Health-related quality of life among paediatric survivors of primary brain tumours and acute leukaemia

Pogorzała, Monika; Styczyński, Jan; Kurylak, Andrzej; Dębski, Robert; Wojtkiewicz, Magdalena; Wysocki, Mariusz

doi:10.1007/s11136-009-9580-1

Cited by 37 publications

(59 citation statements)

References 31 publications

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“…The clinical importance of this small difference is therefore questionable. However, our findings are in line with findings from other studies that described impaired HRQoL in similar domains, using other HRQoL measures [9,10,[19][20][21]. The reduced HRQoL on the Motor and Cognitive functioning scales can be explained by the high proportion of neurologic impairments seen in these children.…”

Section: Discussionsupporting

confidence: 92%

“…Monitoring of health-related quality of life (HRQoL) is done, for example, in childhood survivors who are treated for a pilocytic astrocytoma [9][10][11], low-grade glioma [12], high-grade glioma [13], craniopharyngioma [14,15], medulloblastoma [16,17], and in heterogeneous groups [18][19][20][21][22][23][24]. In most of these studies, survivors reported a variety of degree of reduction in HRQoL compared with healthy age mates [9,10,[13][14][15][16][18][19][20][21][22][23][24]. This could be explained by the heterogeneity of brain tumors and their treatments.…”

Section: Introductionmentioning

confidence: 99%

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Health-related quality of life and emotional problems in children surviving brain tumor treatment: A descriptive study of 2 cohorts

Dessens

Herwerden

Aarsen

et al. 2016

Pediatric Hematology and Oncology

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KEYWORDSBrain diseases; brain neoplasms; child behavior disorders; cohort study; quality of life ABSTRACTThe survival of childhood brain tumors has improved in the past 30 years, but acquired brain injury due to damage caused by tumor invasion and side effects of different treatment modalities frequently occurs. This study focused on residual impairments, health-related quality of life (HRQoL), and emotional and behavioral problems in 2 cohorts of survivors diagnosed and treated for various types of brain tumors. In the 2014 cohort, children reported less negative emotions than healthy children. No increase in emotional or behavioral problems were reported by children in both cohorts, whereas parents reported problems in social functioning and isolation related to a delay in emotional development. Children surviving brain tumor treatment have a reduced quality of life. The authors therefore recommend regular screening of HRQoL and emotional and behavioral problems and referral to specific aftercare.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Health-related quality of life and emotional problems in children surviving brain tumor treatment: A descriptive study of 2 cohorts

Dessens

Herwerden

Aarsen

et al. 2016

Pediatric Hematology and Oncology

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“…Thus, the tumor histology may favor a better prognosis, and a better overall QOL in pediatric LGG patients. Studies have reported that pediatric patients with CNS tumors have overall lower QOL than pediatric patients undergoing leukemia treatment [8, 9]. In contrast, the current study population reports higher QOL functional scores in comparison to adult long-term survivors of acute myeloid leukemia (AML).…”

Section: Discussionmentioning

confidence: 63%

“…Reports assessing QOL in pediatric patients have demonstrated lower overall QOL in children with CNS tumors compared to their healthy counterparts [9, 18]; however, those patients were either undergoing or within one year of treatment completion, while the majority of the participants in this study were several years post treatment. In comparison to previously published reports of adult patients with LGGs, the current study of adult survivors of pediatric LGGs appear to have better overall QOL scores.…”

Section: Discussionmentioning

confidence: 95%

Health related quality of life (HRQOL) in long-term survivors of pediatric low grade gliomas (LGGs)

et al. 2014

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BACKGROUND The purpose of this study was to assess the health-related quality of life (HRQOL) and the impact of treatment on HRQOL in long-term survivors of pediatric low-grade gliomas (LGGs) using an adult instrument. METHODS QOL of 121 patients with a diagnosis of LGG from the Mayo Clinic were assessed using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC-QLQ-C30 for cancer in general) and (EORTC QLQ-BN20 specific for brain tumors). RESULTS Median follow-up was 21.9 years for the participants. Median age at diagnosis was 11.8 years and at assessment was 33 years. Mean (standard deviation) global QOL score for the study was 78 (18) and 76.4 (22.8) in a reference population of healthy adults. Using QLQ-C30, radiation treated patients compared to non-radiation patients reported lower physical functioning (p=0.002), role functioning (p=0.004), and more constipation problems (p<0.001). Patients with tumor recurrence reported lower role functioning (p=0.016), social functioning (p=0.040), and more financial problems (p=0.029) compared to their counterparts. Using QLQ-BN20, patients with deep tumors compared to cortical tumors reported more bladder control problems (p=0.016). Radiation treated patients also reported more bladder control problems (p<0.001) compared to their counterparts. In the multivariable analysis, radiation therapy remained an independent predictor of physical and role functioning as well as symptoms related to brain tumors like visual disorders and motor dysfunction. CONCLUSION Global QOL of long-term survivors of pediatric LGGs is similar to that of a reference population of healthy adults. The following tumor and treatment related factors were most consistently associated with poorer QOL: CNS tumor location, post-operative radiation, and tumor recurrence. Future studies are necessary to identify strategies to improve QOL in this subgroup of patients.

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“…The HRQOL of oncologic paediatric patients has been the focus of many studies and is seen to be lower in patients under treatment and who have survived cancer as compared to the healthy population (Pogorzala et al, 2010;Ribi et al, 2005;Speechley, Barrera, Shaw, Morrison, & Mounse, 2016). The measurement of HRQOL in clinical practice represents a tendency to consider the health of patients in their entirety.…”

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confidence: 99%

Health‐related quality of life of Brazilian children and adolescents with benign and malignant solid tumours: A prospective cohort study during the first year after hospital admission

et al. 2019

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Introduction This study aims to assess the impact of paediatric benign and malignant solid tumours and its treatment on the health‐related quality of life of children and adolescents who were followed up in a Reference Center in Pediatric Oncology in Rio de Janeiro. Methods It is a prospective cohort study. Quality of life assessment was performed using the PedsQL™ 4.0 Generic Core Scales and PedsQL™ 3.0 Cancer Module protocols three times: during hospital admission (T1), 6 months after admission (T2) and 1 year after admission (T3). Results We evaluated 132 patients, 59 men and 73 women, aged 2–17 years. In PedsQL™4.0, the Emotional Functioning scale was the one with the worst scores, while the scores on the Social Functioning scale was the best. In PedsQL™ 3.0, the worst domains were Procedural Anxiety and Worry. Patients with malignant bone tumours had the worst health‐related quality of life. The group who received only surgery had better results. Total scores of PedsQL™4.0 and PedsQL™ 3.0 improved between T1 and T3. Conclusion Children and adolescents with malignant and benign neoplasms undergo changes in quality of life as a result of the disease and treatment, but an improvement has been observed over time.

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Health-related quality of life among paediatric survivors of primary brain tumours and acute leukaemia

Abstract: Evaluation of HRQL should be treated as an additional independent parameter in an assessment of the long-term results of oncological treatment.

Cited by 37 publications

References 31 publications

Health-related quality of life and emotional problems in children surviving brain tumor treatment: A descriptive study of 2 cohorts

Health-related quality of life and emotional problems in children surviving brain tumor treatment: A descriptive study of 2 cohorts

Health related quality of life (HRQOL) in long-term survivors of pediatric low grade gliomas (LGGs)

Health‐related quality of life of Brazilian children and adolescents with benign and malignant solid tumours: A prospective cohort study during the first year after hospital admission

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