Health Related Quality of Life in Patients with Bladder Cancer: A Cross-Sectional Survey and Validation Study of the Hungarian Version of the Bladder Cancer Index

Abstract

Health-related quality of life (HRQoL) is an important outcome in oncology care although an underexplored area in bladder cancer (BC). Our aims were to assess HRQoL of patients with BC, analyse relationships between diverse HRQoL measures and validate the Hungarian version of the Bladder Cancer Index (BCI) questionnaire. A cross-sectional survey was performed among patients with BC (N = 151). Validated Hungarian versions of the FACT-Bl, SF-36 and EQ-5D were applied and SF-6D was derived. Psychometric analysis of the Hungarian BCI was performed. Pearson correlations between the five measures were analysed. Deterioration in SF-36 Physical Functioning was detected among patients aged 45-64 years. The EQ-5D score did not differ significantly from the age-matched population norm. Correlations between the FACT-Bl, EQ-5D and SF-6D utility measures were strong (r > 0.6). Cronbach alpha coefficients of the Hungarian BCI ranged from 0.75 to 0.97 and factor analysis confirmed that data fit to the six predefined subdomains. Test-retest correlations (reliability, N = 50) ranged from 0.67 to 0.87 and interscale correlations between urinary, bowel and sexual BCI domains were weak or moderate (r = 0.29 to 0.49). Convergent validity revealed a stronger correlation with FACT-Bl (r = 0.126 to 0.719) than with generic health state scores (r = 0.096 to 0.584). Results of divergent validity of the Hungarian BCI by treatment groups by Kruskal Wallis test were promising although limited by low sample sizes in cystectomy subgroups. Generic health state measures have limited capacity to capture HRQoL impact of BC. Validity tests yielded favourable results for the Hungarian BCI. Mapping studies to estimate utility scores from FACT-Bl are encouraged but less recommendable with the BCI.

EQ-5D in Central and Eastern Europe: 2000–2015

“…[29], we found only four oncological studies from CEE: breast cancer [73], lymphoma, leukaemia and myeloma multiplex [70], bone metastases in breast cancer or myeloma multiplex [60] and bladder cancer [14].…”

“…Official language versions are available for all the national languages of CEE countries. On the contrary, only very limited data is available from CEE countries using other preference-based measures such as SF-6D [12][13][14] and Health Utilities Index (HUI) [15] or directly measured utilities such as time trade-off or standard gamble [16][17][18][19]. Of note, HUI has not been validated in the national languages of CEE countries with the exception of Austria.…”

Validation of the Arabic version of the Functional Assessment of Cancer Therapy-Bladder questionnaire in Egyptian patients with bladder cancer

“…It objectively assesses the four subscales of the FACT-G, physical, social, emotional and functional well-being, plus a bladder cancer subscale that assess urinary tract, intestinal and sexual symptoms [3] . Validated versions of the FACT-Bl have been published in the Japanese, Chinese, Hungarian, and Italian languages [4] , [5] , [6] , [7] .…”

A gyógyszeresen kezelt jóindulatú prosztatamegnagyobbodásban szenvedő betegek életminősége Magyarországon – Keresztmetszeti felmérés hat urológiai centrumban

“…Az EU jelenlegi 27 tagállamában az egész-ségügyi kiadások az előrejelzések szerint 2010 és 2060 között a GDP 7,1%-ról 8,4%-ra emelkedik, ami tisztán az öregedő populáció egészségügyi kiadásokra gyakorolt hatásának tulajdonítható (5). Az életkorral összefüggő betegségek, mint például a BPH, a 2-es típusú cukorbetegség, a demencia, csontritkulás, húgy-hólyagrák és prosztatarák mára az egészségügyi finanszírozás fő költségtényezőivé váltak (6)(7)(8)(9)(10)(11)(12)(13)(14). A várható élettartam nö-vekedése, a fejlett országokban megfigyelhető demográfiai öregedés és a BPH magas előfordulási gyakorisága miatt egyre több férfi vesz igénybe egészségügyi szolgáltatásokat a BPH tünetei miatt (15,16).…”