Healing property of the<i>Piper</i>betel phenol, allylpyrocatechol against indomethacin-induced stomach ulceration and mechanism of action

Bhattacharya, Saurav; Banerjee, Debashish; Bauri, AK; Chattopadhyay, Subrata; Sk, Bhattacharya

doi:10.3748/wjg.v13.i27.3705

Cited by 68 publications

(54 citation statements)

References 27 publications

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“…However, the presence of all these compounds depends on the region where it grows; the oil has been used in respiratory troubles, cataract, and also as an antiseptic [76]. Its antiulcerogenic [77,78] activity has been reported. One of its active components, the allylpyrocatechol, shows the best antiulcer activity mainly by modulation of arginase metabolism and shift of cytokine balance [79].…”

Section: Piper Betlementioning

confidence: 99%

Herbal Remedy: An Alternate Therapy of Nonsteroidal Anti-Inflammatory Drug Induced Gastric Ulcer Healing

Chatterjee

Bandyopadhyay

2014

Ulcers

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Nonsteroidal anti-inflammatory drugs (NSAIDs) are one of the most commonly used therapeutic drug groups used worldwide for curing an array of health problems like pain, inflammation, cardiovascular complications, and many other diseases, but they may cause different side effects including gastroduodenal disorders. So, there is a growing interest and need to search for nontoxic, antiulcer formulations from medicinal plants to treat NSAIDs induced gastric ulcer. Extensive research has reported on many natural plants like Camellia sinensis, Phyllanthus emblica, Myristica malabarica, Piper betle, Picrorhiza kurroa, and so forth, and their active constituents reduced NSAIDs induced gastric ulcer via their antioxidative as well as immunomodulatory activity. Therefore, use of herbal formulations in daily life may prevent NSAIDs induced gastric ulceration and other side effects.

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Section: Piper Betlementioning

confidence: 99%

Herbal Remedy: An Alternate Therapy of Nonsteroidal Anti-Inflammatory Drug Induced Gastric Ulcer Healing

Chatterjee

Bandyopadhyay

2014

Ulcers

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“…As efficient antioxidants and stimulators for prostaglandin (PG) synthesis and angiogenesis, many phenolics are known to show antiulcerogenic activities (Bhattacharya et al, 2007). However, reports on the gastroprotective property of the hydroxystilbenoids are scarce.…”

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confidence: 99%

Improved Antiulcer and Anticancer Properties of a trans-Resveratrol Analog in Mice

Guha¹,

Dey²,

Sarkar³

et al. 2008

J Pharmacol Exp Ther

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Despite its potential, use of trans-resveratrol as an anticancer drug is severely constrained because of its tendency to prolong gastric ulceration. We found that in addition to delaying ulcer healing, trans-resveratrol also aggravated acute gastric ulceration induced by the nonsteroidal anti-inflammatory drugs by reducing the synthesis of prostaglandin (PG) E 2 via a specific inhibition of cyclooxygenase (COX)-1 that also hampered angiogenesis. However, for the first time, we showed that the 3Ј-5Ј-hydroxylated congener [(E)-HST-1] of trans-resveratrol, synthesized in multigram scale, exerted potential chemotherapeutic property but was nonulcerogenic in nature, rather moderately accelerated healing of indomethacin-induced gastric ulceration. HST-1 did not suppress COX-1, COX-2 expression, and PGE 2 synthesis but reduced the level of inflammatory myeloperoxidase (MPO) activity. The healing was augmented primarily through the nitric oxide synthase (NOS)-dependent pathway. HST-1 treatment induced endothelial NOS (eNOS) expression and reduced inducible NOS (iNOS), resulting in increased eNOS/iNOS ratio. The selective iNOS inhibitor [L-N 6 -(1-iminoethyl) lysine hydrochloride] and nonselective NOS inhibitor (N -nitro-L-arginine methyl ester) treatment revealed that eNOS could be the probable molecular switch to accelerate the indomethacin-induced ulcer healing in HST-1-treated mice. Furthermore, the anticancer effect of HST-1 on U937 and K562 leukemia cell lines was found to be significantly better than that of trans-resveratrol. Overall, these established HST-1 as a potentially better anticancer compound than trans-resveratrol, considering it is devoid of any ulcerogenic side effects. In conclusion, for the first time, we showed that a novel analog of trans-resveratrol, HST-1, was devoid of ulcerogenic adversative effects of trans-resveratrol but retained potentially better anticancer property.

