Health-Related Quality of Life among Patients with Hepatitis C Virus Infection: A Cross-Sectional Study in Jianping County of Liaoning Province, China

Zhang, Hairui; Ren, Rong; Liu, Jinlin; Pan, Guowei; Men, Ke; Ma, Li

doi:10.1155/2020/6716103

Cited by 7 publications

(10 citation statements)

References 28 publications

(31 reference statements)

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“…The patient population consisted of patients with autoimmune or cholestatic liver disease (19 studies), [8] , [9] , [10] , [11] , [12] , [13] , [14] , [15] , [16] , [17] , [18] , [19] , [20] , [21] , [22] , [23] , [24] , [25] , [26] chronic hepatitis B or C (35 studies), [27] , [28] , [29] , [30] , [31] , [32] , [33] , [34] , [35] , [36] , [37] , [38] , [39] , [40] , [41] , [42] , [43] , [44] , [45] , [46] , [47] , [48] , [49] , [50] , [51] , [52] , [53] , [54] , [55] , [56] , [57] , [58] , [59] , [60] , [61] NAFLD or NASH (15 studies), [62] , [63] , [64] , [65] , [66] , [67] , [68] , [69] , [70] , [71] , [72] , …”

Section: Resultsunclassified

“… 9 , 12 , [22] , [23] , [24] , [25] , [26] Mental, physical, and social factors, such as body composition, comorbidities, fatigue, lack of information on the disease, and low income together with patient characteristics, such as younger age at diagnosis, alcohol use, and female sex, were associated with impaired quality of life. 8 , 10 , 11 , 15 , 18 , 21 , 30 , 33 , 35 , [42] , [43] , [44] , 48 , 49 , 58 , 59 , 66 , 67 , 72 , 74 …”

Section: Resultsmentioning

confidence: 99%

“…They were shocked to be diagnosed with a liver disease, which triggered a life transition, 29 , 37 , 55 , 80 , 88 although patients with hepatitis B also understood the disease as an intergenerational family condition. 59 Patients generally tried to manage the disease in a positive way, but a lack of knowledge could result in insufficient self-care. This resulted in a feeling of failure.…”

Section: Resultsmentioning

confidence: 99%

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Quality of life and unmet needs in patients with chronic liver disease: A mixed-method systematic review

Grønkjær¹,

Lauridsen²

2021

JHEP Reports

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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Section: Resultsunclassified

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Quality of life and unmet needs in patients with chronic liver disease: A mixed-method systematic review

Grønkjær¹,

Lauridsen²

2021

JHEP Reports

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“…( 7 ) The EuroQol Group 5 Dimension (EQ‐5D) is designated as one of the most preferred tools for quantifying HRQoL in the general population and in a pathological entity, namely, chronic liver disease where its validity has been widely affirmed. ( 8 , 9 , 10 , 11 , 12 , 13 ) The EQ‐5D questionnaire covers a broad array of health issues, including mobility, self‐care, usual activities, pain and anxiety/depression, and subsequently generating a utility index. Of note, it is advantageous to compare the retrieved utility index among different studies in case of lacking control groups or available population norms.…”

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confidence: 99%

Health‐Related Quality of Life and Its Contributors According to a Preference‐Based Generic Instrument in Cirrhosis

