Effect of cyclosporine‐A on orthodontic tooth movement in rats

Ry, Chen; Mm, Fu; Yk, Chih; Ch, Gau; Cy, Chiang; Nieh, Shin; Yd, Hsieh; E, Fu

doi:10.1111/j.1601-6343.2011.01528.x

Cited by 5 publications

(4 citation statements)

References 48 publications

(52 reference statements)

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“…Urinary phosphate excretion in CsA-treated rats was increased as compared to control values, although plasma phosphate level did not significantly change, and empagliflozin administration in CsA-treated rats blunted the increase in urinary phosphate excretion and reduced plasma phosphate levels. In addition, plasma Tracp-5b levels, used a marker of osteoclast activity, were increased in CsA-treated rats [ 44 , 45 ] as compared to control rats and showed a slight decrease in CsA + empagliflozin-treated rats. Although the investigation of bone metabolism is outside the aims of our study, these data strongly suggest that SGLT2 inhibitors have a role also in mineral homeostasis [ 43 ].…”

Section: Discussionmentioning

confidence: 99%

Sodium-glucose cotransporter 2 inhibition prevents renal fibrosis in cyclosporine nephropathy

et al. 2021

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Aims Sodium-glucose cotransporter 2 (SGLT2) inhibitors, a new class of antidiabetic drugs, are nephroprotective in case of diabetes, but whether a similar beneficial effect may be detectable also in case of chronic non-diabetic kidney diseases remains still unknown. The aim of this study was to evaluate the effects of empagliflozin, a SGLT-2 inhibitor, on the progression of cyclosporine nephropathy, in the absence of diabetes. Methods Sprague Dawley rats (n = 27) have been fed with low-salt diet starting 10 days before the beginning and finished at the end of the experimental period. Cyclosporine-A (CsA, 15 mg/kg/day, intraperitoneal injection, n = 8) and CsA plus empagliflozin (Empa, 10 mg/kg/day, per os, n = 7) were administered for 4 weeks. The control groups were treated with placebo (Control, n = 7) or empagliflozin (Control + Empa, n = 5). Blood pressure (plethysmographic method) was measured at the beginning and at the end of the experimental period. At the end of the experimental protocol, the kidneys were excised for histomorphometric analysis of renal fibrosis and for immunohistochemical evaluation of inflammatory infiltrates (monocytes/macrophages), type I and type IV collagen expression, and tyrosine hydroxylase expression, used as marker of sympathetic nerve activity. Results CsA-treated rats showed a significant increase (p < 0.01) in blood pressure, which was reduced by administration of empagliflozin (p < 0.05). CsA administration caused an increase in glomerular and tubulo-interstitial fibrosis (p < 0.05), renal inflammatory infiltrates (p < 0.05), type I and type IV collagen expression (p < 0.01), and tyrosine hydroxylase expression (p < 0.01) as compared to the control rats and control + Empa-treated rats. Treatment with empagliflozin in CsA-treated rats reduced glomerular (p < 0.01) and tubulo-interstitial fibrosis (p < 0.05), type I and type IV collagen expression (p < 0.01), inflammatory cell infiltration (p < 0.01) and tyrosine hydroxylase expression (p < 0.05), as compared to rats treated with CsA. Conclusion Empagliflozin administration caused a reduction in blood pressure in CsA-treated rats and showed a protective effect on CsA nephropathy by decreasing renal fibrosis, type I and type IV collagen expression, macrophage infiltration and tyrosine hydroxylase expression. These data suggest that empagliflozin promotes nephroprotection also in non-diabetic kidney disease.

