Health-Related Quality of Life in Long-Term Survivors After Heart and Lung Transplantation: A Prospective Cohort Study

Abstract

HTx and LTx patients benefit from the transplant procedure with respect to HRQoL improvements for at least 5 years posttransplant; however, their trajectories during this time interval differ. Further research on organ-type-related predictors of HRQoL is necessary for the development of tailored psychosocial interventions.

Patient-reported health outcomes in long-term lung transplantation survivors: A prospective cohort study

“…These chronic diseases considerably reduce the patients’ HRQoL. Previous studies have shown that the most noteworthy improvements in HRQoL happen during the first year after transplantation 11, 12. In our study, we also found that most improvement occurred within the first year in the main domains of HRQoL (psychological, social, and physical) except for the pain domain of NHP, which stayed constant during the whole study period.…”

“…However, the generalizability of these studies is constrained by methodological problems such as cross‐sectional design, short‐term follow‐up, and small sample sizes. A few longitudinal studies have evaluated HRQoL after lung transplantation 11, 12, 13, 14. The biggest changes they report occur in the early posttransplantation period in the domains of physical health and functioning, like walking capacity, which generally remained constant in subsequent follow‐ups.…”

Impact of Lung Transplantation on Recipient Quality of Life

“…30 We acknowledge that the generalizability of our results is limited to lung transplant recipients with similar characteristics as trial participants. 23 consistent with previous QOL studies in lung transplantation 4,[6][7][8][9][10][11][12][13][14][15][16][17]22 and are likely refl ective of the documented dramatic improvements in FEV 1 and blood arterial oxygenation after transplant. 3,[18][19][20] Our results, thus, confi rm these previous reports in the context of a larger multicenter cohort and extend them by providing insight into the trajectory of QOL improvements over the fi rst year posttransplant.…”

“…Similar challenges confound the few studies that have examined QOL longitudinally after lung transplantation. [17][18][19][20][21][22] Therefore, despite the important observations made in previous studies, additional multicenter, prospective efforts are needed to assess the true impact of lung transplantation on an individual's physical, social, and emotional functioning.…”

Dynamic of Physical Capacity and Quality of Life After Heart Transplantation

“…По данным различных исследований, после ТС качество жизни (КЖ) реципиентов улучшается как в сфере физического, так и психологического благополучия и остается стабильно высоким [6][7][8][9]. Однако несмотря на субъективное улучшение самочувствия, уровень физической работоспособ-ности (ФР) у части пациентов после ТС не соот-ветствует возрастной норме здорового человека, а восстановление переносимости физических на-грузок (ФН), определяемое по пиковому потребле-нию кислорода (VO 2peak ), достигает только 50-70% от должных значений для данного пола и возрас-та.…”