Health beneficial and pharmacological properties of p-cymene

Balahbib, Abdelaali; Omari, Nasreddine El; Hachlafi, Naoufal El; Lakhdar, Fatima; Menyiy, Naoual El; Salhi, Najoua; Mrabti, Hanae Naceiri; Bakrim, Saad; Zengin, Gökhan; Bouyahya, Abdelhakim

doi:10.1016/j.fct.2021.112259

Cited by 92 publications

(55 citation statements)

References 147 publications

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“…In the current work, it was also proved that O. vulgare essential oil provides the strongest antimicrobial activity against S. aureus, among all the different essential oils analyzed. The strong antimicrobial activity is also related to the high content of p-cymene, a compound that has been shown to have many biological actions such as anti-inflammatory, anticancer, antimicrobial and antioxidant effects, but is not yet validated for its safe use against all these diseases [33]. Concerning the main allergen content, it was proved that the current samples did not contain linalool and citral, but they possessed a small content of limonene (about 0.2% w/w).…”

Section: Discussionmentioning

confidence: 99%

Chemical Composition of Essential Oils of Aromatic and Medicinal Herbs Cultivated in Greece—Benefits and Drawbacks

Pasias¹,

Ntakoulas

Raptopoulou³

et al. 2021

Foods

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The current study investigated and determined the major compounds of six essential oils derived from different plant species cultivated in Greece (Lavandula angustifolia, Origanum vulgare, Pistacia lentiscus var. chia, Citrus reticulata, Citrus limon and Crithmum maritimum). The results proved that all these essential oils have a high potential for use as food preservatives, since among the compounds determined were sabinene, b-myrcene, a-pinene, carvacrol and limonene, all of which were responsible for the strong antimicrobial activity against Staphylococcus aureus. However, the amounts of some compounds, such as linalool and citral, were at high levels, and this can be a danger for some sensitive population groups due to allergic reactions. The essential oil compounds which were identified using GC-MS and quantified through GC-FID represented more than 95% of the total essential oils of the investigated plant species. Finally, all essential oils provided high phenolic content.

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Section: Discussionmentioning

confidence: 99%

Chemical Composition of Essential Oils of Aromatic and Medicinal Herbs Cultivated in Greece—Benefits and Drawbacks

Pasias¹,

Ntakoulas

Raptopoulou³

et al. 2021

Foods

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show abstract

“…Therefore, researchers have been searching for alternatives to conventional antibiotics. Within this context, natural substances, particularly those extracted from medicinal plants, constitute a source of drugs against various pathologies, including diabetes, cancer, inflammation, and pathologies linked to stress and microbial infections [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 ]. The antibacterial activity of these natural products is linked to different mechanisms of action, such as the increase in membrane permeability, the decrease in membrane integrity, and the disruption of efflux pumps [ 10 , 13 , 18 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

Mechanisms, Anti-Quorum-Sensing Actions, and Clinical Trials of Medicinal Plant Bioactive Compounds against Bacteria: A Comprehensive Review

et al. 2022

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Bacterial strains have developed an ability to resist antibiotics via numerous mechanisms. Recently, researchers conducted several studies to identify natural bioactive compounds, particularly secondary metabolites of medicinal plants, such as terpenoids, flavonoids, and phenolic acids, as antibacterial agents. These molecules exert several mechanisms of action at different structural, cellular, and molecular levels, which could make them candidates or lead compounds for developing natural antibiotics. Research findings revealed that these bioactive compounds can inhibit the synthesis of DNA and proteins, block oxidative respiration, increase membrane permeability, and decrease membrane integrity. Furthermore, recent investigations showed that some bacterial strains resist these different mechanisms of antibacterial agents. Researchers demonstrated that this resistance to antibiotics is linked to a microbial cell-to-cell communication system called quorum sensing (QS). Consequently, inhibition of QS or quorum quenching is a promising strategy to not only overcome the resistance problems but also to treat infections. In this respect, various bioactive molecules, including terpenoids, flavonoids, and phenolic acids, exhibit numerous anti-QS mechanisms via the inhibition of auto-inducer releases, sequestration of QS-mediated molecules, and deregulation of QS gene expression. However, clinical applications of these molecules have not been fully covered, which limits their use against infectious diseases. Accordingly, the aim of the present work was to discuss the role of the QS system in bacteria and its involvement in virulence and resistance to antibiotics. In addition, the present review summarizes the most recent and relevant literature pertaining to the anti-quorum sensing of secondary metabolites and its relationship to antibacterial activity.

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“…Similar to several other bioactives which showed promising anticancer properties [ 87 , 88 , 89 , 90 , 91 , 92 , 93 ], carvone has also been studied for its anticancer properties. Indeed, several in vitro investigations based on cell culture tests showed that this compound exhibits antiproliferative effects against various cancer cell lines.…”

Section: Resultsmentioning

confidence: 99%

Health Benefits and Pharmacological Properties of Carvone

et al. 2021

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Carvone is a monoterpene ketone contained in the essential oils of several aromatic and medicinal plants of the Lamiaceae and Asteraceae families. From aromatic plants, this monoterpene is secreted at different concentrations depending on the species, the parts used, and the extraction methods. Currently, pharmacological investigations showed that carvone exhibits multiple pharmacological properties such as antibacterial, antifungal, antiparasitic, antineuraminidase, antioxidant, anti-inflammatory, and anticancer activities. These studies were carried out in vitro and in vivo and involved a great deal of knowledge on the mechanisms of action. Indeed, the antimicrobial effects are related to the action of carvone on the cell membrane and to ultrastructural changes, while the anti-inflammatory, antidiabetic, and anticancer effects involve the action on cellular and molecular targets such as inducing of apoptosis, autophagy, and senescence. With its multiple mechanisms, carvone can be considered as natural compounds to develop therapeutic drugs. However, other investigations regarding its precise mechanisms of action as well as its acute and chronic toxicities are needed to validate its applications. Therefore, this review discusses the principal studies investigating the pharmacological properties of carvone, and the mechanism of action underlying some of these properties. Moreover, further investigations of major pharmacodynamic and pharmacokinetic studies were also suggested.

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Health beneficial and pharmacological properties of p-cymene

Cited by 92 publications

References 147 publications

Chemical Composition of Essential Oils of Aromatic and Medicinal Herbs Cultivated in Greece—Benefits and Drawbacks

Chemical Composition of Essential Oils of Aromatic and Medicinal Herbs Cultivated in Greece—Benefits and Drawbacks

Mechanisms, Anti-Quorum-Sensing Actions, and Clinical Trials of Medicinal Plant Bioactive Compounds against Bacteria: A Comprehensive Review

Health Benefits and Pharmacological Properties of Carvone

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