Health‐associated reference values for arginine, asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA) measured with high‐performance liquid chromatography

Hov, Gunhild Garmo; Sagen, Erling; Bigonah, Arash; Åsberg, Arne

doi:10.1080/00365510701429836

Cited by 35 publications

(28 citation statements)

References 27 publications

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“…Compared to the healthy general population, mean SDMA levels were elevated in our RTR cohort (31,32). Our SDMA values were in concert with a review by Fleck et al (33) demonstrating high levels of dimethylarginines in endstage renal disease patients, SMDA levels decreasing after renal transplantation, though not reaching reference values for healthy subjects.…”

Section: Discussionsupporting

confidence: 84%

Symmetric Dimethylarginine as Predictor of Graft Loss and All-Cause Mortality in Renal Transplant Recipients.

et al. 2014

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Background. Elevated symmetric dimethylarginine (SDMA) has been shown to predict cardiovascular events and all cause mortality in diverse populations. The potential role of SDMA as a risk marker in renal transplant recipients (RTR) has not been investigated. Methods. We analyzed SDMA in the placebo arm of the Assessment of Lescol in Renal Transplantation study, a randomized controlled trial of fluvastatin in RTR. Mean follow-up was 5.1 years. Patients were grouped into quartiles based on SDMA levels at study inclusion. Relationships between SDMA and traditional risk factors for graft function and all-cause mortality were analyzed in 925 RTR using univariate and multivariate survival analyses.Results. In univariate analysis, SDMA was significantly associated with renal graft loss, all-cause death, and major cardiovascular events. After adjustment for established risk factors including estimated glomerular filtration rate, an elevated SDMA-level (4th quartile, 91.38 Kmol/L) was associated with renal graft loss; hazard ratio (HR), 5.51; 95% confidence interval (CI), 1.95Y15.57; P=0.001, compared to the 1st quartile. Similarly, SDMA in the 4th quartile was independently associated with all-cause mortality (HR, 4.56; 95% CI, 2.15Y9.71; PG0.001), and there was a strong borderline significant trend for an association with cardiovascular mortality (HR, 2.86; 95% CI, 0.99Y8.21; P=0.051). Conclusion. In stable RTR, an elevated SDMA level is independently associated with increased risk of all-cause mortality and renal graft loss.

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Section: Discussionsupporting

confidence: 84%

Symmetric Dimethylarginine as Predictor of Graft Loss and All-Cause Mortality in Renal Transplant Recipients.

et al. 2014

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“…Although ADMA values of both ex-ELBW and C were in the previously reported normal reference range (0.380-0.730 μmol/L for females below the age of 45 years and 0.410-0.790 μmol/L for males of all ages), a statistically significant difference (ELBW vs C) was detected for ADMA blood levels (0.606 + 0.095 vs 0.562 + 0.101 μmol/L, p b 0.05) [18].…”

Section: Resultssupporting

confidence: 63%

Could ADMA levels in young adults born preterm predict an early endothelial dysfunction?

Bassareo¹,

Puddu²,

Flore³

et al. 2012

International Journal of Cardiology

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“…Compared to the healthy general population, mean SDMA levels were elevated in our RTR cohort ( 31, 32 ). Our SDMA values were in concert with a review by Fleck et al ( 33 ) demonstrating high levels of dimethylarginines in end-stage renal disease patients, SMDA levels decreasing after renal transplantation, though not reaching reference values for healthy subjects.…”

Section: Discussionmentioning

confidence: 52%

Symmetric Dimethylarginine as Predictor of Graft loss and All-Cause Mortality in Renal Transplant Recipients

et al. 2014

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Health‐associated reference values for arginine, asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA) measured with high‐performance liquid chromatography

Abstract: Age affects p-ADMA in healthy women, but not in men.

Cited by 35 publications

References 27 publications

Symmetric Dimethylarginine as Predictor of Graft Loss and All-Cause Mortality in Renal Transplant Recipients.

Symmetric Dimethylarginine as Predictor of Graft Loss and All-Cause Mortality in Renal Transplant Recipients.

Could ADMA levels in young adults born preterm predict an early endothelial dysfunction?

Symmetric Dimethylarginine as Predictor of Graft loss and All-Cause Mortality in Renal Transplant Recipients

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