Health‐related quality of life in hypothyroidism—A population‐based study, the WHO MONICA Project

Ellegård, Lotta; Krantz, Emily; Trimpou, Penelope; Landin‐Wilhelmsen, Kerstin

doi:10.1111/cen.14448

Cited by 12 publications

(4 citation statements)

References 26 publications

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“…The number of our patients is not higher can be accepted as a limitation. Although some authors reported that the effects of hypothyroidism on quality of life were different in male and female patients (34), some authors stated that the gender factor was ineffective (35). We included only female patients in order to avoid suspicion of bias.…”

Section: Discussionmentioning

confidence: 99%

The effect of thyroid hormone withdrawal performed to evaluate the success of I-131 ablation on quality of life and psychological symptoms in female patients with low-risk differentiated thyroid cancer

Kupik

Şen

Arpa

et al. 2023

Journal of Health Sciences and Medicine

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Aim: There is a need to evaluate the treatment response in patients who have undergone radioiodine treatment (RIT) for differentiated thyroid cancer. Diagnostic tests that are used for this purpose include radioiodine whole-body scan (WBS) and serum thyroglobulin (Tg) measurement, which are most accurate during thyroid-stimulating hormone (TSH) stimulation. However, temporary discontinuation of thyroid hormone therapy to increase TSH (withdrawal) may be associated with the morbidity of hypothyroidism. The study aimed to show the effects of thyroid hormone withdrawal (THW) on quality of life and psychological symptoms in female patients with low-risk, well-differentiated papillary thyroid cancer. Methods: We applied the short form-36 (SF-36) and Symptom Checklist-90-R (SCL-90-R) questionnaires to the patients in the euthyroid state who have referred a median of 9 months (6-13 months) after RIT to perform a dWBS and to evaluate stimulated Tg. We applied the same questionnaire again when thyroid-stimulating hormone (TSH) was > 30 μIU/mL 4 weeks after THW (hypothyroid state). Results: 52 patients were evaluated (median age 48 years, range 23-65 years). There was a statistically significant worsening in anxiety, psychosis, additional items, and general symptoms of the SCL-90-R questionnaire, physical functioning, role limitation due to physical health, energy/fatigue, emotional well-being, social function, and general health change in the SF-36 questionnaire. Conclusions: THW worsened the patients’ psychological symptoms and quality of life. To reduce the side effects of hypothyroidism, treatment response assessment with TSH stimulation should be used only in a selected group of patients with a higher risk of recurrence.

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Section: Discussionmentioning

confidence: 99%

The effect of thyroid hormone withdrawal performed to evaluate the success of I-131 ablation on quality of life and psychological symptoms in female patients with low-risk differentiated thyroid cancer

Kupik

Şen

Arpa

et al. 2023

Journal of Health Sciences and Medicine

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“…Although there is an association between hypothyroidism and obesity [38], there is still a lack of evidence to explain the high prevalence of the former among women with lipoedema [32]. Because hypothyroidism, like lipoedema, may cause health issues such as fatigue, weight gain, feeling cold, and sleep problems [39] we recommend health care professionals to bring attention to, and to evaluate thyroid function among women with lipoedema. Furthermore, over 17% of participants in this study reported having fibromyalgia, which is a higher prevalence than reported in females in the general populations that ranges from 2.4 to 6.8% [40].…”

Section: Discussionmentioning

confidence: 99%

Women with lipoedema: a national survey on their health, health-related quality of life, and sense of coherence

