Could ADMA levels in young adults born preterm predict an early endothelial dysfunction?

Bassareo, Pier Paolo; Puddu, Melania; Flore, Giovanna; Deidda, Martino; Manconi, Ettore; Melis, Alessandro; Fanos, Vassilios; Mercuro, Giuseppe

doi:10.1016/j.ijcard.2011.02.069

Cited by 21 publications

(18 citation statements)

References 27 publications

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“…However, in another study, ADMA levels were significantly lower in SGA pregnancies than in controls, in the first (11-14 weeks), second (20-24 weeks) and third trimesters (28-35 weeks) (Rizos et al 2012). ADMA levels were also lower in young adults born preterm at extremely low birth weight compared with healthy adults born at term (Bassareo et al 2012). …”

Section: Intrauterine Fetal Growth Restriction and The Arginine/ No Pmentioning

confidence: 87%

The role of arginine, homoarginine and nitric oxide in pregnancy

2015

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Normal pregnancy leads to profound maternal hemodynamic changes, including increased blood volume and vasodilatation. Several vasodilator mediators are implicated, including prostaglandins, carbon monoxide and nitric oxide (NO). Pre-eclampsia (PE) affects 3-10 % of pregnancies and is associated with increased maternal and perinatal morbidity and mortality. Around 8 % of pregnancies are complicated by intra-uterine growth restriction (IUGR), also associated with increased perinatal mortality and morbidity. PE and IUGR often co-exist. NO is essential for the formation of healthy endothelium, and in pregnancy promotes endovascular invasion by the cytotrophoblast. As interstitial trophoblasts invade the maternal spiral arteries in the uterine wall, they produce NO which acts on artery walls to create a low-resistance, high-caliber uteroplacental unit. If this process fails, the result is a high-resistance uteroplacental circulation. The hypoperfused and ischemic placenta releases antiangiogenic factors which mediate generalized endothelial dysfunction, oxidative stress and inflammatory mediators. It is these mediators that are implicated in both the fetal and maternal syndromes of PE and IUGR. Studies of NO and its modulator amino acids, including the precursors arginine and homoarginine and the NO synthesis inhibitor asymmetric dimethylarginine (ADMA), have investigated their role in both normal and pathological pregnancies. Many studies of PE (and, to a lesser extent, IUGR) have investigated maternal circulating ADMA, arginine and homoarginine levels. This article reviews and discusses the role of these amino acids in pregnancy. The results have shed some light on their role in these pathologies, but some of the findings have been conflicting and more research is needed. Nevertheless, therapeutic interventions that manipulate these guanidine-amino acids and their interactions hold real promise for the management of pregnancies complicated by PE and/or IUGR, and the results of ongoing studies are eagerly awaited.

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Section: Intrauterine Fetal Growth Restriction and The Arginine/ No Pmentioning

confidence: 87%

The role of arginine, homoarginine and nitric oxide in pregnancy

2015

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“…As pioneer in this field,2 3 our research group had already demonstrated a similar alteration in a group of young adults who were born extremely preterm (birth weight <1 kg; gestational age <28 weeks). In this study group, both systolic blood pressure and arterial stiffness measured by means of a previously validated method (flow mediated dilation) appear to be increased in comparison with healthy controls born at term.…”

mentioning

confidence: 79%

“…Furthermore, in our sample the underlying alteration responsible for these findings is the high level of asymmetric dimethylarginine,2 an endogenous strong inhibitor of nitric oxide synthesis. Renal excretion of asymmetric dimethylarginine also appears to be inversely related to intrauterine growth restriction4 ( expressed as birth weight).…”

mentioning

confidence: 86%

Response to ‘In adolescence, extreme prematurity is associated with significant changes in the microvasculature, elevated blood pressure and increased carotid intima-media thickness’

2015

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“…Moreover, it has been shown that ADMA is an independent predictor of progression to the ESRD and death in patients with chronic kidney disease [5,15,21]. Indeed, the initial high blood levels of this substance are associated with the future development of adverse cardiovascular events and cardiac death [6]. What is interesting to note, our results might have practical implications, because they suggest that an increase in ADMA levels is a marker of cardiovascular events and in particular is correlated with adrenaline level, having predictive value of mortality among HD patients.…”

Section: Discussionmentioning

confidence: 99%

Plasma levels of catecholamines and asymmetric dimethylarginine levels as predictive values of mortality among hemodialysis patients

Dziedzic

Orłowska²,

Gaweł

et al. 2014

Current Issues in Pharmacy and Medical Sciences

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The aim of the study was to assess plasma concentration of catecholamines and asymmetric dimethyl arginine levels and a possible relationship to predict the mortality rates among hemodialysis patients. The study population comprised 27 subjects, aged 65-70 years. Each patient underwent dialysis thrice a week. Furthermore, the median duration of hemodialysis was 3.5 years. Based on the conducted research, it can be concluded that the concentrations of adrenaline and the level of asymmetric dimethylarginine have predictive value of mortality among hemodialysis patients. Of note, lowering plasma asymmetric dimethylarginine concentration may represent therapeutic target for prevention of progressive renal damage.

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Could ADMA levels in young adults born preterm predict an early endothelial dysfunction?

Cited by 21 publications

References 27 publications

The role of arginine, homoarginine and nitric oxide in pregnancy

The role of arginine, homoarginine and nitric oxide in pregnancy

Response to ‘In adolescence, extreme prematurity is associated with significant changes in the microvasculature, elevated blood pressure and increased carotid intima-media thickness’

Plasma levels of catecholamines and asymmetric dimethylarginine levels as predictive values of mortality among hemodialysis patients

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