Health-related quality of life assessment in Indonesian childhood acute lymphoblastic leukemia

Sitaresmi, Mei Neni; Mostert, Saskia; Gundy, Chad M.; Sutaryo, Sutaryo; Veerman, A. J. P.

doi:10.1186/1477-7525-6-96

Cited by 78 publications

(123 citation statements)

References 27 publications

(34 reference statements)

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“…A second study conducted in the developing country of Indonesia also had similar findings. 21 Our study described guardian-reported QoL as assessed using the PedsQL 4.0 Generic Core Scales and 3.0 Cancer Modules in 98 patients with ALL.…”

Section: Discussionmentioning

confidence: 99%

Quality of life during active treatment for pediatric acute lymphoblastic leukemia

Sung

Yanofsky

Klaassen

et al. 2010

Intl Journal of Cancer

121

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The objectives of the study were to describe quality of life (QoL), identify predictors of worse QoL and examine QoL during different phases of active therapy for acute lymphoblastic leukemia (ALL). A multiinstitutional cross-sectional study was performed in children with ALL. We included children at least 2 months from diagnosis who were receiving treatment in first remission. Parents described QoL using the PedsQL 4.0 Generic Core Scales and the PedsQL 3.0 Acute Cancer Module. The 206 children on treatment for ALL had overall [median 62.5, 95% confidence interval (CI) 34.8-94.4], physical (median 62.5, 95% CI 18.8-100.0) and psychosocial (median 65.4,2) summary scores that were one to two standard deviations lower than population norms. In high-risk ALL, girls and older children had worse QoL. In standard-risk ALL, those with lower household incomes and unmarried parents had worse QoL. QoL scores were generally constant across phases of ALL therapy. Children on therapy for ALL have lower QoL compared to healthy children. Age and gender predicted QoL in highrisk ALL, whereas socioeconomics predicted QoL in standard-risk ALL. Future efforts should focus on longitudinal studies that describe QoL over time within individual patients.Acute lymphoblastic leukemia (ALL) is the most common cancer in children. Outcomes for children with ALL have continued to improve over time, and currently, almost 80% of children are cured of their disease with primarily outpatient chemotherapy. 1 Because cure rates have increased, more emphasis has been placed on reducing toxicities of therapy, improving quality of life (QoL) during treatment and minimizing long-term effects of therapy. Contemporary chemotherapy regimens for childhood leukemia are lengthy with medications administered over 2.5-3.5 years, and thus, more attention has been directed at understanding QoL during active therapy.To date, published QoL research in pediatric cancer has mainly focused on diverse patient groups, which is appropriate for early exploratory work in describing QoL and validating instruments. However, as our knowledge of QoL in pediatric cancer progresses, it is important to begin to focus on specific subpopulations. Most likely, pediatric cancer patients with differing diagnoses and treatments have different levels and determinants of QoL.Two systematic reviews have examined measurement of QoL for children with ALL. 2,3 Most research has focused on survivorship and much less on the period during active treatment. 2 Of those studies that have included children during active treatment, sample sizes for ALL patients have been small and, in general, have not been designed to identify those more likely to have worse QoL on therapy or to compare QoL during different phases of treatment.Thus, research focused on children with ALL during active treatment is important and remains an area in which we lack knowledge about predictors of QoL and changes in QoL over different phases of therapy. Consequently, our objectives were to describe QoL in a large cohort ...

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Section: Discussionmentioning

confidence: 99%

Quality of life during active treatment for pediatric acute lymphoblastic leukemia

Sung

Yanofsky

Klaassen

et al. 2010

Intl Journal of Cancer

121

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“…Furthermore, other studies have shown that educational interventions have an impact on the quality of life of children with other chronic diseases such as asthma, cardiovascular, and so on. 12 Hashemi et al showed that before the intervention quality of life scores in experimental and control groups were 180.83 ± 14.43 and 174.28 ± 20.72 and after the intervention be 226.9 ± 11.76 and 174.41 ± 20.42. 12 Results showed that quality of life improved significantly in the experimental group.…”

mentioning

confidence: 99%

“…12 Hashemi et al showed that before the intervention quality of life scores in experimental and control groups were 180.83 ± 14.43 and 174.28 ± 20.72 and after the intervention be 226.9 ± 11.76 and 174.41 ± 20.42. 12 Results showed that quality of life improved significantly in the experimental group. These results together with Cetinkaya and Kurt which indicates that the quality of life of children leukemia after providing information increased significantly compared with before giving the information.…”

mentioning

confidence: 99%

“…10 Several studies have also reported that an increase in parental knowledge about the problems and needs of children with leukemia have an important effect on family support so that parents can provide optimal care which leads to a significant improvement in the quality of life of children. 11,12 Malone (2007) outlines the information given on educational intervention in the form of the side effects of chemotherapy agents include disorders blood counts, nausea, vomiting, fatigue, diarrhea, mucositis, and alopecia and general symptom management, and information support group that can be followed. 7 Educating the patient and family is very important before administration of chemotherapy agents and it is the nurse's responsibility to educate patients and families, especially information about the side effects of treatment and interventions which can minimize these effects.…”

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confidence: 99%

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The effect of educational intervention on the quality of life of acute lymphocytic leukemia who undergoing chemotherapy

Novrianda

Khairina

2015

Int J Res Med Sci

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“…2 At Dr. Sardjito General Hospital, Yogyakarta, there were 159 pediatric patients diagnosed with acute lymphoblastic leukemia (ALL) from January 2004 to January 2007. 3 There were 1,124 children under 18 years with newlydiagnosed cancer during 10 years (January 2000 to December 2009), with six most common diagnosis were ALL (40.6%), acute myeloblastic leukemia (13.9%), retinoblastoma (6.7%), neuroblastoma (5.5%), Wilm's tumor or nephroblastoma (4.5%) and Non-Hodgkin lymphoma (4.4%). According to age group, most children (58.2%) were diagnosed with cancer during infancy and early childhood (0-5 years).…”

Section: Introductionmentioning

confidence: 99%

The relationship between fatigue and play activities of children with acute lymphoblastic leukemia receiving chemotherapy

2015

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Health-related quality of life assessment in Indonesian childhood acute lymphoblastic leukemia

Cited by 78 publications

References 27 publications

Quality of life during active treatment for pediatric acute lymphoblastic leukemia

Quality of life during active treatment for pediatric acute lymphoblastic leukemia

The effect of educational intervention on the quality of life of acute lymphocytic leukemia who undergoing chemotherapy

The relationship between fatigue and play activities of children with acute lymphoblastic leukemia receiving chemotherapy

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