Healing response to various forms of human demineralized bone matrix in athymic rat cranial defects

Chesmel, K.; Branger, Judith; Wertheim, Heiman; Scarborough, Nelson

doi:10.1016/s0278-2391(98)90015-5

Cited by 63 publications

(46 citation statements)

References 15 publications

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“…As early as 1889, Senn et al 2 reported using demineralized zenograft bone to fill defects in the tibia and femur. Chesmel 3 showed demineralized bone performs as well as autograft bone in filling many bone defects. Also, demineralized bone has been used as plates for orbital and craniofacial reconstruction.…”

Section: Introductionmentioning

confidence: 99%

Characterization of the mechanical properties of demineralized bone

Summitt

Reisinger

2003

J Biomedical Materials Res

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Demineralized bone has had limited use as a medical implant, although, recently Jackson et al. (Am J Sports Med 1996;24(4):405-414) examined using demineralized bone as an anterior cruciate ligament (ACL) replacement and found that within 1 year the demineralized bone had remodeled from a haversian system (bone-like) into a ligament-like structure. Little research has been done to characterize the mechanical properties of demineralized bone and examine its potential as a ligament replacement. This research examined the mechanical properties of demineralized bone as a function of acid saturation time and methods of processing and sterilization using specimens from various anatomic locations. Bone specimens were manufactured from the tibia, metatarsus, femur, radius, and humerus of bovine bone. Tensile strength, strain, and modulus of elasticity were examined for various acid saturation times and sterilization treatments. Additionally, viscoelastic properties, creep and stress relaxation, and fatigue properties were examined. The findings indicate that completely demineralized bone has mechanical properties similar to the ACL and, therefore, has increased likelihood for success in ACL reconstruction surgery.

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Section: Introductionmentioning

confidence: 99%

Characterization of the mechanical properties of demineralized bone

Summitt

Reisinger

2003

J Biomedical Materials Res

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“…These materials are useful in augmenting the healing of bony defects caused by traumatic injury, tumor removal, abnormal skeletal development, cyst removal and prosthetic loosening. DBM has also been shown to aid in the stimulation of an osteoinductive response allowing for improved bone growth and fusion (Chesmel et al 1998;Kado et al 1996;Urist and Dowell 1968). Allogenic DBM possesses osteoinductive properties and may serve as an ideal drug delivery device in the prophylactic treatment in a variety of different anatomical locations (Glowacki et al 1981;Sassard et al 2000;Tiedeman et al 1995).…”

Section: Introductionmentioning

confidence: 99%

Local antibiotic delivery with demineralized bone matrix

et al. 2011

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A method of care for these infected nonunions is prolonged intravenous systemic antibiotic treatment and implantation of methyl methacrylate antibiotic carrier beads to delivery high local doses of antibiotics. This method requires a second surgery to remove the beads once the infection has cleared. Recent studies have investigated the use of biodegradable materials that have been impregnated with antibiotics as tools to treat bone infections. In the present study, human demineralized bone matrix (DBM) was investigated for its ability to be loaded with an antibiotic. The data presented herein demonstrates that this osteoinductive and biodegradable material can be loaded with gentamicin and release clinically relevant levels of the drug for at least 13 days in vitro. This study also demonstrates that the antibiotic loaded onto the graft has no adverse effects on the osteoinductive nature of the DBM as measured in vitro and in vivo. This bone void filler may represent a promising option for local antibiotic delivery in orthopedic applications.

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“…The second fact is that these proteins are highly conserved among the different mammal species (6). The amino acidic sequence homology (the percentage of identical amino acids) is so high -when not complete-that the DBM of one species is stimulating even when grafted in an individual of another species (2,4,10).…”

Section: Introductionmentioning

confidence: 99%