Health-Related Quality of Life in Oral Cancer: A Review

Chandu, Arun; Smith, Andrew C.; Rogers, Simon N.

doi:10.1016/j.joms.2005.11.028

Cited by 221 publications

(138 citation statements)

References 72 publications

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“…The OCSCC is a multifactorial condition with etiological links to a wide range of external carcinogens, including alcohol, tobacco, betel nut, and to certain viral and bacterial infections (Lo et al, 2003). Although OCSCC is a potentially curable disease in its early stages, its treatment is associated with a plethora of long-term side effects, post-therapeutic complications and a significant decrease in the quality of life (Chandu et al, 2006). Typically, 50% OCSCC patients have a detectable lymph node involvement at presentation.…”

Section: Introductionmentioning

confidence: 99%

Expression of FLJ10540 is correlated with aggressiveness of oral cavity squamous cell carcinoma by stimulating cell migration and invasion through increased FOXM1 and MMP-2 activity

Chien

et al. 2009

Oncogene

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Matrix metalloproteinase (MMP)-2 plays critical roles in tumor development and in the metastasis of multiple cancers, including human oral cavity squamous cell carcinoma (OCSCC). One of the upstream regulators of MMP-2 is FOXM1, which is overexpressed in a microarray dataset of OCSCC. It is interesting that FLJ10540 exhibits similar gene expression profiles with MMP-2 and FOXM1, raising the possibility that these molecules might participate in MMP-2-elicited cancer progression and metastasis of OCSCC. To examine this connection, we first showed that FLJ10540 was significantly overexpressed in OCSCC. A strong FLJ10540 expression was significantly correlated with an advanced tumor node metastasis stage and the cumulative 5-year survival rate. Thus, an elevated FLJ10540 expression is an indicator of poor survival. Functionally, FLJ10540 had the abilities to stimulate cell migration and invasion in oral cancer cells through increased FOXM1 and MMP-2 expressions. Conversely, the depletion of the FLJ10540 expression by small interefering RNAs suppressed the FOXM1 and MMP-2 protein expressions. The suppression of either FLJ10540 or FOXM1 could cause significant inhibition on cell migratory and invasive ability in oral cancer cells. Finally, the immunohistochemical and western blotting analyses of human aggressive OCSCC specimens showed a significant positive correlation among FLJ10540, FOXM1 and MMP-2 expressions. These findings suggest that FLJ10540 is not only an important prognostic factor but also a new therapeutic target in the FLJ10540/FOXM1/MMP-2 pathway for OCSCC treatment.

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Section: Introductionmentioning

confidence: 99%

Expression of FLJ10540 is correlated with aggressiveness of oral cavity squamous cell carcinoma by stimulating cell migration and invasion through increased FOXM1 and MMP-2 activity

Chien

et al. 2009

Oncogene

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“…26 Studies assessing the psychological status of oral cancer patients indicate that the depressive symptoms impact of the disease and its treatment are substantial and that is estimated to have prevalence from 22% to 32% in oral cancer survivors including loss of energy and hopefulness, appetite changes, sleep disturbances, fatigue, facial disfigurement and isolation. [27][28][29] Failure to identify and deal with depression generally reduces the quality of life. 30 Here, in this study, 69% said that they do not need any psychological counseling.…”

Section: Discussionmentioning

confidence: 99%

Evaluating the epidemiology and needs of oral cancer patients from Aurangabad district, Maharashtra, India

Niranjan¹,

Ranpise

2017

Int J Res Med Sci

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Background: India is facing burden of non-communicable diseases and oral cancer is one of the leading public health issue. This is a descriptive study from Aurangabad district, Maharashtra, India to evaluate epidemiologic profile of oral cancer patients who underwent treatment during 2012 to 2016.Methods: Demographic and clinical profile of 500 patients was recorded with validated questionnaire.Results: With male: female ratio was 2.90:1; the mean age of the patients of oral cancer was 47.73 years. Tobacco consumption was the leading cause associated with statistically significant association (p value < 0.000) among the gender and tobacco use suggesting men are more prone to use tobacco than women. 74% patients received satisfactory treatment and all the patients strongly reported need of doctor’s advice, family support, discontinuation of substance abuse habits and financial help. Patients reported the need of acceptance by society and good diet and nutrition. However, many denied the need of psychological counseling and regular check-up. There was statistically significant association (p value < 0.001) found among the gender and needs for good diet and nutrition, psychological counseling, regular check-up, discontinuation of tobacco habits. Statistically significant association (p value < 0.001) found among the occupation and needs for good diet and nutrition, psychological counseling and acceptance by society.Conclusions: The study projects the epidemiology and focuses on the needs of the patients which require the specific attention and efforts through patient’s education and awareness.

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“…Mandibular defects are the most common oral and maxillofacial defects [2]. Mandibular defects not only destroy the appearance of patients but also affect facial functions [3].…”

Section: Introductionmentioning

confidence: 99%

An integrated system for planning, navigation and robotic assistance for mandible reconstruction surgery

Kong

Duan

Wang

2015

Intel Serv Robotics

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Mandibular reconstruction is an extremely complex and high-risk surgery. The aim of the study was to integrate robotics technology into mandibular reconstruction surgery as it can reduce surgeons' workload and improve the accuracy and quality of the surgery. In this study, we first introduced a mandibular reconstruction surgery robotic system, which includes integrated surgery planning, an optical navigation system, and a robot-assisted operation. Second, we addressed novel mandibular reconstruction surgery that is aided by a multi-arm robot with an optical navigation system. Finally, we conducted an accuracy test, a skull model experiment, and an animal experiment to evaluate the robotic system. Experiments showed that the robot's mean placement error was 1.0205 mm, which was acceptable for clinical application. We will continue to study this point, however, and plan to reduce the error eventually to 1.00 mm. The robot ran smoothly and accurately. It was also able to perform fibular segment implantation, positioning, and auxiliary fixation during mandibular reconstruction surgery.

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Health-Related Quality of Life in Oral Cancer: A Review

Cited by 221 publications

References 72 publications

Expression of FLJ10540 is correlated with aggressiveness of oral cavity squamous cell carcinoma by stimulating cell migration and invasion through increased FOXM1 and MMP-2 activity

Expression of FLJ10540 is correlated with aggressiveness of oral cavity squamous cell carcinoma by stimulating cell migration and invasion through increased FOXM1 and MMP-2 activity

Evaluating the epidemiology and needs of oral cancer patients from Aurangabad district, Maharashtra, India

An integrated system for planning, navigation and robotic assistance for mandible reconstruction surgery

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