Biomarkers and Health-Related Quality of Life in End-Stage Renal Disease

Spiegel, Brennan M.; Melmed, Gil Y.; Robbins, Sean; Esrailian, Eric

doi:10.2215/cjn.00820208

Cited by 112 publications

(102 citation statements)

References 83 publications

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“…Spiegel et al [15] documented highly significant independent correlations between dry weight and both PCS and MCS scores of the SF-36, similar to results of our study. Also, Kalantar-Zadeh et al [16] documented highly significant independent correlations between BMI and both PCS and MCS scores of the SF-36, which was in agreement with our study.…”

Section: Discussionsupporting

confidence: 92%

“…In our study, there was no significant relation between dialysis adequacy, as measured by Kt/V and QOL. Our findings were similar to the findings of Fabrizi et al [8] and Spiegel et al [15]. In contrast, Asfar et al [4] found that Kt/V was only correlated with the mental health subscale.…”

Section: Discussionsupporting

confidence: 92%

“…Similarly, Fabrizi et al [8] reported direct relationship between serum creatinine and SF-36 scale scores in hemodialysis population and the largest correlations were recorded in the general health, mental health, and bodily pain subscales. Also, Spiegel et al [15] found that patients with low creatinine had a significantly lower adjusted SF-36 PCS score versus patients with higher levels of serum creatinine. In our study, there was no significant relation between dialysis adequacy, as measured by Kt/V and QOL.…”

Section: Discussionmentioning

confidence: 99%

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Quality of Life in Hepatitis C Virus Seropositive Hemodialysis Patients

Ezzat¹

2015

UNOAJ

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Background: Health-related quality of life (HRQOL) is a multidimensional concept that reflects a patient's perceived well-being. It was well demonstrated that HCV had a negative impact on (HRQOL). The aim of this study was to assess HRQOL in hepatitis C Virus (HCV) seropositive hemodialysis Egyptian patients and highlight possible factors affecting it.Patients and methods: : 200 ESRD patients on regular hemodialysis at Ain Shams University hospitals and National Institute of Nephrology and Urology were included in this study and divided into 2 equal groups of HCV Ab seronegative and seropositive. Both groups were subjected to full medical history taking and examination. Laboratory investigations included hemoglobin level, pre dialysis blood urea, creatinine, calcium, phosphorus, PTH, ALT, AST, albumin and viral markers. Dialysis adequacy using Kt/v. HRQOL was measured through Short Form 36 (SF-36). In each dimension the respondent receives a score from 0 to 100. The higher the score, the better the health.Results: Our study showed that HCV seropositive hemodialysis patients had compromised HRQOL in comparison to HCV seronegative patients which was found in most of SF-36 subscales with higher scores for employed patients compared to the unemployed and those with higher haemoglobin levels. High pre dialysis serum creatinine, dry weight and serum albumin had significant positive correlation with SF-36 scale scores. Elevated liver enzymes and dialysis adequacy had no significant correlation with SF-36 scale scores. A significant negative correlation was present between serum phosphate and PTH on overall HRQOL. Conclusion:HCV infection impairs HRQOL, in many aspects in hemodialysis patients. Better HRQOL is associated with male gender, younger age, employment, higher hemoglobin, higher pre dialysis serum creatinine and higher serum albumin. Prevention of HCV transmission by proper infection control measures reduces the economic burden and complications in hemodialysis. Keywords: IntroductionHealth-related quality of life (HRQOL) is a multidimensional concept that reflects a patient's perceived well-being and functioning in physical, psychological and social domains of health [1]. End-stage renal disease (ESRD) is a chronic restrictive illness that affects many aspects of patient's life. Moreover, ESRD has become worldwide public health problem [2] causing a high level of disability in different domains of the patients' lives, leading to impaired quality of life (QoL) [3]. Although there have been many advances in the treatment of end-stage renal disease (ESRD), mortality rates for ESRD patients remain several times higher than those of age-matched controls, and patients with ESRD continue to have significant impairments in quality of life (QOL), quality of life is related with morbidity and mortality in hemodialysis patients, and it is suggested that QOL should be considered in the regular monitoring of dialysis patients [4]. Hemodialysis patients infected with HCV often have poor shortterm clinical outcome,...

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

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Quality of Life in Hepatitis C Virus Seropositive Hemodialysis Patients

Ezzat¹

2015

UNOAJ

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“…Multiple confounding factors previously reported to be associated with mental health and outcomes in the general population and dialysis patients were considered as covariates (27)(28)(29). Demographic and clinical factors included in the analysis were age, sex, race, education, marital status, history of cardiovascular disease (CVD), history of coronary artery disease (CAD), body mass index, blood pressure, smoking status, comorbidities (including ICED scores and diabetic status), dialysis vintage, treatment arms, sleep quality, and medication use.…”

Section: Covariate Selectionmentioning

confidence: 99%

The Association of Mental Health over Time with Cardiac Outcomes in HEMO Study Patients

Kang

Pike

Ramer

et al. 2012

Clinical Journal of the American Society of Nephrology

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Summary Background and objectives Poor mental health over time is significantly associated with cardiovascular morbidity and mortality in the general population, which is the leading cause of death in dialysis patients. Most studies of dialysis patients, however, have investigated the relationship between baseline mental health measurements and all-cause mortality and not mental health measured longitudinally throughout a study and cause-specific mortality. Design, setting, participants, & measurements This study examined the association of changes in mental health over time with all-cause and cause-specific deaths and cardiac hospitalizations in the Hemodialysis study patients. Mental health was assessed at baseline and annually during the study with short form 36 mental health index scores. Poorer mental health was defined by a mental health index score≤60. Results Patients with poorer mental health at baseline were more likely to have less than a high school education and be unmarried, have significantly higher index of coexistent disease scores, and report taking β-blockers and sleep medications. Low mental health scores over time were independently associated with a decrease in survival time from all-cause mortality by −0.06 (−0.10, −0.03; P<0.001), and they also significantly hastened time to first cardiac hospitalization by −0.08 (−0.13, −0.02; P=0.01) and composite of first cardiac hospitalization or cardiac death by −0.04 (−0.07, −0.02; P<0.001). Conclusions This study found an independent association between poor mental health over time and all-cause mortality, cardiac hospitalization, and the composite of cardiac death or cardiac hospitalization in hemodialysis patients. The results underscore the importance of attention to mental health related to cardiac complications and even death in dialysis patients.

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“…In addition, patients on hemodialysis, with little prospect of no longer requiring treatment, increase the cost of health systems, and their quality of life markedly reduces. Thus, it is becoming increasingly necessary to organize and facilitate patient access to services 13,14,15,16 .…”

Section: Introductionmentioning

confidence: 99%