Healable Antifouling Films Composed of Partially Hydrolyzed Poly(2-ethyl-2-oxazoline) and Poly(acrylic acid)

Li, Yixuan; Pan, Tiezheng; Ma, Benhua; Liu, Junqiu; Sun, Junqi

doi:10.1021/acsami.7b02872

Cited by 51 publications

(42 citation statements)

References 61 publications

(106 reference statements)

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“…Sequential deposition of thiol-containing PEOX/poly(methacrylic acid) multilayers onto silica particle templates and crosslinking yielded stable capsules after removing the silica templates [50]. Sun et al demonstrated that the film prepared with partially hydrolyzed PEOX and PAA shows healable and anti-fouling properties [51].…”

Section: Introductionmentioning

confidence: 99%

Hydrogen-Bonded Polymer Complex Thin Film of Poly(2-oxazoline) and Poly(acrylic acid)

Su¹,

Sun²,

Zhang³

et al. 2017

Polymers

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Abstract:The hydrogen-bonded polymer complex thin film of poly(2-ethyl-2-oxazoline) (PEOX) and poly(acrylic acid) (PAA) was fabricated with layer-by-layer (LbL) assembly. The film shows exponential growth at early stage and transfers to linear growth after 10 assembling cycles, and the stable thickness increment per assembling cycle in the linear region could be higher than 100 nm. The film growth should be related with polymer chain diffusion during LbL assembly. The effects of assembling time, rinsing time, temperature, pH value, concentration and molecular weight on the thin film growth were investigated. Increasing the assembly time, the temperature and the concentration is favorable to produce the thick film. Prolonging rinsing time is good for preparing smooth film. The film can be constructed below pH 4.5 while the prepared film will not completely dissolve until pH value elevates to 7.0. Molecular weight has a subtle effect on the PEOX/PAA film growth. The PEOX-PAA pair that has a big molecular weight contrast shows fast film growth in the linear region.

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Section: Introductionmentioning

confidence: 99%

Hydrogen-Bonded Polymer Complex Thin Film of Poly(2-oxazoline) and Poly(acrylic acid)

Su¹,

Sun²,

Zhang³

et al. 2017

Polymers

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“…All these merits make polymeric complexes suitable for convenient and cost‐effective fabrication of self‐healing/healable polymeric materials with enhanced mechanical strength. Up to now, most self‐healing/healable polymeric materials based on polymeric complexes are fabricated by layer‐by‐layer assembly method involving alternate deposition of polymers with complementary noncovalent interactions at interface of solid substrates and polymer solutions . Among the few examples of self‐healing/healable polymeric composite materials fabricated with polymeric complexes, they have low mechanical strength with tensile strength of several megapascals and exhibit decreased stability after a long‐term exposure to water .…”

Section: Summary Of Mechanical Properties Of the Paa–pvpon Compositesmentioning

confidence: 99%

Healable and Mechanically Super‐Strong Polymeric Composites Derived from Hydrogen‐Bonded Polymeric Complexes

et al. 2019

Self Cite

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of damaging−healing process in a given region without concern about depletion of healing agents. [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16] However, the fabrication of intrinsic self-healing/healable polymer materials with strong mechanical strength remains a great challenge because the diffusion of polymer chains, which is the prerequisite for the healing function, is largely hindered. [3,5,16] By using dense thiourea hydrogen bonds as reversible cross-linkers, Aida and coworkers have fabricated self-healing poly(ether-thioureas) with a tensile stress of 45 ± 8 MPa and an elastic modulus of 1.4 GPa. [3] The poly(ether-thioureas) is by far the mechanically strongest polymers capable of healing physical damage at room temperature. Unlike conventional polymers based on covalent bonds, supramolecular polymers are constructed from monomeric units that are connected through noncovalent interactions such as hydrogen bonding, host-guest interactions, metal coordination, π-π stacking interactions, and so forth. [10,[17][18][19][20][21][22][23] The dynamic nature of noncovalent interactions endows supramolecular polymers with various unique properties such as stimulus response, [23,24] self-healing, [10,22,25,26] and recycling abilities. [27,28] On account of dynamic and weak nature of noncovalent interactions among monomeric units, the molecular weight of supramolecular polymers is usually low and the entanglement of short polymer chains is severely limited. [17,20] Therefore, most supramolecular polymers are soft and are unsuitable for the fabrication of self-healing/healable polymer materials with high mechanical strength.Polymeric complexes can be produced by mixing polymers with complementary noncovalent interactions in bulk solution or sequentially at interface of solid substrates and polymer solutions. [5,16,[29][30][31][32][33][34][35][36][37] Given that various polymers bearing complementary interactions can be employed to prepare polymeric complexes, polymeric composite materials based on polymeric complexes can possess various compositions, controllable cross-linking density, and well-tailored mechanical properties. [31,33,35,[37][38][39] During the formation of polymeric complexes, polymers with self-assembly ability can generate welldesigned micro-/nanosized structures, which provide a facile way to further tailor the mechanical properties of the resultant materials. [29] Similar to supramolecular polymers, the reversible noncovalent interaction among polymer chains can also It is challenging to fabricate mechanically super-strong polymer composites with excellent healing capacity because of the significantly limited mobility of polymer chains. The fabrication of mechanically super-strong polymer composites with excellent healing capacity by complexing polyacrylic acid (PAA) with polyvinylpyrrolidone (PVPON) in aqueous solution followed by molding into desired shapes is presented. The coiled PVPON can complex with PAA in water via hydrogen-bonding interactions to produce transparent PAA-PVPON compos...

