Healing acceleration of oral mucositis induced by 5‐fluorouracil with <i>Pistacia atlantica</i> (bene) essential oil in hamsters

Tanideh, Nader; Davarmanesh, Mehdy; Andisheh-Tadbir, Azadeh; Ranjbar, Zahra; Mehriar, Peiman; Koohi-Hosseinabadi, Omid

doi:10.1111/jop.12540

Cited by 12 publications

(5 citation statements)

References 24 publications

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“…The clinical inflammatory evaluation was conducted in a single‐blind manner and graded using a score. The scoring criteria were as follows: 0: normal mucosa without hemorrhage, ulceration, or abscess; 1: moderate erythema or hyperemia with no evidence of hemorrhage, ulceration, or abscess; 2: severe erythema and hyperemia; the presence of hemorrhage, small ulcerations, or scar tissue without abscess; 3: severe erythema and hyperemia with the presence of hemorrhage, extensive ulceration, and abscess (Lima et al, 2005; Tanideh et al, 2017).…”

Section: Methodsmentioning

confidence: 99%

Recombination humanized type III collagen promotes oral ulcer healing

Shuai

Kang

et al. 2023

Oral Diseases

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ObjectiveRecombinant humanized type III collagen (rhCol III) is a highly adhesive biomaterial composed of 16 adhesion‐related tandem repeats refined from human type III collagen. Here, we aimed to investigate the effect of rhCol III on oral ulcers and reveal the underlying mechanism.MethodsAcid‐induced oral ulcers were induced on the murine tongue, and rhCol III or saline drops were administered. The effect of rhCol III on oral ulcers was assessed using gross and histological analyses. The effects on the proliferation, migration, and adhesion of human oral keratinocytes were investigated in vitro. The underlying mechanism was explored using RNA sequencing.ResultsAdministration of rhCol III accelerated the lesion closure of oral ulcers, reduced the release of inflammatory factors, and alleviated pain. rhCol III promoted the proliferation, migration, and adhesion of human oral keratinocytes in vitro. Mechanistically, the enrichment of genes associated with the Notch signaling pathway was upregulated after rhCol III treatment.ConclusionrhCol III promoted the healing of oral ulcers, showing promising therapeutic potential in oral clinics.

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Section: Methodsmentioning

confidence: 99%

Recombination humanized type III collagen promotes oral ulcer healing

Shuai

Kang

et al. 2023

Oral Diseases

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“…The results suggest that excision of the wound leads to oxidative stress and topical administration of P. atlantica gels causes remarkable changes in the antioxidant parameters during wound closure via pro-oxidative and antioxidant activities which can reduce oxidative stress. In another study, the healing effect of an essential oil extracted from P. atlantica hull was evaluated by Tanideh et al (2017) for the treatment of oral mucositis in golden hamsters.…”

Section: Wound Healing Activitymentioning

confidence: 99%

Four Pistacia atlantica subspecies (atlantica, cabulica, kurdica and mutica): A review of their botany, ethnobotany, phytochemistry and pharmacology

Ahmed

Yousfi

Viaene

et al. 2021

Journal of Ethnopharmacology

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“…Modern medicine recognizes herbalism derived from natural sources as an alternative medicine, phytotherapy in many diseases and a preventive method against complications that result in chemotherapy-induced OM. Calendula officinalis (C. officinalis) (7), Hypericum perforatum (8), Pistacia atlantica and Zizyphus jujuba have been used to accelerate the healing of OM (9,10).…”

Section: Introductionmentioning

confidence: 99%

Effect of Topical 2% Eucalyptus Extract on 5-FU-Induced Oral Mucositis in Male Golden Hamsters

et al. 2020

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Oral mucositis is a common inflammatory complication among patients with cancer. This study evaluated the histopathological, stereological, and antioxidant markers of 2% eucalyptus extract in induced oral mucositis in male golden hamsters. In this animal study, oral mucositis was induced in 30 male golden hamsters by 5-FU (60 mg/kg) on days 0, 5, and 10 of the study. The cheek pouch was scratched with a sterile needle once daily on days 3 and 4. On days 14-17, 2% eucalyptus hydroalcoholic extract gel and Calendula officinalis extract gel groups were treated and then compared with a non-treated control group. The histopathological and stereological scores and the pouch content of malondialdehyde, as well as the activities of glutathione and myeloperoxidase in the pouch tissue, were evaluated. Histopathologic scores of oral mucositis were lower in the eucalyptus gel group than those of the calendula and control groups (p<0.05). Also, a lower malondialdehyde level and higher myeloperoxidase and glutathione activities were detected in the eucalyptus group in comparison to the calendula and control groups (p<0.001). The thickness of the mucosa and submucosa increased in the eucalyptus group. The numerical density of the fibroblast and the volume density of the collagen significantly increased in the eucalyptus group. In conclusion, the use of eucalyptus hydroalcoholic extract may be associated with reduced intensity of oral mucositis, diminished concentration of malondialdehyde, increased activity of myeloperoxidase and glutathione, increased volume of mucosa and submucosa, increased fibroblast and collagen in the induced oral mucositis in golden hamsters undergoing 5-FU consumption.

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Healing acceleration of oral mucositis induced by 5‐fluorouracil with Pistacia atlantica (bene) essential oil in hamsters

Abstract: The healing effect of the bene oil could mainly be local and attributed to its antioxidants and fatty acid contents present in non-saponified and saponified fractions, respectively.

Cited by 12 publications

References 24 publications

Recombination humanized type III collagen promotes oral ulcer healing

Recombination humanized type III collagen promotes oral ulcer healing

Four Pistacia atlantica subspecies (atlantica, cabulica, kurdica and mutica): A review of their botany, ethnobotany, phytochemistry and pharmacology

Effect of Topical 2% Eucalyptus Extract on 5-FU-Induced Oral Mucositis in Male Golden Hamsters

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