Health-Related Quality of Life in Childhood Cancer

Fakhry, Hala; Goldenberg, Matthew; Sayer, Gregory; Aye, San San; Bagot, Kara; Pi, Sarah; Ghazzaoui, Rassil; Vo, Ngoctram; Gowrinathan, Shanthi; Bolton, Michael; IsHak, Waguih William

doi:10.1097/dbp.0b013e31828c5fa6

Cited by 38 publications

(31 citation statements)

References 47 publications

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“…This may hamper the correct identification of patients with important cancer‐related fatigue. The somewhat conflicting results between the self‐reports and the parent‐proxies that were found in this study, is a phenomenon that is often encountered in pediatric psychosocial research . There is often lower agreement on subjective outcomes, such as cancer‐related fatigue, compared with more objective outcomes .…”

Section: Discussionmentioning

confidence: 99%

Longitudinal development of cancer‐related fatigue and physical activity in childhood cancer patients

Dijk-Lokkart

Steur

Braam

et al. 2019

Pediatric Blood & Cancer

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Purpose Cancer‐related fatigue is one of the most distressing side effects of childhood cancer treatment. Physical activity can decrease fatigue and has positive effects on other health outcomes. Most research on physical activity pertains to adults, and the few studies that focus on children have limited follow‐up time. This study evaluates cancer‐related fatigue in children and its association with physical activity over a one‐year time period. Methods Sixty‐eight children with cancer (7–18 years) were recruited during or within the first year after treatment. Physical activity (Actical activity monitor) and cancer‐related fatigue (Pediatric Quality‐of‐Life Questionnaire Multidimensional Fatigue Scale (PedsQL‐MFS), self‐ and parent‐ reports) were assessed at baseline, 4 months, and 12 months. PedsQL‐MFS scores were compared with Dutch norms. Longitudinal association of cancer‐related fatigue with physical activity was evaluated (No. NTR 1531). Results Generally, PedsQL‐MFS scores were worse than norms at baseline and 4 months, and recovered by 12 months except for the parent‐proxy scores in adolescents. Younger children (≤12 years) self‐reported comparable or better scores than norms. Physical activity generally improved over time, but patients mostly remained sedentary. During follow‐up, increased physical activity was associated with less cancer‐related fatigue. Conclusion Cancer‐related fatigue in children improves over time, and increased physical activity is associated with less cancer‐related fatigue. Given the sedentary lifestyle of this population, the positive effect of physical activity on cancer‐related fatigue, and the many other health benefits of an active lifestyle, it is important to stimulate physical activity in childhood cancer patients and survivors.

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Section: Discussionmentioning

confidence: 99%

Longitudinal development of cancer‐related fatigue and physical activity in childhood cancer patients

Dijk-Lokkart

Steur

Braam

et al. 2019

Pediatric Blood & Cancer

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“…[3][4][5][6][7] Patient symptoms often go undetected during typical clinic interviews, and clinicians may underestimate the impact of symptoms from interview alone. [8][9][10] The impact of cancer and cancer treatment on patient health status can be systematically quantified using PRO measures in children and adults.…”

Section: Pros Systematically Quantify Patient Experiencesmentioning

confidence: 99%

“…[8][9][10] The impact of cancer and cancer treatment on patient health status can be systematically quantified using PRO measures in children and adults. 5,11,12 Use of PROs in these populations has identified symptoms and impairments in patient function. Most patients receiving treatment experience decreased health status 13,14 ; however, cancer patients with better symptom management and better PROs live longer with less distress.…”

Section: Pros Systematically Quantify Patient Experiencesmentioning

confidence: 99%

Patient-reported outcomes in clinical practice

Dobrozsi

Panepinto

2015

Hematology

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“…In this review the distress was different in different phases of the illness; for example the wellbeing increased over time, but it often took a long time. Fakhre et al [37] carried out a literature review on quality of life from diagnosis to remission/survivorship and end of life for children with cancer. They found that those who are newly diagnosed with cancer and undergo treatment, or are terminally ill, have impaired health-related quality of life (HRQoL).…”

Section: Discussionmentioning

confidence: 99%

A literature Review of the Results from Nursing and Psychosocial Research within Swedish Pediatric Oncology

Enskär

Knutsson²,

Huus³

et al. 2013

J Nurs Care

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A literature review of the results from nursing and psychosocial research within Swedish pediatric oncology. Nursing & Care, 3(6) Journal of AbstractThe body of research-based knowledge in paediatric caring science has been increasing leading to dramatic improvements in treatment. The purpose of this manuscript was to analyze results as stated by the researchers', in recently published articles on nursing and psychosocial research, within Swedish pediatric oncology setting. This was done through a review of 137 published articles about paediatric oncology related to caring science in Sweden. The result shows that the illness has affected, in both positive and negative ways, the wellbeing of everyone coming into contact with the child. The cancer also causes distress related to all aspects of life including physical, psychological, existential and social. Mediating factors for the experience of distress and wellbeing are: disease and treatment severity, age, gender and ethnicity of the participant, time since diagnosis, the use of internal and external support, and the identity of the person reporting the data. Health promoting aspects frequently reported are: family togetherness, coping strategies, engaging in normal life and activities, and quality of care which includes emotional support, information and family participation in care. The hospital staff has to be aware of the psychosocial issues experienced by children with cancer and their families, and they have to acknowledge the value of formal interventions, reporting benefits for children, families, and themselves.

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Health-Related Quality of Life in Childhood Cancer

Cited by 38 publications

References 47 publications

Longitudinal development of cancer‐related fatigue and physical activity in childhood cancer patients

Longitudinal development of cancer‐related fatigue and physical activity in childhood cancer patients

Patient-reported outcomes in clinical practice

A literature Review of the Results from Nursing and Psychosocial Research within Swedish Pediatric Oncology

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