Evaluating the epidemiology and needs of oral cancer patients from Aurangabad district, Maharashtra, India

Abstract

Background: India is facing burden of non-communicable diseases and oral cancer is one of the leading public health issue. This is a descriptive study from Aurangabad district, Maharashtra, India to evaluate epidemiologic profile of oral cancer patients who underwent treatment during 2012 to 2016.Methods: Demographic and clinical profile of 500 patients was recorded with validated questionnaire.Results: With male: female ratio was 2.90:1; the mean age of the patients of oral cancer was 47.73 years. Tobacco consumption was the leading cause associated with statistically significant association (p value < 0.000) among the gender and tobacco use suggesting men are more prone to use tobacco than women. 74% patients received satisfactory treatment and all the patients strongly reported need of doctor’s advice, family support, discontinuation of substance abuse habits and financial help. Patients reported the need of acceptance by society and good diet and nutrition. However, many denied the need of psychological counseling and regular check-up. There was statistically significant association (p value < 0.001) found among the gender and needs for good diet and nutrition, psychological counseling, regular check-up, discontinuation of tobacco habits. Statistically significant association (p value < 0.001) found among the occupation and needs for good diet and nutrition, psychological counseling and acceptance by society.Conclusions: The study projects the epidemiology and focuses on the needs of the patients which require the specific attention and efforts through patient’s education and awareness.

In silico analyses of the human sperm‐specific antigen 2 and its role in oral squamous cell carcinoma

“…From various epidemiological studies, it has been shown that tobacco (smokeless or smokeable) is the main cause of oral cancer incidences worldwide [144–150]. Tobacco contains carcinogens, radioactive elements, and heavy‐metal ions capable of inducing cellular damage and genetic mutations in the oral mucosa [151–157].…”

“…Thus, SSFA2 isoforms are potentially suitable for interactions with a diverse array of molecular partners (proteins, RNA, and/or DNA) and regulating multiple molecular pathways [142]. The TDSs of SSFA2 isoforms designed using RaptorX were validated From various epidemiological studies, it has been shown that tobacco (smokeless or smokeable) is the main cause of oral cancer incidences worldwide [144][145][146][147][148][149][150]. Tobacco contains carcinogens, radioactive elements, and heavy-metal ions capable of inducing cellular damage and genetic mutations in the oral mucosa [151][152][153][154][155][156][157].…”

Relationship between Thickness of Early Oral Tongue Carcinoma (T1, T2) with Cervical Lymph Node Metastasis

“…Carcinoma of oral tongue is the most common oral cancer in the world with a reported incidence of 17.8-52% and the second commonest cancer of oral cavity in India 1 . Tongue, because of its structure and function is prone for early local and regional spread of cancer.…”