Health-Related Quality of Life and Metabolic Control in Children and Adolescents with Type 1 Diabetes Mellitus

Abstract

Objective:The burdens imposed on a child and his/her parents by a diagnosis of type 1 diabetes mellitus (T1DM) adversely affect their health-related quality of life (HRQoL). HRQoL is important for prognosis and is related to metabolic control. To evaluate the HRQoL of Turkish children and adolescents with T1DM and to assess the correlation of HRQoL subscales (including physical and psychosocial health) with metabolic control, and particularly with hypo- and hyperglycaemic episodes.Methods:This cross-sectional study included 70 participants with T1DM aged between 8 and 18 years (study group) and 72 healthy controls who were matched to the study group in terms of age, gender, and sociodemographic characteristics (control group), and their parents. HRQoL was determined by the Pediatric Quality of Life Inventory. As an indicator of metabolic control, the most recent hemoglobin A1c (HbA1c) levels were obtained and the number of hypo- and hyperglycaemic episodes over the past one month were checked.Results:The study group had similar HRQoL scores for children’s self-reports and parents’ proxy-reports to the control group apart from a decreasing psychosocial health score for parents’ proxy-reports in the study group. Although HbA1c level was not related to HRQoL scores, lower number of hypo- and hyperglycaemic episodes were associated with an increase in psychosocial health scores and physical health scores as well as an increase in the total score for parents’ proxy-reports.Conclusion:Although there was no correlation between metabolic control and HRQoL in children’s self-reports, the improving HRQoL levels in parents’ proxy-reports were associated with good metabolic control.

Struggling and Overcoming Daily Life Barriers Among Children With Congenital Heart Disease and Their Parents in the West Bank, Palestine

“…However, this systematic review found that disease-specific psychosocial aspects, such as the negative impact of diabetes on daily functioning, worries, and lower satisfaction with life, were certainly present in patients with T1D (Nieuwesteeg et al, 2012). Another explanation for the similar level of self-perceived health in this thesis could be that children with T1D may have adapted to live with a chronic disease as argued by Caferoğlu, İnanç, Hatipoğlu, and Kurtoğlu (2016). It is noticeable that PedsQL 4.0 GCS did not capture disease-specific aspects which might affect the health and wellbeing of children with T1D (Study III) but the instrument allows for comparison with a healthy reference group.…”

Health-related quality of life in a group of Egyptian children and adolescents with type 1 diabetes: relationship to microvascular complications

“…A control group of 60 healthy children and adolescents (recruited from the outpatient clinics and relatives of the diabetic children), with no chronic diseases or obvious medical disorders and not receiving any medications were matched for age, sex, and socioeconomic levels with the study diabetic group. They were 23 (38.3%) males and 37 (61.7%) females, with age range (Alvarado-Martel et al 2015;American Diabetes Association 2018;Anderson et al 2017;Arabiat and Al Jabery 2013;Bahia et al 2017;Bai et al 2017;Barcellos et al 2014;Baş et al 2011;Bisegger et al 2005;Caferoğlu et al 2016;Chawla 2004) years with a mean of 12.43 ± 2.66 years.…”

“…They were 12 (40.0%) males and 18 (60.0%) females. Group II included 30 children and adolescents with T1DM, and they had one or more diabetic complications, with age range (Arabiat and Al Jabery 2013;Bahia et al 2017;Bai et al 2017;Barcellos et al 2014;Baş et al 2011;Bisegger et al 2005;Caferoğlu et al 2016;Chawla 2004) years with a mean of 14.80 ± 2.35 years. They were 10 (33.3%) males and 20 (66.7%) females.…”

“…It has been shown that poor HRQOL in patients with diabetes is associated with adverse outcomes and increased mortality (Kleefstra et al 2008;de Souza et al 2015). Enhancing QOL and well-being in people with diabetes is as important as metabolic control and prevention of secondary morbidity (Caferoğlu et al 2016).…”

Gender Differences In Quality Of Life In Adults With Long-Standing Type 1 Diabetes Mellitus

“…Interestingly, glycemic instability emerged as a female-speci c factor which adversely affected QoL. Published data are not consistent with the association of QoL and metabolic control, assessed by HbA 1c levels [11,[36][37][38][39], the standard method for assessing glycemic control. However, used as a sole marker of glycemic control, HbA 1c does not re ect intra-and interday glycemic excursions that may lead to hypoglycemia or hyperglycemia events.…”