Healing of normal and osteopenic bone with titanium implant and low-level laser therapy (GaAlAs): a histomorphometric study in rats

Abstract

The study investigates the influence of low-level laser therapy (LLLT) on bone healing in the femur of osteopenic and normal rats with titanium implants. Ovariectomy and control group were randomly submitted to LLLT, which was applied by gallium-aluminum-arsenium (GaAlAs) laser at the surgical site before and after placing the implant, for seven times. Histomorphometric and statistical analysis were performed. Most irradiated groups showed higher values than the nonirradiated groups. The GaAlAs infrared diode laser may improve the osseointegration process in osteopenic and normal bone, particularly based on its effects in the initial phase of bone formation.

The efficacy of low-level 940 nm laser therapy with different energy intensities on bone healing

“…LLLT also has various effects in bone tissue according to the application parameters, such as the type of laser used, energy density (J/cm 2 ), time and frequency of irradiation, and wavelength, which can contribute effectively to the stimulation of bone cells by increasing the osteoblastic activity at the defect area. 2,14,22 Thus, the biomodulatory effects of laser irradiation seem to be dose dependent. 2 In addition, the method of application can also influence the biostimulatory effect of the laser on bone cells.…”

“…There are some promising study results on bone healing related to LLLT application with higher doses such as 112 J/cm 2 [1], 300 J/cm. 2,12 However, some studies have indicated that low-dose applications including 4.8 J/cm 2 and 16 J/cm 2 energy intensities are effective for the biostimulation of bone tissue.…”

“…1 LLLT has been shown to be effective for biostimulating bone cells in both in vivo 2,3 and in vitro 4,5 studies. The widely accepted hypothesis regarding the mechanism of LLLT is that the laser energy activates cytochromes in the cell, resulting in the acceleration of cellular activity, increased ATP and ALP concentrations and the release of calcium.…”

Influence of low-level laser on dental implant sites: A literature review

“…8,9,19,20 Numerous studies have identified morphological changes in the peri-implant region based on histomorphometric analyses. [4][5][6][7]12,21,22 Other researches have used immunohistochemical analyses to verify the expression of biomarkers in active bone remodeling and the metabolic activity of bone after irradiation with LLLT.…”

“…11 he biostimulation repair triggered by laser radiation is subject to a combination of parameters that comprise application protocols. 12 In addition, the efect is dependent on the dose irradiated, the method of application and the number of sessions. Together, these parameters determine the efectiveness of osteogenic cell stimulation and proliferation.…”