Health-related Quality of Life After Cardiac Transplantation: Results of a UK National Survey With Norm-based Comparisons

Saeed, Imran; Rogers, Chris; Murday, Andrew J.

doi:10.1016/j.healun.2008.03.013

Cited by 35 publications

(16 citation statements)

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“…Depressive and anxiety symptomatologies are a frequent finding after transplantation and have been reported in numerous studies [4,6,8-10,13,30,31]. …”

Section: Discussionmentioning

confidence: 99%

Overall mental distress and health-related quality of life after solid-organ transplantation: results from a retrospective follow-up study

Baranyi

Krauseneck

Rothenhäusler

2013

Health Qual Life Outcomes

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BackgroundOur retrospective follow-up study aimed to explore the degree of overall mental distress in a cohort of solid-organ transplantation (SOT) recipients after liver, heart or lung transplantation. Furthermore, we investigated how overall mental distress is linked to health-related quality of life.Methods123 SOT patients treated during the study period were enrolled in this investigation at a mean of 24.6 months (SD=11.6) after transplantation. Before transplantation, the Transplant Evaluation Rating Scale (TERS) was used to classify the level of adjustment in psychosocial functioning among transplantation candidates. After transplantation, recipients completed a research battery, which included the SCL-90-R, and the SF-36.Results39 (31.7%) transplantation recipients had clinically significant overall mental distress as measured on the Global Severity Index of the SCL-90-R. Obsessive-compulsive symptoms (92.3%), somatization symptoms (87.2%), anxiety symptoms (84.6%), depression symptoms (82.1%) and phobic anxiety symptoms (69.2%) were a frequent finding.Transplantation recipients with overall mental distress had significant lower levels of adjustment in psychosocial functioning before transaplantation than those without overall mental distress as measured in the TERS. Transplantation-related overall mental distress symptomatology was associated with maximal decrements in health-related quality of life.ConclusionTransplantation recipients may face major transplantation- and treatment-related overall mental distress and impairments to their health-related quality of life. Further, overall mental distress is a high-risk factor in intensifying impairments to patients’ overall quality of life.

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“…Depressive and anxiety symptomatologies are a frequent finding after transplantation and have been reported in numerous studies [4,6,8-10,13,30,31]. …”

Section: Discussionmentioning

confidence: 99%

Overall mental distress and health-related quality of life after solid-organ transplantation: results from a retrospective follow-up study

Baranyi

Krauseneck

Rothenhäusler

2013

Health Qual Life Outcomes

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“…The main goals of heart transplantation are to increase the life span of patients with advanced heart disease and to optimize their health‐related quality of life (HRQoL), especially when these benefits cannot be guaranteed with the medical treatments available. The clinical effectiveness of heart transplantation is analyzed by comparing outcomes with those of other medical procedures, in terms of both survival rates and patient‐reported outcomes (PRO) . One of the most commonly used PRO measures is HRQoL, which can be defined as follows: “The value assigned to duration of life as modified by the impairments, functional states, perceptions, and social opportunities that are influenced by disease, injury, treatment, or policy .” Evidence from research has shown that patients' HRQoL after allograft improves in comparison with their situation before surgery .…”

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confidence: 99%

Health‐related quality of life, social support, and caregiver burden between six and 120 months after heart transplantation: a Spanish multicenter cross‐sectional study

Delgado

Almenar

González‐Vílchez

et al. 2015

Clinical Transplantation

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A multicenter cross-sectional study was conducted to determine the current heart transplant (HTx) outcomes in Spain. Clinical and functional status, health-related quality of life (HRQoL), social support, and caregiver burden were analyzed in 303 adult transplant recipients (77.9% males) living with one functioning graft. Mean age at time of HTx (SD) was 56.4 (11.4) years, and the reason for transplantation in all patients was congestive heart failure. All patients had received a first heart transplant 6 (± 1), 12 (± 2), 36 (± 6), 60 (± 10), or 120 (± 20) months previously. Participants completed the Kansas City Cardiomyopathy Questionnaire (KCCQ), the EQ-5D, the Duke-UNC Functional Social Support Questionnaire, and the Zarit Caregiver Burden Scale. Reasonable HRQoL, social support, and caregiver burden levels were found at all time points, although a slight decrease in HRQoL was recorded at 120 months (p ≤ 0.033). Multivariate regression analyses showed that complications, comorbidities, and hospitalizations were associated with HRQoL (EQ-5D: 48.4% of explained variance, F4,164 = 38.46, p < 0.001; KCCQ overall summary score: 45.0%, F3,198 = 54.073, p < 0.001). Patient functional capabilities and complications affected caregiver burden (p < 0.05). In conclusion, HTx patients reported reasonable levels of HRQoL with low caregiver burden. Clinical variables related to these outcomes included functional status, complications, and number of admissions.

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“…T he overall aim of solid organ transplantation is not only to ensure patient survival but also to improve health-related quality of life (HRQoL), an important outcome measure used to assess the long-term success after transplantation (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12). HRQoL represents a multidimensional construct comprising the physical, mental, and social component of a patient's selfperception of his or her health status at a specific point of time.…”

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confidence: 99%

Health-Related Quality of Life in Long-Term Survivors After Heart and Lung Transplantation: A Prospective Cohort Study

et al. 2010

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Health-related Quality of Life After Cardiac Transplantation: Results of a UK National Survey With Norm-based Comparisons

Cited by 35 publications

References 11 publications

Overall mental distress and health-related quality of life after solid-organ transplantation: results from a retrospective follow-up study

Overall mental distress and health-related quality of life after solid-organ transplantation: results from a retrospective follow-up study

Health‐related quality of life, social support, and caregiver burden between six and 120 months after heart transplantation: a Spanish multicenter cross‐sectional study

Health-Related Quality of Life in Long-Term Survivors After Heart and Lung Transplantation: A Prospective Cohort Study

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