Hui

et al. 2021

Hepatol Commun

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It is essential to determine contributors around impairment in health-related quality of life (HRQoL) in patients with cirrhosis aiming at improving health care and therapeutic strategy. Studies simultaneously incorporating disease severity based on biochemical parameters and other physical/psychological effects (i.e., sleep disturbance and frailty) are heterogeneous and the subject of the present study. We analyzed and compared HRQoL, using the EuroQol Group 5 Dimension (EQ-5D) questionnaire and the utility index retrieved, in patients with cirrhosis and across groups stratified by sleep disturbance or frailty phenotype. Sleep disturbance and frailty were determined by the Pittsburgh Sleep Quality Index (PSQI) and Frailty Index, respectively. Multiple linear regression was implemented to clarify contributors of poor HRQoL. In this cohort of 227 patients with mean age of 61.7 years and 47.2% male, more than half of the study population represented impairment in HRQoL in at least one domain, according to EQ-5D. Furthermore, sleep disturbance and frailty have proved to be independently associated with poor HRQoL in two separate regression models, whereas conventional scoring systems such as Child-Pugh classification and Model for End-Stage Liver Disease are not closely relevant. Intriguingly, not all health domains within EQ-5D correlated well with PSQI and Frailty Index, with the exception of usual activities. Pain and anxiety/depression were the most frequently affected HRQoL domains even in patients without sleep disturbance or frailty. Conclusion: Impaired HRQoL is prevalent in patients with decompensated cirrhosis. Sleep disturbance and frailty are independently associated with poor HRQoL. It is imperative to timely intervene with these symptoms and deliver tailored health care. (Hepatology Communications 2022;6:610-620).P atients with cirrhosis often experience impairment in health-related quality of life (HRQoL), while this phenotypic perturbation is more profound in decompensated conditions. (1) More recently, a prospective cohort study conducted by Kok et al. also clarified that poor HRQoL is independently related to increased mortality and unplanned hospitalization in patients with cirrhosis. (2) However, most literature in the realm of hepatology has only taken into account ameliorating disease severity or delaying its progression, referring to better biochemical parameters and prolonged survival time. (3) In actuality, it is essential to implement comprehensively holistic evaluation pertaining to HRQoL both in daily practice

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“…Previous studies had shown that assessing HRQOL is of utmost importance to community health. It was reflected to be the gold standard to report pay papatients'xperiences with both illness and treatment (25)(26)(27)(28)(29).…”

Section: Discussionmentioning

confidence: 99%

Quality of Life of Chronic Hepatitis C Patients Receiving Sovaldi Treatment Regimen at Sharq Almadina Hospital in Alexandria

Gamaleldin

Shokeir

Abdelaziz³

et al. 2022

Suez Canal University Medical Journal

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Background: Hepatitis C virus (HCV) infection is a worldwide public health problem, affecting about 3% of the world's population. The introduction of sofosbuvir (Sovaldi) markedly changed therapeutic outcomes. The assessment of HRQoL in HCV patients under treatment might help to better understand the effect of treatment on the patient's quality of life. Aim: The study was conducted to assess the quality of life of chronic hepatitis C patients receiving Sovaldi at the outpatient hepatology clinic in Sharq Almadina hospital. Patients and Methods: A cross-sectional survey was conducted among chronic hepatitis C patients receiving Sovaldi treatment regimen for at least 3 months. Data was collected from the studied CHCV patients using face-to-face interviews including personal & sociodemographic characteristics, The chronic liver disease questionnaire (CLDQ) to assess health-related quality of life, and the translated Arabic version of the short-form (SF 36) generic quality of life questionnaire. In addition, reviewing the medical records of studied CHCV patients to collect data about their laboratory findings was done. Results: More than two-thirds of studied patients (69.1%) discovered the disease during the National Egyptian Campaign. The overall median value of SF-36Q items was 53.19 indicating a poor HRQoL. There were significant positive correlations between the majority of SF-36Q individual domain scores and that for CLDQ P <0.001 as well as the total scores. Conclusions: There were significant positive correlations between the majority of SF-36Q individual domain scores and that for CLDQ as well as the total scores.

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Health-Related Quality of Life among Patients with Hepatitis C Virus Infection: A Cross-Sectional Study in Jianping County of Liaoning Province, China

Cited by 7 publications

References 28 publications

Quality of life and unmet needs in patients with chronic liver disease: A mixed-method systematic review

Quality of life and unmet needs in patients with chronic liver disease: A mixed-method systematic review

Health‐Related Quality of Life and Its Contributors According to a Preference‐Based Generic Instrument in Cirrhosis

Quality of Life of Chronic Hepatitis C Patients Receiving Sovaldi Treatment Regimen at Sharq Almadina Hospital in Alexandria

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