Health Outcomes and Primary Adherence to Secondary Prevention Treatment after St-Elevation Myocardial Infarction: a Spanish Cohort Study

López, Ana Padilla; Alós-Almiñana, Manuel; Peris, José-Esteban

doi:10.1007/s12265-020-10045-0

Cited by 2 publications

(4 citation statements)

References 41 publications

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“…19 Additionally, in the study by Padilla et al, prior history of a cardiovascular event was associated with primary non-adherence, perhaps due to previous experiences regarding the use of cardiovascular drugs. 18 In this study, no associations were found between medical history of stroke and primary non-adherence. However, the number of primary non-adherers with a prior history of stroke was small in this study.…”

Section: Discussioncontrasting

confidence: 56%

“…Similar findings were seen in a Spanish study investigating primary adherence in patients with ST-elevated myocardial infarction (STEMI). 18 Both stroke and STEMI are severe health conditions associated with high morbidity and mortality. Stroke survivors may therefore initially be motivated to use preventive drugs to reduce the risk of stroke recurrence.…”

Section: Discussionmentioning

confidence: 99%

“…In accordance with previous studies, the prevalence of primary non-adherence was assessed at 1 month post hospital discharge. 18,22 A 31-day follow-up period allows time for post-stroke recovery and possible alterations in activities of daily living, for example, the introduction of home-help service. In a previous study, the prevalence of primary adherence was assessed at 7 days post hospital discharge.…”

Section: Discussionmentioning

confidence: 99%

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Primary Non-Adherence to Preventive Drugs and Associations with Beliefs About Medicines in Stroke Survivors

Westberg¹,

Sjölander²,

Glader³

et al. 2022

PPA

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Background: Medication non-adherence is a common problem in clinical practice. Little is known about stroke survivors' primary non-adherence to preventive drugs, and we hypothesised that their beliefs about medicines are associated with primary non-adherence. The objective was to describe primary non-adherence among stroke survivors and to assess associations between primary nonadherence to preventive drugs and beliefs about medicines. Methods: Questionnaires were sent to 797 individuals 3 months after stroke to assess beliefs about medicines through the Beliefs about Medicines Questionnaire (BMQ). All participants were registered in the Swedish Stroke Register (Riksstroke), and prescriptions for new preventive drugs during the hospital stay were identified through data from Riksstroke. Primary non-adherers were those who failed to fill one or more new prescriptions within 1 month of hospital discharge based on data from the Swedish Prescribed Drug Register. Differences between primary non-adherers and adherers were assessed by X 2 tests and associations between the BMQ subscales and primary non-adherence were analysed using independent two-sample t-tests and multivariable logistic regression models. Results: A total of 594 individuals responded to the survey, of which 452 received new prescriptions of preventive drugs. Overall, 53 (12%) participants were classified as primary non-adherent. Primary non-adherers were more often dependent on help or support from next of kin (p=0.032) and had difficulties with memory more often (p=0.002) than the primary adherent individuals. No statistically significant differences in BMQ subscale-scores were found between the two groups (p>0.05). Conclusion: Primary non-adherence to preventive drugs was low, and no associations were found between primary non-adherence and beliefs about medicines. Associations with cognitive impairments such as difficulties with memory and need for help from next of kin suggest that more effort is needed to help stroke survivors to start important preventive drug treatments after discharge from hospital.

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Section: Discussioncontrasting

confidence: 56%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Primary Non-Adherence to Preventive Drugs and Associations with Beliefs About Medicines in Stroke Survivors

Westberg¹,

Sjölander²,

Glader³

et al. 2022

PPA

View full text Add to dashboard Cite

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“…A relatively small number of female AMI patients were enrolled in the present study. Second, despite that the medication information was not available for each patient after 6-month follow-up, whether the medication was changed or not is important information that may also influence AMI prognosis (44). Third, the prognostic value of the four identified predictors and its cutoff point for clinical use of poor AMI prognosis deserve further investigation.…”

Section: Discussionmentioning

confidence: 99%

Prediction Factors of 6-Month Poor Prognosis in Acute Myocardial Infarction Patients

Yao

Xie

Liu

et al. 2020

Front. Cardiovasc. Med.

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Background: Acute myocardial infarction (AMI) is among the leading causes of death worldwide. Patients with AMI may have the risk of developing recurrent cardiovascular events leading to rehospitalization or even death. The present study aimed to investigate the prediction factors of poor prognosis (mortality and/or readmission) after AMI during a 6-month follow-up. Methods: A total of 206 consecutive patients hospitalized for the first visit with AMI were enrolled. Data collection included demographic characteristics, medical history, clinical information, laboratory results, and oral medications within 24 h of admission. At 1, 3, and 6 months after discharge, AMI patients were followed up to assess the occurrence of composite endpoint events including in-hospital and out-of-hospital death and/or readmission due to recurrent myocardial infarction (MI) or exacerbated symptoms of heart failure following MI. Results: After 6-month follow-up, a total of 197 AMI patients were available and divided in two groups according to good prognosis ( n = 144) and poor prognosis ( n = 53). Our data identified serum myoglobin ≥651 ng/mL, serum creatinine ≥96 μM, Killip classification 2–4, and female gender as independent predictors of 6-month mortality and/or readmission after AMI. Moreover, we demonstrated that Killip classification 2–4 combined with either myoglobin (AUC Killip class 2−4+myoglobin = 0.784, sensitivity = 69.8%, specificity = 79.9%) or creatinine (AUC Killip class 2−4+creatinine = 0.805, sensitivity = 75.5%, specificity = 77.1%) could further enhance the predictive capacity of poor 6-month prognosis among AMI patients. Conclusions: Patients with AMI ranked in the higher Killip class need to be evaluated and monitored with attention. Multibiomarker approach using Killip classification 2–4 and myoglobin or creatinine may be an effective way for 6-month prognosis prediction in AMI patients.

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Health Outcomes and Primary Adherence to Secondary Prevention Treatment after St-Elevation Myocardial Infarction: a Spanish Cohort Study

Cited by 2 publications

References 41 publications

Primary Non-Adherence to Preventive Drugs and Associations with Beliefs About Medicines in Stroke Survivors

Primary Non-Adherence to Preventive Drugs and Associations with Beliefs About Medicines in Stroke Survivors

Prediction Factors of 6-Month Poor Prognosis in Acute Myocardial Infarction Patients

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