et al. 2022

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Background Lipoedema is a chronic disease in adipose tissue that almost exclusively affects women during periods of hormonal alterations. Its main symptoms include an abnormal accumulation of subcutaneous fat in the buttock, hips, and legs, which is associated with pain, swelling, and easy bruising. Herein, a grading in three stages is used to determine disease progression. Problematically, lipoedema manifestations are often confused with lifestyle-induced obesity, which is why the various health problems among affected women often remain unrecognized. Overall, research on lipoedema is scarce. As such, this study examined the health, health-related quality of life (HRQOL), and sense of coherence (SOC) among women with lipoedema. Methods We conducted a national cross-sectional study using an online survey assessing sociodemographic data, lipoedema characteristics, symptom severity, comorbidities, HRQOL (RAND-36), and SOC (SOC-13). In total, 245 women with lipoedema, recruited from all Lipoedema Association groups in Sweden, participated. Data were compiled with descriptive statistics, and mean differences between groups were analysed by using parametric and non-parametric tests. Results Moderate and severe leg heaviness, pain, numbness, cold skin, feeling cold, easy bruising, and sleep problems were found to occur in all lipoedema stages. Moreover, almost all participants reported having comorbidities. Worse physical health and most substantial limitations in daily life were reported among women with the most progressive lipoedema (i.e., stage 3). Social and emotional functioning and SOC were found to be, on the other hand, primarily related to respondents’ sociodemographic data and their ages at lipoedema onset. Even though approximately 70% of the women had experienced lipoedema onset before age 30, only three (1.6%) had been diagnosed by a healthcare professional before that age. Conclusion Having lipoedema is associated with several health problems and a lower HRQOL. In addition, the extent of delay in diagnosis within this sample indicates that many women with lipoedema are often underdiagnosed and are left without support from healthcare. These findings call for the need for greater attention on lipoedema. Moreover, further studies on how women with lipoedema manage their health and symptoms, as well as on their experiences of healthcare services and lipoedema treatments, are needed.

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“…Since thyroid hormones are essential for normal growth and energy metabolism, thyroid dysfunction can have profound adverse consequences [ 4 ]. Despite the increased awareness and the improvements in medical management of this disease, depression, mood disturbance and poor health-related quality of life (QoL) is pretty common among hypothyroid patients [ 5 , 6 ]. Hypothyroid patients also have reported to have higher blood pressure than their euthyroid counterparts [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

The effect of synbiotic supplementation on hypothyroidism: A randomized double-blind placebo controlled clinical trial

2023

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Objective We hypothesize that synbiotic supplementation could modulate the intestinal microbiota and subsequently, improve the condition of hypothyroid patients. Methods Fifty-six adult hypothyroid patients were recruited to this double-blind, placebo-controlled, randomized clinical trial. The intervention was 10 weeks of synbiotic (500 mg of 109 CFU/g probiotics plus fructo-oligosaccharide, n = 28) compared to placebo (lactose, magnesium stearate, talc, and silicon dioxide, n = 28). Randomization and allocation to trial groups were carried out using random number sequences drawn from https://sealedenvelope.com/. Primary outcomes were serum thyroid stimulating hormone (TSH) and free thyroxine (FT4), and secondary outcomes were depression, quality of life, and blood pressure (BP). P-values< 0.05 were considered statistically significant. Results Analysis on 51 patients who completed the trial showed that TSH and depression (p> 0.05) did not change significantly, while serum FT4 significantly increased in both groups (p = 0.03 and p = 0.02 in symbiotic and placebo respectively). A significant decrease in systolic BP occurred only in the synbiotic group (p = 0.05). Significant improvements occurred regarding different domains and areas of quality of life in the crude and adjusted analysis, including perceived mental health (p = 0.02), bodily pain (p = 0.02), general health perception (p = 0.002), and wellbeing (p = 0.002), which were significantly higher in the synbiotic group. Conclusions Ten-week supplementation with synbiotic had no favorable effect on depression and TSH, but it improved blood pressure and quality of life in patients with hypothyroidism. More trials are needed to support or reject these findings. Trial registration IRCT20210926052583N1, Iranian Registry of Clinical Trials (IRCT), registered October 1st, 2021.

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Health‐related quality of life in hypothyroidism—A population‐based study, the WHO MONICA Project

Cited by 12 publications

References 26 publications

The effect of thyroid hormone withdrawal performed to evaluate the success of I-131 ablation on quality of life and psychological symptoms in female patients with low-risk differentiated thyroid cancer

The effect of thyroid hormone withdrawal performed to evaluate the success of I-131 ablation on quality of life and psychological symptoms in female patients with low-risk differentiated thyroid cancer

Women with lipoedema: a national survey on their health, health-related quality of life, and sense of coherence

The effect of synbiotic supplementation on hypothyroidism: A randomized double-blind placebo controlled clinical trial

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