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“…Several microns-thick PEOXA-EI/PAA multilayers, obtained after thermal crosslinking of pristine LbL assemblies, efficiently resisted contamination by Escherichia coli (E. coli) and Bacillus subtilis (B. subtilis), and additionally featured healable properties when mechanically damaged. [30] The biopassive and pH-responsive properties of very similar LbL coatings deposited on SiO 2 surfaces were investigated in detail by the group of Siew Tan (Figure 3d). Crosslinked PEOXA-EI/PAA multilayered films presented a tunable swollen thickness as a function of pH, while they significantly suppressed surface contamination by BSA (Figure 3e), fibroblasts, E. coli and Staphylococcus aureus (S. aureus).…”

Section: Surface Functionalization Strategiesmentioning

confidence: 99%

Fabrication of Biopassive Surfaces Using Poly(2‐alkyl‐2‐oxazoline)s: Recent Progresses and Applications

Trachsel

Romio

Ramakrishna

et al. 2020

Adv Materials Inter

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monomer composition enables to obtain hydrophilic and bioinert and/or amphiphilic PAOXA species displaying thermoresponsive properties. [6] Simultaneously, careful choice of initiator and/or terminator agents gives access to end-functional or heterobifunctional polymers, which can be directly applied for surface modification, or used as building blocks to yield structurally more complex adsorbates targeting specific substrates or generating well-defined polymer architectures at the interface. [7-9] Among the most recent studies focusing on the fabrication of biopassive PAOXA films, most of them involved grafting of pre-synthesized adsorbates by exploiting functional anchors that are specific for the target substrate to passivate. In other works, the growth of a PAOXAbased film was triggered from the substrate itself, through surface-initiated CROP (SI-CROP), while interest has been rising in applying plasma polymerization of 2-oxazolines to generate robustly attached coatings on an array of different supports. Through these strategies, and with the general objective of suppressing nonspecific interaction with biological entities, a broad range of biomaterials, ranging from inorganic supports, plastics and nanomaterials of diverse composition have been successfully functionalized with PAOXAs. While during the first decade of 2000s efforts were spent in dissecting the fundamental properties of PAOXAs assemblies on surfaces, [3,10,11] during the past five years their application in different coating formulations for biomaterials has been progressively expanding, and at least some of them are probably mature for a direct involvement of industry. In this progress report, we critically review the most recent studies focusing on the fabrication of PAOXA coatings, especially concentrating on the generation of bioinert surfaces, which probably represents their most appealing and technologically relevant application. 2. Composition of Bioinert PAOXA-Based Surfaces Among the different PAOXA species that were applied on surfaces to generate coatings, hydrophilic poly(2-methyl-2-oxazoline) (PMOXA) and poly(2-ethyl-2-oxazoline) (PEOXA) showed the most pronounced inertness towards nonspecific interactions with serum proteins, cells and bacteria. A recent study by Morgese et al. identified the superior biopassivity of linear Poly(2-alkyl-2-oxazoline)s (PAOXAs) are emerging among the most promising nonionic alternatives to poly(ethylene glycol)s (PEGs), specifically in the modification and functionalization of biomaterials. Due to their chemical tailorability and robustness, coupled to their relatively easy synthesis, PAOXAs are increasingly applied as adsorbates to generate bioinert surfaces that prevent nonspecific contamination by proteins, cells and bacteria. Passivation of medical devices, sensors and cell-sensitive platforms with PAOXAs enables a nearly quantitative suppression of nonspecific biological contamination, while biopassivity is maintained over longer incubation times than those recorded for more degradable PEG-b...

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Healable Antifouling Films Composed of Partially Hydrolyzed Poly(2-ethyl-2-oxazoline) and Poly(acrylic acid)

Cited by 51 publications

References 61 publications

Hydrogen-Bonded Polymer Complex Thin Film of Poly(2-oxazoline) and Poly(acrylic acid)

Hydrogen-Bonded Polymer Complex Thin Film of Poly(2-oxazoline) and Poly(acrylic acid)

Healable and Mechanically Super‐Strong Polymeric Composites Derived from Hydrogen‐Bonded Polymeric Complexes

Fabrication of Biopassive Surfaces Using Poly(2‐alkyl‐2‐oxazoline)s: Recent Progresses and Applications

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