Joinpoint analysis of colorectal cancer trend in the Slovakia

Abstract

OBJECTIVES: The aim of this study is to describe the colorectal cancer trend in the Slovakia between 2002 and 2019. BACKGROUND: In 2020, the Slovakia ranked second among the 10 countries with the highest incidence of colorectal cancer and the highest number of deaths from colorectal cancer (hereafter also referred to as CRC). METHODS: To describe the situation of CRC, indicators of incidence and mortality rates stratifi ed by age and sex for the available time period were chosen. A joinpoint regression software was used to identify changes in the trend of development. RESULTS: During the 18-year follow-up period (2002)(2003)(2004)(2005)(2006)(2007)(2008)(2009)(2010)(2011)(2012)(2013)(2014)(2015)(2016)(2017)(2018)(2019), the overall trend in colorectal cancer incidence continued to increase with an overall mean annual change of 1.3 %. The incidence of CRC tended to increase from 50 years of age and increased with age. The most pronounced increasing trend was observed in the age group of 75 years and older (AAPC in men 1.9 %, IS +1.4; +2.5 and in women 2.0 %, IS +1.6; +2.4). CRC mortality remained relatively stable for the entire 18-year period. A decreasing trend in mortality was observed in the 25-49 age group with an overall annual percentage decrease of 0.9 % (IS -1.5; -0.3), while an increasing trend was observed in the 75+ age group with an overall annual percentage increase of 1.0 % (IS +0.8; +1.3). The incidence and mortality rates in men were higher than in women. CONCLUSION: The situation of colorectal cancer trend in the Slovakia has improved compared to the previous period (1971-2001).

Determination of the Prevalence of Microsatellite Instability, BRAF and KRAS/NRAS Mutation Status in Patients with Colorectal Cancer in Slovakia

“…[ 3 ] Moreover, local researchers aimed to repurpose local prenatal screening data to identify genetic variants associated with colorectal cancer, focusing on genes associated with Lynch syndrome as the most common germline mutations associated with the development of CRC. [ 4 ] A recently published joinpoint analysis of local CRC trends showed only slight improvement in reduced mortality (0.9%) in the follow-up period from 2001 to 2018 compared to the previous period from 1971 to 2001, limited to the age group from 29 to 45 years old [ 5 ]. Due to the lack of improvement in CRC prevalence, the identification of possible driver mechanisms can help to elucidate the high incidence as well as mortality of CRC in Slovakia, as the underlying cause of this problem is still unclear, with a limited number of regional studies being conducted [ 4 ].…”