2022
DOI: 10.1038/s41746-022-00694-7
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Health digital twins as tools for precision medicine: Considerations for computation, implementation, and regulation

Abstract: Health digital twins are defined as virtual representations (“digital twin”) of patients (“physical twin”) that are generated from multimodal patient data, population data, and real-time updates on patient and environmental variables. With appropriate use, HDTs can model random perturbations on the digital twin to gain insight into the expected behavior of the physical twin—offering groundbreaking applications in precision medicine, clinical trials, and public health. Main considerations for translating HDT re… Show more

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Cited by 71 publications
(49 citation statements)
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“…2) [9 ▪ ]. Digital twin systems go beyond classic remote patient monitoring by adding data-driven artificial intelligence systems and rapid data synchronization between the patient and their virtual counterpart, allowing to obtain a live meaningful representation of the patient, which can be used to monitor, diagnose or adjust treatment [10 ▪▪ ]. In asthma, technological advances concern both sensors (connected objects), computer models (models based on machine learning) and actuators (patient support systems).…”
Section: Digital Twins For Patients With Asthmamentioning
confidence: 99%
“…2) [9 ▪ ]. Digital twin systems go beyond classic remote patient monitoring by adding data-driven artificial intelligence systems and rapid data synchronization between the patient and their virtual counterpart, allowing to obtain a live meaningful representation of the patient, which can be used to monitor, diagnose or adjust treatment [10 ▪▪ ]. In asthma, technological advances concern both sensors (connected objects), computer models (models based on machine learning) and actuators (patient support systems).…”
Section: Digital Twins For Patients With Asthmamentioning
confidence: 99%
“…[142][143][144][145] Digital twins are mainly targeted at engineering systems but can also be applied to various fields, such as medical and information systems that perform critical decisions in surgical or physical systems. [146,147] Digital twins can efficiently derive diagnoses and prognoses for each patient and ) Schematic illustrations of a face-mediated human-robot interaction system. The haptic response is measured through tactile sensors, and the measured force is rendered as a facial expression.…”
Section: Digital Twins For Diagnostics and Therapeuticsmentioning
confidence: 99%
“…The information flow is bidirectional—the patient receives the digital intervention through OCE and provides information for the DHI operations. All available relevant data, for example, medical data, health data, connections, digital preferences, and data for health can be centrally collected and integrated to form a digital twin [ 49 , 50 ]. Digital twin is a digital representation of the individual whose data it is based on.…”
Section: Omnichannel Engagement For Dhi-led Behavioral Changementioning
confidence: 99%