predictive power for adverse events. Identifying effective interventions to improve the HRQOL of patients with ESRD should be viewed as a valued health care goal. Am J Kidney Dis 44(S2):S54-S60.

Assessment of Health-Related Quality of Life in Patients Receiving Regular Hemodialysis

“…Its score was relatively high (66.8 ± 23). The Dialysis Outcomes and Practice Patterns Study (DOPPS) study in 2004 noticed variation in sexual function scores worldwide with mean scores 66.7, 63.3 and 60.5 for Europe, Japan and USA respectively with statically significant difference between Europe and USA [15]. In the present study, the mean of HRQOL scores were relatively higher in younger age groups in all domains, yet there was no statistically significant difference.…”

“…Several studies proved that HD patients suffer poor HRQOL, despite continuing advancements in the treatment [3,4,[7][8][9][10][11][12][13][14]. Their HRQL is still much lower than general population [12,15]. Baseline measures of HRQOL were reduced in CKD patients in proportion to the severity grade of CKD [16].…”

Comparações de medidas de qualidade de vida entre mulheres e homens em hemodiálise

“…Além de informar sobre o impacto do tratamento no bem-estar dos pacientes, a avaliação da QVRS ajuda a identificar aqueles com risco maior de eventos adversos [2][3][4][5] . Os resultados de diversos estudos sugerem que, no curso de determinadas doenças, as mulheres são mais afetadas do que os homens na QVRS [6][7][8][9][10] .…”

Biomarkers and Health-Related Quality of Life in End-Stage Renal Disease

“…This is important because HRQOL remains a robust predictor of morbidity and mortality in ESRD and is an important surrogate of quality care (8,(11)(12)(13)(14). Thus, knowing which biomarkers optimally predict HRQOL may provide insight into how best to manage ESRD.…”

“…Because HRQOL is a consistent predictor of mortality in ESRD (8,(11)(12)(13)(14), there is interest in measuring HRQOL in both clinical trials and everyday clinical practice. This acknowledgment that the burden of ESRD extends beyond its impact on traditional biologic measures is reflected in initiatives from the National Kidney Foundation to support efforts aimed at improving HRQOL in patients with ESRD (5); however, many clinicians are not well versed in the interpretation of HRQOL, and HRQOL may fail to resonate with clinicians in the same way as traditional biomarkers such as dialysis adequacy indices, mineral metabolism markers, or anemia markers, among others.…”