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Section: Discussionmentioning

confidence: 99%

Sodium-glucose cotransporter 2 inhibition prevents renal fibrosis in cyclosporine nephropathy

et al. 2021

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“…95 The osteopenia and the increased osteoclastic activity could be the underlying factors. 96 In steroid study, acute corticosteroid ingestion reduces bone turnover. Therefore, orthodontic treatment might best be postponed until a time the patient is free of the drug.…”

Section: Discussionmentioning

confidence: 99%

“…Corticosteroids are commonly used to treatmany different diseases because of their antiinflammatoryeffect. 75 A study was done to investigate the effect of different courses of glucocorticosteroid treatment on orthodontically induced root resorption.Rats were divided into three groups: control, acute and chronic. Acute and chronic groups received corticosteroid treatment (5 mg/kg/ day of methylprednisolone) for 3 and seven weeks, respectively, while no pharmacological treatment was performed in the control group.…”

Section: Resorption Promoting Agent: A) Cyclosporinementioning

confidence: 99%

An Extensive Review of Literature: Considering Bone Reaction To Different Agents In Orthodontically Induced Root And Alveolar Resorption

2017

IJDA

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ABSTRACT:Orthodontically induced root resorption is a common problem in day to day practice. If such root resorption could be prevented, it would be an important contribution toward reducing risk factors in orthodontic treatment. The aim of the review is to focus on different agents which can be therapeutically useful in orthodontic tooth movement. The article reviews various agents inhibiting as well as promoting root and alveolar bone resorption to orthodontic tooth movement based on advanced PUBMED, Cochrane database, Wiley online search of the English language literature from the year 1951 to present in order to help us select the most suitable among them fulfilling the desired criteria of being safe, having less adverse effects, minimal contraindications, rare cross reactions, economically viable, having a scope to be used for successful prognosis and possibly not requiring any special considerations to interpret the results.Forty-nine articles were included in the review, but their interpretation was hindered by the variability in experimental design, magnitude of force applied during tooth movement, and medication regimens. Corticosteroid hormones, parathyroid hormone, and thyroxin have all been shown to increase tooth movement. Bisphosphonates had a strong inhibitory effect.By this review, we conclude that low laser therapy and RGD peptide emerges as the clear winner and can result in better prognosis in orthodontic treatment. These techniques are new and cannot replace the conventional agents as a whole.

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“…Corticosteroids are commonly used to treat many different diseases because of their anti-inflammatory effect. (75) A study was done to investigate the effect of different courses of glucocorticosteroid treatment on orthodontically induced root resorption. Rats were divided into three groups: control, acute and chronic.…”

Section: Glucocorticosteroidsmentioning

confidence: 99%

An extensive review of literature: considering bone reaction to different agents in orthodontically induced root and alveolar resorption

2017

IJODR

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Objective: Orthodontically induced root resorption is a common problem in day to day practice. If such root resorption could be prevented, it would be an important contribution toward reducing risk factors in orthodontic treatment. The aim of the review is to focus on different agents which can be therapeutically useful in orthodontic tooth movement. Methods and Materials: The article reviews various agents inhibiting as well as promoting root and alveolar bone resorption to orthodontic tooth movement based on advanced PubMed Central (PMC), Cochrane database, Wiley online search of the English language literature from the year 1951 to present in order to help us select the most suitable among them fulfilling the desired criteria of being safe, having less adverse effects, minimal contraindications, rare cross reactions, economically viable, having a scope to be used for successful prognosis and possibly not requiring any special considerations to interpret the results. Results: Forty-nine articles were included in the review, but their interpretation was hindered by the variability in experimental design, magnitude of force applied during tooth movement, and medication regimens. Corticosteroid hormones, parathyroid hormone, and thyroxin have all been shown to increase tooth movement. Bisphosphonates had a strong inhibitory effect. Conclusion: By this review, we conclude that low laser therapy and arginylglycylaspartic acid (RGD) peptide emerges as the clear winner and can result in better prognosis in orthodontic treatment. These techniques are new and cannot replace the conventional agents as a whole.

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Effect of cyclosporine‐A on orthodontic tooth movement in rats

Abstract: We suggest that CsA enhanced the rate of orthodontic tooth movement. The osteopenia and the increased osteoclastic activity could be the underlying factors.

Cited by 5 publications

References 48 publications

Sodium-glucose cotransporter 2 inhibition prevents renal fibrosis in cyclosporine nephropathy

Sodium-glucose cotransporter 2 inhibition prevents renal fibrosis in cyclosporine nephropathy

An Extensive Review of Literature: Considering Bone Reaction To Different Agents In Orthodontically Induced Root And Alveolar Resorption

An extensive review of literature: considering bone reaction to different agents in orthodontically induced root and alveolar resorption

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