Health‐related quality of life as a prognostic factor in patients with advanced cancer

Steel, Jennifer L.; Geller, David A.; Robinson, Tiana L.; Savkova, Alexandra; Brower, Deborah; Marsh, J. Wallis; Tsung, Allan

doi:10.1002/cncr.28902

Cited by 34 publications

(33 citation statements)

References 27 publications

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“…In particular, the baseline physical functioning domain has been associated with survival in patients with non-small cell lung cancer [5] and tumor-node-metastasis (TNM) stages III and IV colorectal cancer [6]. A recent study revealed that physical well-being, evaluated using the Functional Assessment of Cancer Therapy-Hepatobiliary, could be used as a prognostic marker in patients with various stages of HCC and cholangiocarcinoma [7]. However, few studies have explored the association of HRQOL and prognosis in patients with HCC.…”

Section: Introductionmentioning

confidence: 99%

Longitudinal alterations in health-related quality of life and its impact on the clinical course of patients with advanced hepatocellular carcinoma receiving sorafenib treatment

et al. 2016

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BackgroundThis study aimed to identify the health-related quality of life (HRQOL) domains associated with prognosis by assessing longitudinal alterations in HRQOL in patients with advanced hepatocellular carcinoma receiving sorafenib.MethodsWe prospectively assessed HRQOL by administering the SF-36 questionnaire 3-monthly to consecutive patients with advanced hepatocellular carcinoma receiving sorafenib. We evaluated the impact of HRQOL on their overall survival and duration of treatment with sorafenib using Cox's proportional hazards model.ResultsThere were 54 participants: 42 (78 %) were male, the median age was 71 years, 24 (44 %) had hepatitis C virus infection, 33 (61 %) had Child-Pugh scores of 5, and 30 (56 %) had TNM stage IV hepatocellular carcinoma. The median overall survival and treatment duration were 9 and 5 months, respectively, and 40 patients (74 %) died. Thirteen patients receiving sorafenib over a 1-year period maintained all domain scores >40, without a significant decline during the treatment period. In contrast, physical functioning, physical role, and vitality scores declined continuously and significantly in the year before death (in the 40 patients who died). Previous curative treatment and physical functioning scores ≥40 at baseline were significantly associated with longer overall survival by multivariate analysis. Social functioning scores ≥40, absence of vascular invasion, and lower DCP value were significant predictors of longer treatment duration.ConclusionsHRQOL was not significantly impaired in those patients who were able to complete a 1-year course of sorafenib treatment. Baseline physical functioning scores ≥40 and social functioning scores ≥40 were significantly associated with longer overall survival and longer treatment duration, respectively. Thus, HRQOL could be a valuable marker to predict the clinical course of patients with advanced hepatocellular carcinoma receiving sorafenib.Electronic supplementary materialThe online version of this article (doi:10.1186/s12885-016-2908-7) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

Longitudinal alterations in health-related quality of life and its impact on the clinical course of patients with advanced hepatocellular carcinoma receiving sorafenib treatment

et al. 2016

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“…We found that employment status was only significantly associated with depression in males, but not in female patients, which has not been previously reported. Based on these findings, targeted and tailored interventions to reduce depressive symptoms are warranted to treat those from underserved populations to maintain HRQoL and potentially improve survival …”

Section: Discussionmentioning

confidence: 99%

Socioeconomic disparities of depressive symptoms and cytokines in hepatocellular carcinoma

et al. 2019

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Objective To examine the associations among socioeconomic factors, depressive symptoms, and cytokines in patients diagnosed with hepatocellular carcinoma (HCC). Methods A total of 266 patients diagnosed with HCC were administered a battery of questionnaires including a sociodemographic questionnaire and the Center for Epidemiologic StudiesDepression (CES‐D) scale. Blood samples were collected to assess serum levels of cytokines using Luminex. Descriptive statistics, Mann‐Whitney U, Kruskal‐Wallis, linear regression, and Bonferroni corrections were performed to test the hypotheses. Results Of the 266 patients, 24% reported depressive symptoms in the clinical range (CES‐D ≥ 22). Females had higher CES‐D score than males (Mann‐Whitney U = 7135, P = .014, Padj = .028). Being unemployed/disabled (Kruskal‐Wallis = 14.732, P = .001, Padj = .005) was found to be associated with higher depressive symptoms in males but not in females. Serum level of IL‐2 (Kruskal‐Wallis = 17.261, P = .001, Padj = .005) were found to be negatively associated with education level. Gender (β = .177, P = .035), income (β = −.252, P = .004), whether the patient's income met their basic needs (β = .180, P = .035), and IL‐1β (β = −.165, P = .045) independently predicted depressive symptoms and together explained 19.4% of variance associated with depressive symptoms. Conclusions Sociodemographic and socioeconomic factors were predictive of inflammation and depressive symptoms. Recommendations include the development of gender‐targeted interventions for patients diagnosed with HCC who have low socioeconomic status (SES) and may suffer from depressive symptoms.

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“…It is known that the suffering from cancer causes signs and symptoms that reflect in patient's capacity of performing daily activities, often with the need for specific dietary menus (especially hypercaloric ones), the need of dressing and the use of various accessories (probes, drains, catheters) (7,16) .…”

Section: Discussionmentioning

confidence: 99%

“…In a chronic disease process such as cancer, emotional conflicts may appear, particularly if the disease is culturally stigmatized. The presence of signs and symptoms that interfere with vital energy, such as fatigue, fever, loss of appetite, among others, may also justify refusal or resistant behaviors to educational processes (16)(17) .…”

Section: Discussionmentioning

confidence: 99%

Educational pamphlets on health: a reception study

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Magalhães

et al. 2015

Rev. esc. enferm. USP

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Objective: Identifying the socioeconomic and cultural profile of users/readers of educational pamphlets, characterizing the context of the reading material and people involved; describing the user/reader evaluation on language and style used, as well as content range or limitations, and its characterization as an educational material in assisting users for meeting homecare demands. Method: A reception, cross-sectional, qualitative study. 27 respondents who had received five educational pamphlets were interviewed on Oncology signs and symptoms during primary care consultations. Results: Study participants were adults, with average schooling of more than 10 years and low income. Pamphlets were assessed as appropriate for consistent language, quantity and quality of content, and especially in relation to the capacity of helping in the homecare decision making process. The importance of receiving pamphlets at the initial stage of the disease was verified. Conclusion: Users acceptance was positive and the study revealed aspects that should be reinforced in the creation of educational pamphlets.

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Health‐related quality of life as a prognostic factor in patients with advanced cancer

Cited by 34 publications

References 27 publications

Longitudinal alterations in health-related quality of life and its impact on the clinical course of patients with advanced hepatocellular carcinoma receiving sorafenib treatment

Longitudinal alterations in health-related quality of life and its impact on the clinical course of patients with advanced hepatocellular carcinoma receiving sorafenib treatment

Socioeconomic disparities of depressive symptoms and cytokines in hepatocellular carcinoma

Educational pamphlets on health: a reception study

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