Health influence of SARS-CoV-2 (COVID-19) on cancer:                     a review

Parise, Rachel; Li, Yiyan; Nadar, Rishi M.; Ramesh, Sindhu; Ren, Jun; Govindarajulu, Manoj; Moore, Timothy M.; Dhanasekaran, Muralikrishnan

doi:10.3724/abbs.2022147

Cited by 5 publications

(3 citation statements)

References 69 publications

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“…In addition, evidence indicated that the incidence of BLCA during the COVID-19 pandemic was lower as compared with other urinary malignancies ( 50 ). Some scholars speculated that the moderate expression of ACE2 in the bladder might be related to the low incidence of BLCA observed in previous study ( 51 ). In our current study, we provide direct evidence establishing a causal relationship between COVID-19 and a decreased risk of UTI and BLCA.…”

Section: Discussionmentioning

confidence: 83%

The genetic associations of COVID-19 on genitourinary symptoms

Chang

Lei

et al. 2023

Front. Immunol.

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BackgroundRecently emerged reports indicated that patients with coronavirus disease 2019 (COVID-19) might experience novo genitourinary symptoms after discharge. Nevertheless, the causal associations and underlying mechanisms remain largely unclear.MethodsGenome-wide association study (GWAS) statistics for COVID-19 and 28 genitourinary symptoms with consistent definitions were collected from the COVID‐19 Host Genetic Initiative, FinnGen, and UK Biobanks. Mendelian randomization (MR) analyses were applied to explore the causal effects of COVID-19 on genitourinary symptoms by selecting single-nucleotide polymorphisms as instrumental variables. Meta-analyses were conducted to evaluate the combined causal effect. Molecular pathways connecting COVID-19 and its associated disorders were evaluated by weighted gene co-expression network analysis (WGCNA) and enrichment analyses to extract insights into the potential mechanisms underlying the connection.ResultsThe MR and meta-analyses indicated that COVID-19 was causally associated with increased risk for calculus of the lower urinary tract (LUTC, OR: 1.2984 per doubling in odds of COVID‐19, 95% CI: 1.0752–1.5680, p = 0.007) and sexual dysfunction (SD, OR: 1.0931, 95% CI: 1.0292–1.1610, p = 0.004). Intriguingly, COVID-19 might exert a slight causal protective effect on the progression of urinary tract infections (UTIs) and bladder cancer (BLCA). These results were robust to sensitivity analyses. Bioinformatic analyses indicated that the inflammatory-immune response module may mediate the links between COVID‐19 and its associated disorders at the molecular level.ConclusionsIn response to post-COVID-19 symptoms, we recommend that COVID-19 patients should strengthen the prevention of LUTC and the monitoring of sexual function. Meanwhile, the positive effects of COVID-19 on UTIs and BLCA should attach equal importance.

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Section: Discussionmentioning

confidence: 83%

The genetic associations of COVID-19 on genitourinary symptoms

Chang

Lei

et al. 2023

Front. Immunol.

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“…According to Burgueño et al, the ileum, colon, and intestinal epithelial cells express ACE2 and TMPRSS2, which permits COVID-19 access into colon cells (21). Immunosuppression, malignancy, and anticancer therapy may play a role in the increased COVID-19 susceptibility in CRC (22). Therefore, it is crucial to explore how COVID-19 influences CRC patients and to search for possible therapeutic agents for CRC patients with COVID- 19. This study attempts to search the shared biological pathways and possible drugs between CRC and COVID-19 by bioinformatics and systems biology techniques.…”

Section: Introductionmentioning

confidence: 99%

The influence of COVID-19 on colorectal cancer was investigated using bioinformatics and systems biology techniques

et al. 2023

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IntroductionCoronavirus disease 2019 (COVID-19) is a global pandemic and highly contagious, posing a serious threat to human health. Colorectal cancer (CRC) is a risk factor for COVID-19 infection. Therefore, it is vital to investigate the intrinsic link between these two diseases.MethodsIn this work, bioinformatics and systems biology techniques were used to detect the mutual pathways, molecular biomarkers, and potential drugs between COVID-19 and CRC.ResultsA total of 161 common differentially expressed genes (DEGs) were identified based on the RNA sequencing datasets of the two diseases. Functional analysis was performed using ontology keywords, and pathway analysis was also performed. The common DEGs were further utilized to create a protein-protein interaction (PPI) network and to identify hub genes and key modules. The datasets revealed transcription factors-gene interactions, co-regulatory networks with DEGs-miRNAs of common DEGs, and predicted possible drugs as well. The ten predicted drugs include troglitazone, estradiol, progesterone, calcitriol, genistein, dexamethasone, lucanthone, resveratrol, retinoic acid, phorbol 12-myristate 13-acetate, some of which have been investigated as potential CRC and COVID-19 therapies.DiscussionBy clarifying the relationship between COVID-19 and CRC, we hope to provide novel clues and promising therapeutic drugs to treat these two illnesses.

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“…Besides, cancer patients exhibit poor health outcomes, possibly due to a chronic immunosuppressive state and anticancer therapies, while being more prone to infections such as SARS-CoV-2 infection. Male sex, older age, and active cancer disease or history of cancer are risk factors for COVID-19 infection potentially leading to severe complications, including morbidity and death (2).…”

Section: Introductionmentioning

confidence: 99%

Joinpoint analysis of colorectal cancer trend in the Slovakia

PHAM,

PEKARCIKOVA,

EDELSTEIN

et al. 2023

BLL

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OBJECTIVES: The aim of this study is to describe the colorectal cancer trend in the Slovakia between 2002 and 2019. BACKGROUND: In 2020, the Slovakia ranked second among the 10 countries with the highest incidence of colorectal cancer and the highest number of deaths from colorectal cancer (hereafter also referred to as CRC). METHODS: To describe the situation of CRC, indicators of incidence and mortality rates stratifi ed by age and sex for the available time period were chosen. A joinpoint regression software was used to identify changes in the trend of development. RESULTS: During the 18-year follow-up period (2002)(2003)(2004)(2005)(2006)(2007)(2008)(2009)(2010)(2011)(2012)(2013)(2014)(2015)(2016)(2017)(2018)(2019), the overall trend in colorectal cancer incidence continued to increase with an overall mean annual change of 1.3 %. The incidence of CRC tended to increase from 50 years of age and increased with age. The most pronounced increasing trend was observed in the age group of 75 years and older (AAPC in men 1.9 %, IS +1.4; +2.5 and in women 2.0 %, IS +1.6; +2.4). CRC mortality remained relatively stable for the entire 18-year period. A decreasing trend in mortality was observed in the 25-49 age group with an overall annual percentage decrease of 0.9 % (IS -1.5; -0.3), while an increasing trend was observed in the 75+ age group with an overall annual percentage increase of 1.0 % (IS +0.8; +1.3). The incidence and mortality rates in men were higher than in women. CONCLUSION: The situation of colorectal cancer trend in the Slovakia has improved compared to the previous period (1971-2001).

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Health influence of SARS-CoV-2 (COVID-19) on cancer: a review

Cited by 5 publications

References 69 publications

The genetic associations of COVID-19 on genitourinary symptoms

The genetic associations of COVID-19 on genitourinary symptoms

The influence of COVID-19 on colorectal cancer was investigated using bioinformatics and systems biology techniques

Joinpoint analysis of colorectal cancer trend in the Slovakia

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