Healing following tooth extraction in cyclosporine-fed rats

Effect of cyclosporine‐A on orthodontic tooth movement in rats

“…2). This measurement was made by superimposing the image with a calibrated micrometer disc under ×200 magnification, as in previous studies (10).…”

“…In the alveolar process, a pattern of osteopenia was observed in animals that received CsA (8, 9). Studies also suggest that the use of CsA may influence both alveolar bone healing in tooth‐extraction sockets (10), as well as around titanium implants (11). In our previous study, we found that an increased interincisor diastema appeared after the overgrowth of the papilla in animals taking CsA.…”

Expression and bioactivities of endothelin‐1 in gingiva during cyclosporine A treatment

“…Maxillary edentulous ridges were established in 32 5‐week‐old male Sprague–Dawley rats weighing 120–150 g, as previously described (18,19). In brief, all right maxillary molars were extracted under general anesthesia with ketamine.…”

Alendronate therapy in cyclosporine‐induced alveolar bone loss in rats

“…Bone loss is a clinically important problem affecting from 6 to 15% of all patients in the first year after organ transplantation (6,7); however, there are no epidemiological data on alveolar bone loss in cyclosporine A‐treated humans. On the other hand, studies in experimental animals have suggested that the use of cyclosporine A may influence bone healing around titanium implants (8), as well as the healing of both alveolar mucosa and bone in tooth‐extraction sockets (9,10).…”