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“…Se ha demostrado el efecto cicatrizante del extracto etanólico de Piper angustifolium al ser usado en heridas inducidas a ratones (25) , así como un efecto protector al usar un jabón conteniendo extracto etanólico de hojas de la mencionada planta sobre piel sana de conejos (26) . Asimismo, se ha estudiado la actividad antiulcerosa de un flavonoide nuevo aislado 2"-0-ramnosil 4"-0-metil-vitexina de las hojas de Piper ossanum, mediante extracción con alcohol etílico al 70%, la solución de flavonoides mostró una evidente actividad antiulcerosa expresada por el índice de lesión y el porcentaje de inhibición de formación de lesiones, por lo que se concluyó que ese flavonoide actuó como un antiulceroso similar al sucralfato (6) .…”

Section: Discussionunclassified

Efecto gastroprotector y antisecretor de un fitofármaco de hojas de matico (Piper aduncum)

Arroyo

Bonilla

Moreno-Exebio

et al. 2014

Rev Peru Med Exp Salud Publica

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Objetivos. Determinar el efecto gastroprotector y antisecretor del extracto etanólico de las hojas de matico (Piper aduncum) en modelos animales. Materiales y métodos. Para la evaluación del efecto gastroprotector se utilizó 220 ratones de la cepa Balb C57, los cuales fueron aleatorizados en 22 grupos de diez animales, a los cuales se les indujo la formación de úlceras gástricas con indometacina, la gastroprotección se determinó a través de tres aspectos: inflamación, número de bandas hemorrágicas y número de úlceras. Para evaluar el efecto antisecretor se utilizó 64 ratas albinas machos Holtzman, los cuales fueron aleatorizados en ocho grupos de ocho animales, un control y siete grupos de tratamiento con un nivel de dosis de los extractos y dos niveles de dosis en los fitofármacos; la antisecreción se realizó con el ensayo de ligazón pilórica. Resultados. Para la gastroprotección, los extractos de diclorometano, cloroformo, hexano y metanol, lograron una disminución de la inflamación de más del 66% (p<0,05); el extracto etanólico presenta una actividad de 100% para disminuir el número de bandas hemorrágicas (p<0,05); el extracto clorofórmico presenta una actividad antiulcerosa de 75% (p<0,05). Respecto a la antisecreción, el fitofármaco en cápsulas conteniendo el extracto etanólico logró un 72% de reducción del volumen de la secreción gástrica (p<0,01) y un incremento del pH en 104,3% (p<0,01). Conclusiones. En condiciones experimentales los extractos etanólico, sus fracciones y su fitofármaco son gastroprotectores en ratones y antisecretores en ratas. Palabras clave: Matico; Plantas medicinales; Fitoterapia; Extractos vegetales (fuente: DeCS BIREME). GASTROPROTECTIVE AND ANTISECRETORY EFFECT OF A PHYTOCHEMICAL MADE FROM MATICO LEAVES (Piper aduncum)ABSTRACT Objectives. To determine the gastroprotective and antisecretory effect of ethanol extract from matico leaves (Piper aduncum) in animal models. Materials and methods. To evaluate the gastroprotective effect, 220 mice of the Balb C57 strain were used. They were randomized in 22 groups of ten animals each, in which the formation of gastric ulcers was induced with indomethacin. Gastroprotection was determined by evaluating three aspects: inflammation, number of hemorrhagic shocks and number of ulcers. To evaluate the antisecretory effect, 64 white male Holtzman rats were used, which were randomized in eight groups of eight animals, one control and seven groups of treatment with one extract dose level and two phytochemical dose levels. Antisecretion was obtained through the pylorus ligation. Results. Regarding gastroprotection, dichloromethane, chloroform, hexane and methanol extracts decreased inflammation to over 66% (p<0,05). The ethanolic extract shows 100% activity in reducing the number of hemorrhagic bands (p<0,05). The chloroform extract shows antiulcer activity at 75% (p<0,05). In terms of antisecretion, the phytochemical in capsules containing the ethanolic extract achieved 72% reduction of the gastric secretion volume (p<0,01) and 104,3% (p<0,01) PH i...

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Healing property of thePiperbetel phenol, allylpyrocatechol against indomethacin-induced stomach ulceration and mechanism of action

Abstract: APC can protect indomethacin-induced gastric ulceration due to its antioxidative and mucin protecting properties.

Cited by 68 publications

References 27 publications

Herbal Remedy: An Alternate Therapy of Nonsteroidal Anti-Inflammatory Drug Induced Gastric Ulcer Healing

Herbal Remedy: An Alternate Therapy of Nonsteroidal Anti-Inflammatory Drug Induced Gastric Ulcer Healing

Improved Antiulcer and Anticancer Properties of a trans-Resveratrol Analog in Mice

Efecto gastroprotector y antisecretor de un fitofármaco de hojas de matico (Piper aduncum)

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